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IR@PKUHSC  > 北京大学第三临床医学院  > 超声诊断科  > 期刊论文
学科主题: 临床医学
题名:
Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging
作者: Zha, Zhengbao2; Deng, Zijian1; Li, Yanyan2; Li, Changhui1; Wang, Jinrui3; Wang, Shumin3; Qu, Enze3; Dai, Zhifei1
刊名: NANOSCALE
发表日期: 2013
DOI: 10.1039/c3nr00627a
卷: 5, 期:10, 页:4462-4467
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]: Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: SENTINEL LYMPH-NODE ; IN-VIVO ; CARBON NANOTUBES ; GOLD NANOCAGES ; TOMOGRAPHY ; PARTICLES ; THERAPY ; CANCER ; BRAIN ; LIGHT
英文摘要:

Photoacoustic tomography (PAT) has emerged as a hybrid, nonionizing imaging modality because of its satisfactory spatial resolution and high soft tissue contrast. Here, we demonstrate the application of a novel organic PAT contrast agent based on polypyrrole nanoparticles (PPy NPs). Monodisperse PPy NPs are similar to 46 nm in diameter with strong absorption in the near-infrared (NIR) range, which allowed visualization of PPy NP-containing agar gel embedded in chicken breast muscle at a depth of similar to 4.3 cm. Compared with PAT images based on the intrinsic optical contrast in mice, the PAT images acquired within 1 h after intravenous administration of PPy NPs showed the brain vasculature with greater clarity than hemoglobin in blood. Preliminary results showed no acute toxicity to the vital organs (heart, liver, spleen, lungs and kidneys) in mice following a single imaging dose of PPy NPs. Our results indicate that PPy NPs are promising contrast agents for PAT with good biocompatibility, high spatial resolution and enhanced sensitivity.

语种: 英语
所属项目编号: 81225011 ; 81230036 ; 61078073 ; 2011CB707502
项目资助者: National Natural Science Foundation ; State Key Program of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program)
WOS记录号: WOS:000318362400061
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68106
Appears in Collections:北京大学第三临床医学院_超声诊断科_期刊论文

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作者单位: 1.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
2.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China
3.Peking Univ, Hosp 3, Dept Ultrasonog, Beijing 100083, Peoples R China

Recommended Citation:
Zha, Zhengbao,Deng, Zijian,Li, Yanyan,et al. Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging[J]. NANOSCALE,2013,5(10):4462-4467.
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