IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Evolution of glucose utilization: Glucokinase and glucokinase regulator protein
Irwin, David M.1,2,3; Tan, Huanran3
关键词Glucokinase (GCK) Hexokinase (HK) Glucokinase regulatory protein (GCKR) Liver Glucose
刊名MOLECULAR PHYLOGENETICS AND EVOLUTION
2014
DOI10.1016/j.ympev.2013.09.016
70页:195-203
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
资助者CIHR-NSFC China-Canada Joint Health Research from the National Science Foundation of China ; Canadian Institutes for Health Research ; CIHR-NSFC China-Canada Joint Health Research from the National Science Foundation of China ; Canadian Institutes for Health Research
研究领域[WOS]Biochemistry & Molecular Biology ; Evolutionary Biology ; Genetics & Heredity
关键词[WOS]AMINO-ACID-SEQUENCE ; RAT-BRAIN HEXOKINASE ; C-TERMINAL HALVES ; MAMMALIAN HEXOKINASE ; CLONED CDNA ; GLYCOGEN-METABOLISM ; TISSUE DISTRIBUTION ; GLUCAGON-SECRETION ; GILTHEAD SEABREAM ; LIVER GLUCOKINASE
英文摘要

Glucose is an essential nutrient that must be distributed throughout the body to provide energy to sustain physiological functions. Glucose is delivered to distant tissues via be blood stream, and complex systems have evolved to maintain the levels of glucose within a narrow physiological range. Phosphorylation of glucose, by glucokinase, is an essential component of glucose homeostasis, both from the regulatory and metabolic point-of-view. Here we review the evolution of glucose utilization from the perspective of glucokinase. We discuss the origin of glucokinase, its evolution within the hexokinase gene family, and the evolution of its interacting regulatory partner, glucokinase regulatory protein (GCKR). Evolution of the structure and sequence of both glucokinase and GCKR have been necessary to optimize glucokinase in its role in glucose metabolism. (C) 2013 Elsevier Inc. All rights reserved.

语种英语
所属项目编号81061120525 ; CCI-109605
资助者CIHR-NSFC China-Canada Joint Health Research from the National Science Foundation of China ; Canadian Institutes for Health Research ; CIHR-NSFC China-Canada Joint Health Research from the National Science Foundation of China ; Canadian Institutes for Health Research
WOS记录号WOS:000328441100021
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68125
专题北京大学基础医学院_药理学系
作者单位1.Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada
2.Univ Toronto, Banting & Best Diabet Ctr, Toronto, ON M5S 1A8, Canada
3.Peking Univ, Hlth Sci Ctr, Dept Pharmacol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Irwin, David M.,Tan, Huanran. Evolution of glucose utilization: Glucokinase and glucokinase regulator protein[J]. MOLECULAR PHYLOGENETICS AND EVOLUTION,2014,70:195-203.
APA Irwin, David M.,&Tan, Huanran.(2014).Evolution of glucose utilization: Glucokinase and glucokinase regulator protein.MOLECULAR PHYLOGENETICS AND EVOLUTION,70,195-203.
MLA Irwin, David M.,et al."Evolution of glucose utilization: Glucokinase and glucokinase regulator protein".MOLECULAR PHYLOGENETICS AND EVOLUTION 70(2014):195-203.
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