IR@PKUHSC  > 北京大学深圳医院
学科主题临床医学
Application of shRNA-containing herpes simplex virus type 1 (HSV-1)-based gene therapy for HSV-2-induced genital herpes
Liu, Zhihong1,2; Xiang, Yang3; Wei, Zhun2,4; Yu, Bo2,4,5,6; Shao, Yong2,4,5,6; Zhang, Jie2,4,5,6; Yang, Hong2,4,5,7; Li, Manmei8; Guan, Ming9; Wan, Jun2,10; Zhang, Wei2,4,5
关键词Herpes simplex virus type 1 (HSV-1) vector Herpes simplex virus type 2 (HSV-2) Genital herpes
刊名JOURNAL OF VIROLOGICAL METHODS
2013-11-01
DOI10.1016/j.jviromet.2013.06.037
193期:2页:353-358
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biotechnology & Applied Microbiology ; Virology
研究领域[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Virology
关键词[WOS]IMMUNOGENICITY ; GLYCOPROTEINS ; PROTECTION ; INFECTION ; IMMUNITY ; NEURONS ; HSV-2 ; MODEL ; MICE
英文摘要

HSV-1-based vectors have been widely used to achieve targeted delivery of genes into the nervous system. In the current study, we aim to use shRNA-containing HSV-1-based gene delivery system for the therapy of HSV-2 infection. Guinea pigs were infected intravaginally with HSV-2 and scored daily for 100 days for the severity of vaginal disease. HSV-2 shRNA-containing HSV-1 was applied intravaginally daily between 8 and 14 days after HSV-2 challenge. Delivery of HSV-2 shRNA-containing HSV-1 had no effect on the onset of disease and acute virus shedding in animals, but resulted in a significant reduction in both the cumulative recurrent lesion days and the number of days with recurrent disease. Around half of the animals in the HSV-2 shRNA group did not develop recurrent disease 100 days post HSV-2 infection. In conclusion, HSV-2 shRNA-containing HSV-1 particles are effective in reducing the recurrence of genital herpes caused by HSV-2. (C) 2013 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000325190400016
项目编号ZYB200907080099A
资助机构Research Grants of Shenzhen Science and Technology Project
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68097
专题北京大学深圳医院
北京大学临床肿瘤学院_护理部
作者单位1.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen 518036, Guangdong, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China
3.Fudan Univ, Huashan Hosp, Dept Gen Surg, Shanghai 200040, Peoples R China
4.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med Dermatol, Shenzhen 518036, Guangdong, Peoples R China
5.Peking Univ, Shenzhen Hosp, Shenzhen Key Discipline Dermatol, Shenzhen 518036, Guangdong, Peoples R China
6.Peking Univ, Shenzhen Hosp, Dept Dermatol, Shenzhen 518036, Guangdong, Peoples R China
7.Peking Univ, Shenzhen Hosp, Dept Clin Lab, Shenzhen 518036, Guangdong, Peoples R China
8.Ji Nan Univ, Coll Pharm, JNU HKUST Joint Lab, Jinan, Guangdong, Peoples R China
9.Fudan Univ, Huashan Hosp, Cent Lab, Dept Lab Med, Shanghai 200040, Peoples R China
10.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Liu, Zhihong,Xiang, Yang,Wei, Zhun,et al. Application of shRNA-containing herpes simplex virus type 1 (HSV-1)-based gene therapy for HSV-2-induced genital herpes[J]. JOURNAL OF VIROLOGICAL METHODS,2013,193(2):353-358.
APA Liu, Zhihong.,Xiang, Yang.,Wei, Zhun.,Yu, Bo.,Shao, Yong.,...&Zhang, Wei.(2013).Application of shRNA-containing herpes simplex virus type 1 (HSV-1)-based gene therapy for HSV-2-induced genital herpes.JOURNAL OF VIROLOGICAL METHODS,193(2),353-358.
MLA Liu, Zhihong,et al."Application of shRNA-containing herpes simplex virus type 1 (HSV-1)-based gene therapy for HSV-2-induced genital herpes".JOURNAL OF VIROLOGICAL METHODS 193.2(2013):353-358.
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