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Influence of age and gender on Doppler index of diastolic function in Chinese hypertensive patients
Zhu, D.1,2,3; Chen, B.1,2,3; Feng, X.1,2,3; Li, Z.1,2,3; Li, W.1,2,3; Nie, Y.1,2,3; Ma, X.1,2,3; Yu, Y.1,2,3; Gao, W.1,2,3
关键词Aging Women Left ventricular diastolic function Echocardiography
刊名IRISH JOURNAL OF MEDICAL SCIENCE
2015-12-01
DOI10.1007/s11845-014-1173-5
184期:4页:791-797
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
资助者National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education
研究领域[WOS]General & Internal Medicine
关键词[WOS]VENTRICULAR SYSTOLIC FUNCTION ; PRESERVED EJECTION FRACTION ; MITRAL ANNULUS VELOCITY ; HEART-FAILURE ; TISSUE DOPPLER ; BLOOD-PRESSURE ; POSTMENOPAUSAL WOMEN ; ECHOCARDIOGRAPHY ; ESTROGEN ; CATHETERIZATION
英文摘要

This paper explores age- and gender-specific changes in Doppler echocardiographic index-E′ of left ventricular diastolic function.

The study involved 366 hypertensive patients (197 men and 169 women) who were aged from 20 to 90 years (mean 58.60 +/- A 15.68 years), without a diagnosis of any other disease. Early diastolic mitral inflow velocity (E), late diastolic mitral annular velocity (A), and E/A ratio were measured with pulse wave Doppler. Early diastolic mitral annular velocity (E′) and E/E′ ratios were measured with tissue Doppler imaging of lateral mitral annulus. Diastolic indices were highly correlated with age.

Among those aged 20-29, E′ was significantly higher in female than in male. In patients aged 30-39, 40-49, 50-59, 60-69 and 70-79 years, E′ was similar in both genders. Among those aged 80-89 years, E′ was significantly lower in female than in male. Overall (n = 366) predictors of the lowest quartile of E′ (E′ < 8.00 cm/s) were age (P < 0.0001; chi (2) = 67.35; OR 1.28; 95 % CI 1.26-1.30) and female gender (P < 0.05; chi (2) = 5.76; OR 1.56; 95 % CI 1.19-1.94).

Age-related changes in diastolic indices correlated with gender among hypertensive patients. Diastolic function deteriorated more significantly among elderly women compared with elderly men. The study may explain the increased incidence of diastolic heart failure in elderly women with hypertension.

语种英语
所属项目编号81200167 ; 20120001120131
资助者National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education ; National Natural Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education
WOS记录号WOS:000363248100011
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68118
专题北京大学第三临床医学院_心血管内科
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
3.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhu, D.,Chen, B.,Feng, X.,et al. Influence of age and gender on Doppler index of diastolic function in Chinese hypertensive patients[J]. IRISH JOURNAL OF MEDICAL SCIENCE,2015,184(4):791-797.
APA Zhu, D..,Chen, B..,Feng, X..,Li, Z..,Li, W..,...&Gao, W..(2015).Influence of age and gender on Doppler index of diastolic function in Chinese hypertensive patients.IRISH JOURNAL OF MEDICAL SCIENCE,184(4),791-797.
MLA Zhu, D.,et al."Influence of age and gender on Doppler index of diastolic function in Chinese hypertensive patients".IRISH JOURNAL OF MEDICAL SCIENCE 184.4(2015):791-797.
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