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学科主题: 口腔医学
题名:
Pharmacokinetics of CNT-based Drug Delivery Systems
作者: Ye, Rui1,2; Wang, Sheng1,2; Wang, Jing3; Luo, Zhiqiang4; Peng, Qiang1; Cai, Xiaoxiao1; Lin, Yunfeng1
关键词: Absorption ; CNT ; distribution ; drug release ; excretion ; intracellular internalization ; metabolism ; tumor targeting
刊名: CURRENT DRUG METABOLISM
发表日期: 2013-10-01
卷: 14, 期:8, 页:910-920
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: WALLED CARBON NANOTUBES ; RECEPTOR-MEDIATED ENDOCYTOSIS ; NEAR-INFRARED FLUORESCENCE ; SINGLE-PARTICLE TRACKING ; IN-VIVO ; CANCER-CELLS ; RAMAN-SPECTROSCOPY ; CONTROLLED-RELEASE ; LIVING CELLS ; MACROMOLECULAR THERAPEUTICS
英文摘要:

Carbon nanotubes (CNT) are allotropes of carbon with a cylindrical nanostructure. They have recently aroused great interests as drug carriers, but their pharmacokinetic profiles which determine their potentials in clinical application are yet to be fully understood. Therefore, this overview attempts to outline the processes of absorption, distribution, metabolism and excretion (ADME) that govern the pharmacokinetics of CNT. In addition, the molecular mechanisms of intracellular internalization and drug release are also discussed.

语种: 英语
所属项目编号: 81071273 ; 31170929 ; 81201211 ; FANEDD 200977 ; 2010JQ0066 ; 20110181120071
项目资助者: National Natural Science Foundation of China ; Foundation for the Author of National Excellent Doctoral Dissertation of China ; Funding for Distinguished Young Scientists in Sichuan ; Ministry of Education of China
WOS记录号: WOS:000326168900012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68104
Appears in Collections:北京大学口腔医学院_口腔修复科_期刊论文

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作者单位: 1.Sichuan Univ, State Key Lab Oral Dis, Chengdu 610041, Peoples R China
2.Sichuan Univ, West China Sch Stomatol, Dept Orthodont, Chengdu 610041, Peoples R China
3.Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Stomatol, Shanghai 200092, Peoples R China
4.Peking Univ, Sch Stomatol, Dept Prosthodont, Beijing 100871, Peoples R China

Recommended Citation:
Ye, Rui,Wang, Sheng,Wang, Jing,et al. Pharmacokinetics of CNT-based Drug Delivery Systems[J]. CURRENT DRUG METABOLISM,2013,14(8):910-920.
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