IR@PKUHSC  > 北京大学第三临床医学院  > 眼科
学科主题临床医学
Autologous Transplantation of Simple Retinal Pigment Epithelium Sheet for Massive Submacular Hemorrhage Associated With Pigment Epithelium Detachment
Han, Liang1; Ma, Zhizhong1; Wang, Changguan1; Dou, Hongliang1; Hu, Yuntao1; Feng, Xuefeng1; Xu, Yimin1; Yin, Zhengqin2; Wang, Xin1
关键词age-related macular degeneration massive submacular hemorrhage pigment epithelium detachment polypoidal choroidal vasculopathy simple RPE sheet transplantation sub-RPE hemorrhage
刊名INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
2013-07-01
DOI10.1167/iovs.13-11957
54期:7页:4956-4963
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]POLYPOIDAL CHOROIDAL VASCULOPATHY ; MACULAR DEGENERATION ; PHOTODYNAMIC THERAPY ; VISUAL-ACUITY ; SURGERY ; TRANSLOCATION ; NEOVASCULARIZATION ; RANIBIZUMAB ; VITRECTOMY ; SECONDARY
英文摘要

PURPOSE. To evaluate the long-term outcome of autologous simple RPE sheet transplantation in patients with simultaneous massive submacular hemorrhage and pigment epithelium detachment (PED).

METHODS. Fourteen patients with 10 occult AMD eyes and 4 PCV eyes underwent a surgical procedure including a 180 degrees peripheral temporal retinotomy, choroidal neovascular membrane (CNVM) excision, and transplantation of an autologous simple RPE sheet developed from the PED region outside the CNVM lesion. Best-corrected visual acuity, multifocal ERG, and microperimetry were recorded to evaluate macular function. Optical coherence tomography, fundus fluorescein angiography, and an RPE autofluorescence test were performed to observe the status of the transplanted simple RPE sheet.

RESULTS. Mean follow-up duration was 24 +/- 6 months. Mean ETDRS score increased from 14.0 +/- 23.4 preoperatively to 31.+/- 6 23.8 at 18 months postoperatively (P < 0.05). Of 14 eyes, 5 (36%) presented with central fixation postoperatively, whereas only 3 (21%) eyes presented with central fixation preoperatively. Ten grafts (71%) showed normal RPE color. Postoperative complications included one (7%) retinal detachment due to proliferative vitreoretinopathy and one (7%) delayed recurrent submacular hemorrhage.

CONCLUSIONS. Transplantation of an autologous simple RPE sheet for eyes with massive submacular hemorrhage associated with PED was achieved with a simplified surgical procedure, resulting in increased postoperative visual acuity.

语种英语
WOS记录号WOS:000322637000068
项目编号2011CB510200
资助机构national basic research program of China (973) ; Peking University Third Hospital
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68093
专题北京大学第三临床医学院_眼科
北京大学基础医学院
作者单位1.Peking Univ, Hosp 3, Dept Ophthalmol, Key Lab Vis Loss & Restorat,Minist Educ, Beijing 100191, Peoples R China
2.Third Mil Med Univ, Southwest Eye Hosp, Chongqing, Peoples R China
推荐引用方式
GB/T 7714
Han, Liang,Ma, Zhizhong,Wang, Changguan,et al. Autologous Transplantation of Simple Retinal Pigment Epithelium Sheet for Massive Submacular Hemorrhage Associated With Pigment Epithelium Detachment[J]. INVESTIGATIVE OPHTHALMOLOGY &amp; VISUAL SCIENCE,2013,54(7):4956-4963.
APA Han, Liang.,Ma, Zhizhong.,Wang, Changguan.,Dou, Hongliang.,Hu, Yuntao.,...&Wang, Xin.(2013).Autologous Transplantation of Simple Retinal Pigment Epithelium Sheet for Massive Submacular Hemorrhage Associated With Pigment Epithelium Detachment.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,54(7),4956-4963.
MLA Han, Liang,et al."Autologous Transplantation of Simple Retinal Pigment Epithelium Sheet for Massive Submacular Hemorrhage Associated With Pigment Epithelium Detachment".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54.7(2013):4956-4963.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Autologous Transplan(696KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Han, Liang]的文章
[Ma, Zhizhong]的文章
[Wang, Changguan]的文章
百度学术
百度学术中相似的文章
[Han, Liang]的文章
[Ma, Zhizhong]的文章
[Wang, Changguan]的文章
必应学术
必应学术中相似的文章
[Han, Liang]的文章
[Ma, Zhizhong]的文章
[Wang, Changguan]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Autologous Transplantation of Simple Retinal Pigment Epithelium Sheet for Massive Submacular Hemorrhage Associated With Pigment Epithelium Detachment.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。