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学科主题: 基础医学
题名:
Functional maturation of two murine medullary-type CD8SP thymocytes
作者: Tian, T; Qian, XP; Gao, L; Chen, WF
关键词: CD4(-)CD8(+) thymocyte ; phenotype ; function
刊名: CHINESE SCIENCE BULLETIN
发表日期: 2001-05-01
卷: 46, 期:9, 页:746-751
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要:

TCR alpha beta (+)CD4(-)CD8(+) thymocytes are heterogeneity. They may undergo phenotypic and functional maturation within thymic medulla, Medullary-type CD8SP thymocytes were divided into seven subsets based on phenotypic analysis, and their precursor progeny relationship along with the differential pathway was also delineated. To further testify the validity of the maturation pathway, we purified 6C10(-)CD69(+) cells representing the early stage and 6C10(-)Qa-2(+) cells representing the later stage among medullary-type CD8SP thymocytes and compared their functional maturation levels, CD8(+) T cells of spleen were used as the control, It is shown that there is no obvious difference of proliferation ability among these three subsets; however, intracytoplasmic cytokine assay shows that there is a hierarchy of IFN-gamma and TNF alpha secretion among these subsets, strikingly comparable to their phenotypic status among medullary type CD8SP thymocytes. The bioassays of IL-2 and IFN-gamma in culture supernatant give the similar results.

语种: 英语
WOS记录号: WOS:000169054600012
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68094
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: Beijing Med Univ, Dept Immunol, Beijing 100083, Peoples R China

Recommended Citation:
Tian, T,Qian, XP,Gao, L,et al. Functional maturation of two murine medullary-type CD8SP thymocytes[J]. CHINESE SCIENCE BULLETIN,2001,46(9):746-751.
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