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学科主题基础医学
Immunological Responses against SARS-Coronavirus Infection in Humans
Xu, Xiaojun; Gao, Xiao-Ming
关键词SARS coronavirus immune responses infection
刊名CELLULAR & MOLECULAR IMMUNOLOGY
2004-04-01
1期:2页:119-122
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
英文摘要

Since the outbreak of a SARS epidemic last year, significant advances have been made on our understanding of the mechanisms of interaction between the SARS coronavirus (CoV) and the immune system. Strong humoral responses have been found in most patients following SARS-CoV infection, with high titers of neutralizing Abs present in their convalescent sera. The nucleocapsid (N) and spike (S) proteins of SARS-CoV appear to be the dominant antigens recognized by serum Abs. CD4(+) T cell responses against the N protein have been observed in SARS patients and an HLA-A2-restricted cytotoxic T lymphocyte epitope in the S protein has been identified. It is likely that the immune responses induced by SARS-CoV infection could also cause pathological damage to the host, especially in the case of proinflammatory cytokines. There is also evidence suggesting that SARS-CoV might be able to directly invade cells of the immune system. Our understanding on the interaction between SARS-CoV, the immune system and local tissues is essential to future diagnosis, control and treatment of this very contagious disease.

语种英语
WOS记录号WOS:000208922200006
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68115
专题北京大学基础医学院_免疫学系
作者单位Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Immunol, Beijing 100083, Peoples R China
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GB/T 7714
Xu, Xiaojun,Gao, Xiao-Ming. Immunological Responses against SARS-Coronavirus Infection in Humans[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2004,1(2):119-122.
APA Xu, Xiaojun,&Gao, Xiao-Ming.(2004).Immunological Responses against SARS-Coronavirus Infection in Humans.CELLULAR & MOLECULAR IMMUNOLOGY,1(2),119-122.
MLA Xu, Xiaojun,et al."Immunological Responses against SARS-Coronavirus Infection in Humans".CELLULAR & MOLECULAR IMMUNOLOGY 1.2(2004):119-122.
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