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学科主题: 基础医学
题名:
Immunological Responses against SARS-Coronavirus Infection in Humans
作者: Xu, Xiaojun; Gao, Xiao-Ming
关键词: SARS ; coronavirus ; immune responses ; infection
刊名: CELLULAR & MOLECULAR IMMUNOLOGY
发表日期: 2004-04-01
卷: 1, 期:2, 页:119-122
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
英文摘要:

Since the outbreak of a SARS epidemic last year, significant advances have been made on our understanding of the mechanisms of interaction between the SARS coronavirus (CoV) and the immune system. Strong humoral responses have been found in most patients following SARS-CoV infection, with high titers of neutralizing Abs present in their convalescent sera. The nucleocapsid (N) and spike (S) proteins of SARS-CoV appear to be the dominant antigens recognized by serum Abs. CD4(+) T cell responses against the N protein have been observed in SARS patients and an HLA-A2-restricted cytotoxic T lymphocyte epitope in the S protein has been identified. It is likely that the immune responses induced by SARS-CoV infection could also cause pathological damage to the host, especially in the case of proinflammatory cytokines. There is also evidence suggesting that SARS-CoV might be able to directly invade cells of the immune system. Our understanding on the interaction between SARS-CoV, the immune system and local tissues is essential to future diagnosis, control and treatment of this very contagious disease.

语种: 英语
WOS记录号: WOS:000208922200006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68115
Appears in Collections:基础医学院_免疫学系_期刊论文

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ImmunologicalRes_省略_nfectioninHumans_.pdf(275KB)期刊论文作者接受稿限制开放 联系获取全文

作者单位: Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Immunol, Beijing 100083, Peoples R China

Recommended Citation:
Xu, Xiaojun,Gao, Xiao-Ming. Immunological Responses against SARS-Coronavirus Infection in Humans[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2004,1(2):119-122.
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