学科主题临床医学
EBMT risk score can predict the outcome of leukaemia after unmanipulated haploidentical blood and marrow transplantation
Wang, H-t1; Chang, Y-j1; Xu, L-p1; Liu, D-h1; Wang, Y.1; Liu, K-y1; Huang, X-j1,2
刊名BONE MARROW TRANSPLANTATION
2014-07-01
DOI10.1038/bmt.2014.80
49期:7页:927-933
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
资助者Key Program of National Natural Science Foundation of China ; Scientific Research Foundation for Capital Medicine Development ; Chang Jiang Scholars Program ; Beijing Municipal Science and Technology Commission ; Key Program of National Natural Science Foundation of China ; Scientific Research Foundation for Capital Medicine Development ; Chang Jiang Scholars Program ; Beijing Municipal Science and Technology Commission
研究领域[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]STEM-CELL TRANSPLANTATION ; CHRONIC MYELOID-LEUKEMIA ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; DONOR LYMPHOCYTE INFUSION ; HEMATOLOGICAL MALIGNANCIES ; COMORBIDITY INDEX ; DEPLETION ; IMPACT ; VALIDATION
英文摘要

Systematic, standardised pretransplant risk assessment is an important tool for predicting patient outcomes following allogeneic haematopoietic SCT (HSCT). To assess the European Group for Blood and Marrow Transplantation (EBMT) risk score capacities for predicting patient outcomes following unmanipulated haploidentical blood and marrow transplantation (HBMT), we analysed 502 leukaemia patients who received transplants at our centre between 2008 and 2010. The cohort OS and leukaemia-free survival (LFS) were 72.1% and 68.1%, whereas the cumulative non-relapse mortality (NRM) and relapse incidences were 16.5% and 16.1%. According to univariate analysis, the values for OS, LFS and NRM were worse for an EBMT risk score of 6 (40.0, 40.0, 50.0%) than a score of 1 (83.1, 78.3, 8.4%). Hazard ratios steadily increased for each additional score point. Likewise, a higher EBMT risk score was associated with an increased relapse incidence. Importantly, the EBMT risk score prognostic value regarding OS, LFS, NRM and relapse was maintained in the multivariate analysis. Moreover, we also made a haploidentical EBMT (haplo-EBMT) risk score, which used number of HLA disparity instead of donor type, and the haplo-EBMT risk scores can also be used to predict patient outcomes following unmanipulated HBMT.

语种英语
所属项目编号81230013 ; 2011-4022-08 ; Z121107002612035 ; Z111107067311070 ; Z121107002812033
资助者Key Program of National Natural Science Foundation of China ; Scientific Research Foundation for Capital Medicine Development ; Chang Jiang Scholars Program ; Beijing Municipal Science and Technology Commission ; Key Program of National Natural Science Foundation of China ; Scientific Research Foundation for Capital Medicine Development ; Chang Jiang Scholars Program ; Beijing Municipal Science and Technology Commission
WOS记录号WOS:000338878100010
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68101
专题北京大学第二临床医学院_北京大学血液病研究所
作者单位1.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Inst Haematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Wang, H-t,Chang, Y-j,Xu, L-p,et al. EBMT risk score can predict the outcome of leukaemia after unmanipulated haploidentical blood and marrow transplantation[J]. BONE MARROW TRANSPLANTATION,2014,49(7):927-933.
APA Wang, H-t.,Chang, Y-j.,Xu, L-p.,Liu, D-h.,Wang, Y..,...&Huang, X-j.(2014).EBMT risk score can predict the outcome of leukaemia after unmanipulated haploidentical blood and marrow transplantation.BONE MARROW TRANSPLANTATION,49(7),927-933.
MLA Wang, H-t,et al."EBMT risk score can predict the outcome of leukaemia after unmanipulated haploidentical blood and marrow transplantation".BONE MARROW TRANSPLANTATION 49.7(2014):927-933.
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