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学科主题临床医学
Prevalence of Candida albicans-closely related yeasts, Candida africana and Candida dubliniensis, in vulvovaginal candidiasis
Shan, Yingying1; Fan, Shangrong1,2; Liu, Xiaoping3; Li, Jianling1
关键词vulvovaginal candidiasis Candida africana Candida dubliniensis
刊名MEDICAL MYCOLOGY
2014-08-01
DOI10.1093/mmy/myu003
52期:6页:636-640
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Mycology ; Veterinary Sciences
资助者Shenzhen Science and Technology ; Shenzhen Science and Technology
研究领域[WOS]Mycology ; Veterinary Sciences
关键词[WOS]MOLECULAR CHARACTERIZATION ; GENE ; HWP1
英文摘要

Isolates of Candida africana and C. dubliniensis were recovered from patients with vulvovaginal candidiasis (VVC). The isolates were initially identified as C. albicans through use of the API Candida System. We retrospectively reexamined 1014 vaginal isolates presumptively determined to be C. albicans at the Department of Obstetrics and Gynecology of Peking University Shenzhen Hospital from 1 January 2003 through 31 December 2012. Our objective was to determine, via detection of the HWP1 gene, if any of the isolates were C. africana or C. dubliniensis. One and a half percent of these isolates (15/1014) were found to be C. africana, whereas C. dubliniensis was not detected. The 15 C. africana isolates were susceptible to nystatin, fluconazole, itraconazole, miconazole, and clotrimazole. Candida africana could not be recovered from clinical vaginal specimens from the 15 patients at follow-up on days 7-14 and days 30-35 when treated with different antifungal agents. We conclude that C. africana, but not C. dubliniensis, was present in the vaginal samples of patients with VVC. The C. africana isolates were susceptible to the tested antifungal agents. VVC caused by C. africana appears to respond well to current therapies.

语种英语
所属项目编号20120320020 ; 201102020
资助者Shenzhen Science and Technology ; Shenzhen Science and Technology
WOS记录号WOS:000339915400009
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68091
Collection北京大学深圳医院
作者单位1.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen 518036, Peoples R China
2.Shenzhen Key Lab Gynecol Diagnost Technol Res, Shenzhen 518036, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Lab Sci, Shenzhen 518036, Peoples R China
Recommended Citation
GB/T 7714
Shan, Yingying,Fan, Shangrong,Liu, Xiaoping,et al. Prevalence of Candida albicans-closely related yeasts, Candida africana and Candida dubliniensis, in vulvovaginal candidiasis[J]. MEDICAL MYCOLOGY,2014,52(6):636-640.
APA Shan, Yingying,Fan, Shangrong,Liu, Xiaoping,&Li, Jianling.(2014).Prevalence of Candida albicans-closely related yeasts, Candida africana and Candida dubliniensis, in vulvovaginal candidiasis.MEDICAL MYCOLOGY,52(6),636-640.
MLA Shan, Yingying,et al."Prevalence of Candida albicans-closely related yeasts, Candida africana and Candida dubliniensis, in vulvovaginal candidiasis".MEDICAL MYCOLOGY 52.6(2014):636-640.
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