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学科主题基础医学
Inactivation of bad by site-specific phosphorylation: The checkpoint for ischemic astrocytes to initiate or resist apoptosis
Chen, XQ; Lau, LT; Fung, YWW; Yu, ACH
关键词ischemia astrocyte bad apoptosis LY294002 U0126
刊名JOURNAL OF NEUROSCIENCE RESEARCH
2005-03-15
DOI10.1002/jnr.20396
79期:6页:798-808
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CEREBRAL-ARTERY OCCLUSION ; IN-VITRO ISCHEMIA ; PRIMARY CULTURES ; CELL-DEATH ; DNA FRAGMENTATION ; ACTIVATION ; BCL-2 ; NEURONS ; PROTEIN ; INJURY
英文摘要

Bcl-2-associated death protein (Bad), a member of the Bcl family, directs astrocytes in primary cultures to enter or resist apoptosis during ischemia in vitro. Under ischemia, Bad was the only Bcl family member whose expression was upregulated significantly during the early stages of an ischemic insult. Increased endogenous Bad was translocated from the cytoplasm to mitochondria to induce apoptosis in astrocytes. Concurrently, ischemia also induced Bad phosphorylation specifically on Ser112 to promote survival. This site-specific phosphorylation of Bad was mediated by an early activation of the mitogen-activated protein kinase/extracellular signal-regulated protein kinase (MAPK/ERK) intracellular signaling pathway. This study demonstrates that ischemia-induced Bad plays a dual role in determining whether astrocytes enter or resist apoptosis after an ischemic insult. (C) 2005 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000227364700008
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68109
专题基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
2.Minist Educ, Key Lab Neurosci, PKU, Beijing, Peoples R China
3.Hong Kong DNA Chips Ltd, Hong Kong, Hong Kong, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Beijing 100083, Peoples R China
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Chen, XQ,Lau, LT,Fung, YWW,et al. Inactivation of bad by site-specific phosphorylation: The checkpoint for ischemic astrocytes to initiate or resist apoptosis[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2005,79(6):798-808.
APA Chen, XQ,Lau, LT,Fung, YWW,&Yu, ACH.(2005).Inactivation of bad by site-specific phosphorylation: The checkpoint for ischemic astrocytes to initiate or resist apoptosis.JOURNAL OF NEUROSCIENCE RESEARCH,79(6),798-808.
MLA Chen, XQ,et al."Inactivation of bad by site-specific phosphorylation: The checkpoint for ischemic astrocytes to initiate or resist apoptosis".JOURNAL OF NEUROSCIENCE RESEARCH 79.6(2005):798-808.
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