北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 生殖医学中心  > 期刊论文
学科主题: 临床医学
题名:
ER-alpha 36, a novel variant of estrogen receptor alpha, is involved in EGFR-related carcinogenesis in endometrial cancer
作者: Tu, Bin-Bin1; Lin, Sheng-Li2; Yan, Li-Ying1; Wang, Zhao-Yi3; Sun, Qing-Yuan2; Qiao, Jie1
关键词: endometrial cancer ; epidermal growth factor receptor ; estrogen receptor-alpha 36 ; estrogen receptor-alpha 66 ; MAPK/ERK pathway
刊名: AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
发表日期: 2011-09-01
DOI: 10.1016/j.ajog.2011.04.015
卷: 205, 期:3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology
研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: GROWTH-FACTOR RECEPTOR ; ACTIVATED PROTEIN-KINASE ; ER-ALPHA ; BREAST-CANCER ; EXPRESSION ; CELLS ; PHOSPHORYLATION ; CARCINOMA ; PATHWAY
英文摘要:

OBJECTIVE: To explore the role of estrogen receptor-alpha 36 (ER-alpha 36) in epidermal growth factor receptor (EGFR)-related carcinogenesis in endometrial cancer.

STUDY DESIGN: The expression of ER-alpha 36, EGFR, and phospho-extracellular signal-regulated kinase was analyzed using immunohistochemistry in endometrial cancer samples. The cellular localization of ER-alpha 36 and EGFR was determined using immunofluorescence in the endometrial cancer Hec1A cells. The level of phospho-extracellular signal- regulated kinase of Hec1A cells was determined using Western blotting after treatment with epidermal growth factor.

RESULTS: Positive rate of ER-alpha 36 was increased in high-stage (P = .03) and high-grade (P = .224) endometrial cancer; expression of ER-alpha 36 and EGFR exhibited a significant positive correlation (r = 0.334, P = .025) and they showed substantial colocalization on the plasma membrane of glandular cells; phospho-extracellular signal-regulated kinase positive rate in ER-alpha 36 positive group and EGFR positive group was higher than that of ER-alpha 36 negative group (P = .014) and EGFR negative group (P = .016); finally, ER-alpha 36 mediated epidermal growth factor-stimulated extracellular signal-regulated kinase activation in Hec1A cells.

CONCLUSION: ER-alpha 36 mediates EGFR-related extracellular signal-regulated kinase activation in endometrial cancer.

语种: 英语
所属项目编号: 30825038 ; 2007BAI04B04 ; 20090001110090
项目资助者: Ministry of Science and Technology of China ; Chinese Ministry of Education
WOS记录号: WOS:000294330000031
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68124
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Obstet & Gynecol, Reprod Med Ctr, Hosp 3, Beijing 100191, Peoples R China
2.Chinese Acad Sci, Inst Zool, State Key Lab Reprod Biol, Beijing 100101, Peoples R China
3.Creighton Univ, Sch Med, Dept Med Microbiol & Immunol, Omaha, NE USA

Recommended Citation:
Tu, Bin-Bin,Lin, Sheng-Li,Yan, Li-Ying,et al. ER-alpha 36, a novel variant of estrogen receptor alpha, is involved in EGFR-related carcinogenesis in endometrial cancer[J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY,2011,205(3).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Tu, Bin-Bin]'s Articles
[Lin, Sheng-Li]'s Articles
[Yan, Li-Ying]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Tu, Bin-Bin]‘s Articles
[Lin, Sheng-Li]‘s Articles
[Yan, Li-Ying]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace