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学科主题: 基础医学
题名:
Recombinant human PDCD5 protein enhances chemosensitivities of hematologic malignancies
作者: Wang YanFang2; Shi Lin2; Song QuanSheng1,3; Zhang YingMei1,3; Lou YaXin4; Zheng Yi1,3; Ma DaLong1,3; Wang Ying1,3; Ke XiaoYan2
关键词: hematologic malignancies ; PDCD5 ; apoptosis ; chemotherapy ; chemosensitivity
刊名: CHINESE SCIENCE BULLETIN
发表日期: 2009-11-01
DOI: 10.1007/s11434-009-0635-z
卷: 54, 期:21, 页:3981-3989
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: GENE-EXPRESSION PROFILES ; DRUG-INDUCED APOPTOSIS ; TUMOR-CELLS ; IN-VIVO ; CROSS-RESISTANCE ; CANCER ; LEUKEMIA ; DEATH ; OVEREXPRESSION ; GROWTH
英文摘要:

PDCD5 is a novel apoptosis-related gene. Overexpression of PDCD5 facilitates apoptosis in various tumor cells. Here, we investigated the roles of recombinant human PDCD5 (rhPDCD5) protein in chemosensitivities of hematologic malignancies. The rhPDCD5 increased the in vitro cytotoxicity of daunorubicin (DNR), adriamycin (ADM) and As2O3 in three hematologic tumor cell lines. In vivo studies showed that DNR combined with rhPDCD5 significantly suppressed tumor growth of U937 xenograft nude mice compared with DNR alone. In conclusion, rhPDCD5 combined with the chemotherapeutic drug has greater efficacy than chemotherapy alone, and rhPDCD5 is a very promising chemosensitizer.

语种: 英语
所属项目编号: 2006AA02A305 ; 30671907 ; 5072029 ; 985-2-032-24
项目资助者: National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Special Fund for Promotion of Ministry of Education
WOS记录号: WOS:000271760400019
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68084
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: 1.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
2.Peking Univ, Dept Hematol, Hosp 3, Beijing 100191, Peoples R China
3.Peking Univ, Dept Med Immunol, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100191, Peoples R China
4.Peking Univ, Med & Hlth Anal Ctr, Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Wang YanFang,Shi Lin,Song QuanSheng,et al. Recombinant human PDCD5 protein enhances chemosensitivities of hematologic malignancies[J]. CHINESE SCIENCE BULLETIN,2009,54(21):3981-3989.
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