IR@PKUHSC  > 北京大学第三临床医学院  > 眼科
学科主题临床医学
Autologous Transplantation of Simple Retinal Pigment Epithelium Sheet for Massive Submacular Hemorrhage Associated With Pigment Epithelium Detachment
Han, Liang1; Ma, Zhizhong1; Wang, Changguan1; Dou, Hongliang1; Hu, Yuntao1; Feng, Xuefeng1; Xu, Yimin1; Yin, Zhengqin2; Wang, Xin1
关键词age-related macular degeneration massive submacular hemorrhage pigment epithelium detachment polypoidal choroidal vasculopathy simple RPE sheet transplantation sub-RPE hemorrhage
刊名INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
2013-07-01
DOI10.1167/iovs.13-11957
54期:7页:4956-4963
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
资助者national basic research program of China (973) ; Peking University Third Hospital ; national basic research program of China (973) ; Peking University Third Hospital
研究领域[WOS]Ophthalmology
关键词[WOS]POLYPOIDAL CHOROIDAL VASCULOPATHY ; MACULAR DEGENERATION ; PHOTODYNAMIC THERAPY ; VISUAL-ACUITY ; SURGERY ; TRANSLOCATION ; NEOVASCULARIZATION ; RANIBIZUMAB ; VITRECTOMY ; SECONDARY
英文摘要

PURPOSE. To evaluate the long-term outcome of autologous simple RPE sheet transplantation in patients with simultaneous massive submacular hemorrhage and pigment epithelium detachment (PED).

METHODS. Fourteen patients with 10 occult AMD eyes and 4 PCV eyes underwent a surgical procedure including a 180 degrees peripheral temporal retinotomy, choroidal neovascular membrane (CNVM) excision, and transplantation of an autologous simple RPE sheet developed from the PED region outside the CNVM lesion. Best-corrected visual acuity, multifocal ERG, and microperimetry were recorded to evaluate macular function. Optical coherence tomography, fundus fluorescein angiography, and an RPE autofluorescence test were performed to observe the status of the transplanted simple RPE sheet.

RESULTS. Mean follow-up duration was 24 +/- 6 months. Mean ETDRS score increased from 14.0 +/- 23.4 preoperatively to 31.+/- 6 23.8 at 18 months postoperatively (P < 0.05). Of 14 eyes, 5 (36%) presented with central fixation postoperatively, whereas only 3 (21%) eyes presented with central fixation preoperatively. Ten grafts (71%) showed normal RPE color. Postoperative complications included one (7%) retinal detachment due to proliferative vitreoretinopathy and one (7%) delayed recurrent submacular hemorrhage.

CONCLUSIONS. Transplantation of an autologous simple RPE sheet for eyes with massive submacular hemorrhage associated with PED was achieved with a simplified surgical procedure, resulting in increased postoperative visual acuity.

语种英语
所属项目编号2011CB510200
资助者national basic research program of China (973) ; Peking University Third Hospital ; national basic research program of China (973) ; Peking University Third Hospital
WOS记录号WOS:000322637000068
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68093
Collection北京大学第三临床医学院_眼科
作者单位1.Peking Univ, Hosp 3, Dept Ophthalmol, Key Lab Vis Loss & Restorat,Minist Educ, Beijing 100191, Peoples R China
2.Third Mil Med Univ, Southwest Eye Hosp, Chongqing, Peoples R China
Recommended Citation
GB/T 7714
Han, Liang,Ma, Zhizhong,Wang, Changguan,et al. Autologous Transplantation of Simple Retinal Pigment Epithelium Sheet for Massive Submacular Hemorrhage Associated With Pigment Epithelium Detachment[J]. INVESTIGATIVE OPHTHALMOLOGY &amp; VISUAL SCIENCE,2013,54(7):4956-4963.
APA Han, Liang.,Ma, Zhizhong.,Wang, Changguan.,Dou, Hongliang.,Hu, Yuntao.,...&Wang, Xin.(2013).Autologous Transplantation of Simple Retinal Pigment Epithelium Sheet for Massive Submacular Hemorrhage Associated With Pigment Epithelium Detachment.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,54(7),4956-4963.
MLA Han, Liang,et al."Autologous Transplantation of Simple Retinal Pigment Epithelium Sheet for Massive Submacular Hemorrhage Associated With Pigment Epithelium Detachment".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 54.7(2013):4956-4963.
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