IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Functional maturation of two murine medullary-type CD8SP thymocytes
Tian, T; Qian, XP; Gao, L; Chen, WF
关键词CD4(-)CD8(+) thymocyte phenotype function
刊名CHINESE SCIENCE BULLETIN
2001-05-01
46期:9页:746-751
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
英文摘要

TCR alpha beta (+)CD4(-)CD8(+) thymocytes are heterogeneity. They may undergo phenotypic and functional maturation within thymic medulla, Medullary-type CD8SP thymocytes were divided into seven subsets based on phenotypic analysis, and their precursor progeny relationship along with the differential pathway was also delineated. To further testify the validity of the maturation pathway, we purified 6C10(-)CD69(+) cells representing the early stage and 6C10(-)Qa-2(+) cells representing the later stage among medullary-type CD8SP thymocytes and compared their functional maturation levels, CD8(+) T cells of spleen were used as the control, It is shown that there is no obvious difference of proliferation ability among these three subsets; however, intracytoplasmic cytokine assay shows that there is a hierarchy of IFN-gamma and TNF alpha secretion among these subsets, strikingly comparable to their phenotypic status among medullary type CD8SP thymocytes. The bioassays of IL-2 and IFN-gamma in culture supernatant give the similar results.

语种英语
WOS记录号WOS:000169054600012
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68094
Collection北京大学基础医学院_免疫学系
作者单位Beijing Med Univ, Dept Immunol, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Tian, T,Qian, XP,Gao, L,et al. Functional maturation of two murine medullary-type CD8SP thymocytes[J]. CHINESE SCIENCE BULLETIN,2001,46(9):746-751.
APA Tian, T,Qian, XP,Gao, L,&Chen, WF.(2001).Functional maturation of two murine medullary-type CD8SP thymocytes.CHINESE SCIENCE BULLETIN,46(9),746-751.
MLA Tian, T,et al."Functional maturation of two murine medullary-type CD8SP thymocytes".CHINESE SCIENCE BULLETIN 46.9(2001):746-751.
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