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学科主题: 基础医学
题名:
Phylogenetic Analysis of Kindlins Suggests Subfunctionalization of an Ancestral Unduplicated Kindlin into Three Paralogs in Vertebrates
作者: Khan, Ammad Aslam1; Janke, Axel2; Shimokawa, Takashi1; Zhang, Hongquan1,3,4,5
关键词: kindlins ; cell adhesion molecules ; phylogenetics ; natural selection ; molecular evolution ; integrin interacting proteins
刊名: EVOLUTIONARY BIOINFORMATICS
发表日期: 2011
DOI: 10.4137/EBO.S6179
卷: 7, 页:7-19
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Evolutionary Biology ; Mathematical & Computational Biology
研究领域[WOS]: Evolutionary Biology ; Mathematical & Computational Biology
关键词[WOS]: CELL-MATRIX ADHESION ; INTEGRIN ACTIVATION ; GENE ; PROTEIN ; DUPLICATIONS ; LOCALIZATION ; EVOLUTION ; COMPONENT ; UNC-112
英文摘要:

Kindlin proteins represent a newly discovered family of evolutionarily conserved FERM domain-containing proteins. This family includes three highly conserved proteins: Kindlin-1, Kindlin-2 and Kindlin-3. All three Kindlin proteins are associated with focal adhesions and are involved in integrin activation. The FERM domain of each Kindlin is bipartite and plays a key role in integrin activation. We herein explore for the first time the evolutionary history of these proteins. The phylogeny of the Kindlins suggests a single ancestral Kindlin protein present in even the earliest metazoan ie, hydra. This protein then underwent duplication events in insects and also experienced genome duplication in vertebrates, leading to the Kindlin family. A comparative study of the Kindlin paralogs showed that Kindlin-2 is the slowest evolving protein among the three family members. The analysis of synonymous and non-synonymous substitutions in orthologous Kindlin sequences in different species showed that all three Kindlins have been evolving under the influence of purifying selection. The expression pattern of Kindlins along with phylogenetic studies supports the subfunctionalization model of gene duplication.

语种: 英语
所属项目编号: 30830048 ; 2010CB912203 ; 2010CB529402
项目资助者: Swedish Cancer Foundation ; Swedish Society of Medicine ; Swedish Research Council ; Karolinska Institute ; Nature Science Foundation of China ; Ministry of Science and Technology of China ; Peking University
WOS记录号: WOS:000288867200002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68079
Appears in Collections:基础医学院_北京大学系统生物医学研究所_期刊论文

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作者单位: 1.LOEWE Biodivers & Climate Res Ctr BiK F, D-60325 Frankfurt, Germany
2.Peking Univ, Inst Syst Biomed, Beijing 100191, Peoples R China
3.Karolinska Inst, Ctr Biosci, Dept Biosci & Nutr, S-14183 Huddinge, Sweden
4.Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100191, Peoples R China
5.Peking Univ, Lab Mol Cell Biol & Tumor Biol, Sch Basic Med Sci, Beijing 100191, Peoples R China

Recommended Citation:
Khan, Ammad Aslam,Janke, Axel,Shimokawa, Takashi,et al. Phylogenetic Analysis of Kindlins Suggests Subfunctionalization of an Ancestral Unduplicated Kindlin into Three Paralogs in Vertebrates[J]. EVOLUTIONARY BIOINFORMATICS,2011,7:7-19.
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