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学科主题: 基础医学
题名:
The role of NR2B containing NMDA receptor in place preference conditioned with morphine and natural reinforcers in rats
作者: Ma, Yao-Ying; Guo, Chang-Yong; Yu, Peng; Lee, David Yue-Wei; Han, Ji-Sheng; Cui, Cai-Lian
关键词: conditioned place preference ; morphine ; natural reinforcers ; NMDA receptor ; rats
刊名: EXPERIMENTAL NEUROLOGY
发表日期: 2006-08-01
DOI: 10.1016/j.expneurol.2006.02.117
卷: 200, 期:2, 页:343-355
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: PRECIPITATED OPIOID WITHDRAWAL ; D-ASPARTATE RECEPTORS ; PREFRONTAL CORTEX ; NUCLEUS-ACCUMBENS ; DRUG-ABUSE ; BASOLATERAL AMYGDALA ; SENSATION SEEKING ; COCAINE-SEEKING ; ADDICTIVE DRUGS ; INDUCED REWARD
英文摘要:

It has been reported that N-methyl-D-aspartate (NMDA) receptor is implicated in drug addiction and antagonists of the NMDA receptor complex can inhibit the development and expression of conditioned place preference (CPP) induced by several addictive drugs, implying that this class of compounds might be considered as candidate for the treatment of substance abuse. To explore this possibility, it is important to evaluate whether the inhibitory effect of NMDA receptor antagonists would be confined to behaviors produced by drugs of abuse only, but not by natural reinforcers. According to the quantitative changes of NMDA receptor subunits, including NR1, NR2A, and NR2B, induced by diverse types of reinforcers, we chose NR2B subunit as the target of research. Experimental results showed that (1) an augmented expression of NR2B subunit was revealed by Western blotting in the nucleus accumbens (NAc) and the hippocampus in rats with CPP induced by morphine, but not by natural rewards such as food, novel environment and social interaction. (2) Ifenprodil, an antagonist highly selective for NR2B subunit of the NMDA receptor, produced a dose-dependent reduction in CPP induced by morphine and novel environment, but not that by food consumption and social interaction. Taking together, these findings suggested that NR2B containing NMDA receptor may be more involved with morphine reward rather than natural rewards, and that antagonism of NR2B may have a potential for the treatment of morphine abuse. (c) 2006 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000239647100008
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68077
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Hlth Sci Ctr, Key Lab Neurosci,Minist Educ, Beijing 100083, Peoples R China
2.Peking Univ, Dept Neurobiol, Hlth Sci Ctr, Key Lab Neurosci,Minist Educ, Beijing 100083, Peoples R China
3.Minist Publ Hlth, Beijing 100083, Peoples R China
4.Harvard Univ, Sch Med, McLean Hosp, Bioorgan & Nat Prod Lab, Belmont, MA 02478 USA

Recommended Citation:
Ma, Yao-Ying,Guo, Chang-Yong,Yu, Peng,et al. The role of NR2B containing NMDA receptor in place preference conditioned with morphine and natural reinforcers in rats[J]. EXPERIMENTAL NEUROLOGY,2006,200(2):343-355.
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