IR@PKUHSC  > 北京大学第三临床医学院  > 超声诊断科
学科主题临床医学
Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging
Zha, Zhengbao2; Deng, Zijian1; Li, Yanyan2; Li, Changhui1; Wang, Jinrui3; Wang, Shumin3; Qu, Enze3; Dai, Zhifei1
刊名NANOSCALE
2013
DOI10.1039/c3nr00627a
5期:10页:4462-4467
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]SENTINEL LYMPH-NODE ; IN-VIVO ; CARBON NANOTUBES ; GOLD NANOCAGES ; TOMOGRAPHY ; PARTICLES ; THERAPY ; CANCER ; BRAIN ; LIGHT
英文摘要

Photoacoustic tomography (PAT) has emerged as a hybrid, nonionizing imaging modality because of its satisfactory spatial resolution and high soft tissue contrast. Here, we demonstrate the application of a novel organic PAT contrast agent based on polypyrrole nanoparticles (PPy NPs). Monodisperse PPy NPs are similar to 46 nm in diameter with strong absorption in the near-infrared (NIR) range, which allowed visualization of PPy NP-containing agar gel embedded in chicken breast muscle at a depth of similar to 4.3 cm. Compared with PAT images based on the intrinsic optical contrast in mice, the PAT images acquired within 1 h after intravenous administration of PPy NPs showed the brain vasculature with greater clarity than hemoglobin in blood. Preliminary results showed no acute toxicity to the vital organs (heart, liver, spleen, lungs and kidneys) in mice following a single imaging dose of PPy NPs. Our results indicate that PPy NPs are promising contrast agents for PAT with good biocompatibility, high spatial resolution and enhanced sensitivity.

语种英语
WOS记录号WOS:000318362400061
项目编号81225011 ; 81230036 ; 61078073 ; 2011CB707502
资助机构National Natural Science Foundation ; State Key Program of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program)
引用统计
被引频次:110[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68106
专题北京大学第三临床医学院_超声诊断科
作者单位1.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
2.Harbin Inst Technol, Sch Life Sci & Technol, Harbin 150080, Peoples R China
3.Peking Univ, Hosp 3, Dept Ultrasonog, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zha, Zhengbao,Deng, Zijian,Li, Yanyan,et al. Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging[J]. NANOSCALE,2013,5(10):4462-4467.
APA Zha, Zhengbao.,Deng, Zijian.,Li, Yanyan.,Li, Changhui.,Wang, Jinrui.,...&Dai, Zhifei.(2013).Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging.NANOSCALE,5(10),4462-4467.
MLA Zha, Zhengbao,et al."Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging".NANOSCALE 5.10(2013):4462-4467.
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