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学科主题: 基础医学
题名:
Clinical significance of the reduction of UT-B expression in urothelial carcinoma of the bladder
作者: Li, Chun1; Xue, Haogang1; Lei, Yanming2; Zhu, Jianqiang1; Yang, Baoxue3,4; Gai, Xiaodong1
关键词: Bladder cancer ; Urea transporter B ; Urothelial carcinoma ; lmmunohistochemistry
刊名: PATHOLOGY RESEARCH AND PRACTICE
发表日期: 2014
DOI: 10.1016/j.prp.2014.09.012
卷: 210, 期:12, 页:799-803
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: URINARY CONCENTRATING ABILITY ; GENOME-WIDE ASSOCIATION ; UREA-TRANSPORTER-B ; CANCER ; MICE ; ERYTHROCYTES ; LOCALIZATION ; MUTATION ; SLC14A1 ; TISSUES
英文摘要:

Urea transporter B (UT-B) is a membrane protein and plays an important role in regulating urea concentration in bladder urothelial cells. It has been reported that UT-B gene mutations were related to bladder carcinogenesis, and UT-B deletion could induce DNA damage and apoptosis in bladder urothelium. However, the functions and clinical significance of UT-B in human bladder cancer remain unknown. The most common type of bladder cancer is urothelial carcinoma (UC). We hypothesized that UT-B expression was related to bladder UC progress. In this study, UT-B was detected using immunohistochemistry in 52 paraffin-embedded specimens of bladder UC and 10 normal urothelium specimens. The results showed that UT-B protein expression in UC tumor cells was significantly lower as compared with normal urothelial cells (P = 0.021). UT-B protein expression was significantly reduced with increasing histological grade (P = 0.010). UT-B protein expression in muscle-invasive stage was significantly lower than in non-muscle-invasive stage (P = 0.014). Taken together, our data suggest that the reduction or loss of UT-B expression may be related to the incidence, progression and invasiveness of bladder UC. UT-B may be a novel diagnostic or prognostic biomarker, as well as a potential therapeutic target in UC of the bladder. (C) 2014 Elsevier GmbH. All rights reserved.

语种: 英语
所属项目编号: 2013193 ; 201262501 ; 81170632
项目资助者: Department of Education of Jilin Province ; Science and Technology Project of Jilin City ; National Natural Science Foundation of China
WOS记录号: WOS:000346454200004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68132
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.CNPC Jilin, Gen Hosp, Dept Pathol, Jilin, Peoples R China
2.State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China
3.Beihua Univ, Sch Basic Med Sci, Dept Immunol, Jilin 132013, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100871, Peoples R China

Recommended Citation:
Li, Chun,Xue, Haogang,Lei, Yanming,et al. Clinical significance of the reduction of UT-B expression in urothelial carcinoma of the bladder[J]. PATHOLOGY RESEARCH AND PRACTICE,2014,210(12):799-803.
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