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学科主题: 口腔医学
题名:
Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine
作者: Sonoyama, Wataru3,4; Liu, Yi1,2; Fang, Dianji1,2; Yamaza, Takayoshi3; Seo, Byoung-Moo5; Zhang, Chunmei1,2; Liu, He6; Gronthos, Stan7; Wang, Cun-Yu8,9; Shi, Songtao1,2; Wang, Songlin3
刊名: PLOS ONE
发表日期: 2006-12-20
DOI: 10.1371/journal.pone.0000079
卷: 1, 期:1
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
英文摘要:

Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance.

语种: 英语
所属项目编号: 30428009 ; D0906007000091
项目资助者: University of Southern California School of Dentistry ; National Natural Science Foundation of China ; Beijing Major Scientific program ; Division of Intramural Research ; National Institute of Dental and Craniofacial Research, National Institutes of Health ; Department of Health and Human Service
WOS记录号: WOS:000207443600079
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68105
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Capital Med Univ, Sch Stomatol, Salivary Gland Dis Ctr, Beijing, Peoples R China
2.Capital Med Univ, Sch Stomatol, Mol Lab Gene Therapy, Beijing, Peoples R China
3.Univ So Calif, Ctr Craniofacial Mol Biol, Sch Dent, Los Angeles, CA 90033 USA
4.Okayama Univ, Dept Oral & Maxillofacial Rehabil, Grad Sch Med Dent & Pharmaceut Sci, Okayama, Japan
5.Seoul Natl Univ, Dept Oral & Maxillofacial Rehabil, Sch Dent, Dent Res Inst, Seoul, South Korea
6.Peking Univ, Sch Stomatol, Beijing 100871, Peoples R China
7.Inst Med & Vet Sci, Div Haematol, Mesenchymal Stem Cell Grp, Adelaide, SA 5000, Australia
8.Univ Michigan, Lab Mol Signaling & Apoptosis, Dept Biol & Mat Sci, Ann Arbor, MI 48109 USA
9.Univ Michigan, Program Mol & Cellular Biol, Ann Arbor, MI 48109 USA

Recommended Citation:
Sonoyama, Wataru,Liu, Yi,Fang, Dianji,et al. Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine[J]. PLOS ONE,2006,1(1).
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