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学科主题: 临床医学
题名:
ER-alpha 36, a novel variant of estrogen receptor alpha, is involved in EGFR-related carcinogenesis in endometrial cancer
作者: Tu, Bin-Bin1; Lin, Sheng-Li2; Yan, Li-Ying1; Wang, Zhao-Yi3; Sun, Qing-Yuan2; Qiao, Jie1
关键词: endometrial cancer ; epidermal growth factor receptor ; estrogen receptor-alpha 36 ; estrogen receptor-alpha 66 ; MAPK/ERK pathway
刊名: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
发表日期: 2011-09-01
DOI: 10.1016/j.ajog.2011.04.015
卷: 205, 期:3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology
研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: GROWTH-FACTOR RECEPTOR ; ACTIVATED PROTEIN-KINASE ; ER-ALPHA ; BREAST-CANCER ; EXPRESSION ; CELLS ; PHOSPHORYLATION ; CARCINOMA ; PATHWAY
英文摘要:

OBJECTIVE: To explore the role of estrogen receptor-alpha 36 (ER-alpha 36) in epidermal growth factor receptor (EGFR)-related carcinogenesis in endometrial cancer.

STUDY DESIGN: The expression of ER-alpha 36, EGFR, and phospho-extracellular signal-regulated kinase was analyzed using immunohistochemistry in endometrial cancer samples. The cellular localization of ER-alpha 36 and EGFR was determined using immunofluorescence in the endometrial cancer Hec1A cells. The level of phospho-extracellular signal- regulated kinase of Hec1A cells was determined using Western blotting after treatment with epidermal growth factor.

RESULTS: Positive rate of ER-alpha 36 was increased in high-stage (P = .03) and high-grade (P = .224) endometrial cancer; expression of ER-alpha 36 and EGFR exhibited a significant positive correlation (r = 0.334, P = .025) and they showed substantial colocalization on the plasma membrane of glandular cells; phospho-extracellular signal-regulated kinase positive rate in ER-alpha 36 positive group and EGFR positive group was higher than that of ER-alpha 36 negative group (P = .014) and EGFR negative group (P = .016); finally, ER-alpha 36 mediated epidermal growth factor-stimulated extracellular signal-regulated kinase activation in Hec1A cells.

CONCLUSION: ER-alpha 36 mediates EGFR-related extracellular signal-regulated kinase activation in endometrial cancer.

语种: 英语
所属项目编号: 30825038 ; 2007BAI04B04 ; 20090001110090
项目资助者: Ministry of Science and Technology of China ; Chinese Ministry of Education
WOS记录号: WOS:000294330000031
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68124
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Peking Univ, Dept Obstet & Gynecol, Reprod Med Ctr, Hosp 3, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China
3.Creighton Univ, Sch Med, Dept Med Microbiol & Immunol, Omaha, NE USA

Recommended Citation:
Tu, Bin-Bin,Lin, Sheng-Li,Yan, Li-Ying,et al. ER-alpha 36, a novel variant of estrogen receptor alpha, is involved in EGFR-related carcinogenesis in endometrial cancer[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY,2011,205(3).
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