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学科主题: 基础医学
题名:
Modulation by clamping: Kv4 and KChIP interactions
作者: Wang, KeWei1,2
关键词: Kv4 ; KChIPs ; crystal structure ; T1 domain ; Kv4 and KChIP interaction
刊名: NEUROCHEMICAL RESEARCH
发表日期: 2008-10-01
DOI: 10.1007/s11064-008-9705-x
卷: 33, 期:10, 页:1964-1969
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: SHAKER POTASSIUM CHANNEL ; GATED K+ CHANNELS ; 3-DIMENSIONAL STRUCTURE ; MOLECULAR-PROPERTIES ; MAMMALIAN BRAIN ; TERMINAL DOMAIN ; I-TO ; INACTIVATION ; GENE ; EXPRESSION
英文摘要:

The rapidly inactivating (A-type) potassium channels regulate membrane excitability that defines the fundamental mechanism of neuronal functions such as pain signaling. Cytosolic Kv channel-interacting proteins KChIPs that belong to neuronal calcium sensor (NCS) family of calcium binding EF-hand proteins co-assemble with Kv4 (Shal) alpha subunits to form a native complex that encodes major components of neuronal somatodendritic A-type K(+) current, I(SA), in neurons and transient outward current, I(TO), in cardiac myocytes. The specific binding of auxiliary KChIPs to the Kv4 N-terminus results in modulation of gating properties, surface expression and subunit assembly of Kv4 channels. Here, I attempt to emphasize the interaction between KChIPs and Kv4 based on recent progress made in understanding the structure complex in which a single KChIP1 molecule laterally clamps two neighboring Kv4.3 N-termini in a 4:4 manner. Greater insights into molecular mechanism between KChIPs and Kv4 interaction may provide therapeutic potentials of designing compounds aimed at disrupting the protein-protein interaction for treatment of membrane excitability-related disorders.

语种: 英语
所属项目编号: 30630017 ; 2006AA02Z183 ; 2007CB512100
项目资助者: National Science Foundation of China ; Ministry of Science Technology of China
WOS记录号: WOS:000259190900009
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68108
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Key Lab Neurosci,Minist Educ,Ctr Protein Sci, Beijing 100083, Peoples R China

Recommended Citation:
Wang, KeWei. Modulation by clamping: Kv4 and KChIP interactions[J]. NEUROCHEMICAL RESEARCH,2008,33(10):1964-1969.
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