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学科主题基础医学
Clinical significance of the reduction of UT-B expression in urothelial carcinoma of the bladder
Li, Chun1; Xue, Haogang1; Lei, Yanming2; Zhu, Jianqiang1; Yang, Baoxue3,4; Gai, Xiaodong1
关键词Bladder cancer Urea transporter B Urothelial carcinoma lmmunohistochemistry
刊名PATHOLOGY RESEARCH AND PRACTICE
2014
DOI10.1016/j.prp.2014.09.012
210期:12页:799-803
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]URINARY CONCENTRATING ABILITY ; GENOME-WIDE ASSOCIATION ; UREA-TRANSPORTER-B ; CANCER ; MICE ; ERYTHROCYTES ; LOCALIZATION ; MUTATION ; SLC14A1 ; TISSUES
英文摘要

Urea transporter B (UT-B) is a membrane protein and plays an important role in regulating urea concentration in bladder urothelial cells. It has been reported that UT-B gene mutations were related to bladder carcinogenesis, and UT-B deletion could induce DNA damage and apoptosis in bladder urothelium. However, the functions and clinical significance of UT-B in human bladder cancer remain unknown. The most common type of bladder cancer is urothelial carcinoma (UC). We hypothesized that UT-B expression was related to bladder UC progress. In this study, UT-B was detected using immunohistochemistry in 52 paraffin-embedded specimens of bladder UC and 10 normal urothelium specimens. The results showed that UT-B protein expression in UC tumor cells was significantly lower as compared with normal urothelial cells (P = 0.021). UT-B protein expression was significantly reduced with increasing histological grade (P = 0.010). UT-B protein expression in muscle-invasive stage was significantly lower than in non-muscle-invasive stage (P = 0.014). Taken together, our data suggest that the reduction or loss of UT-B expression may be related to the incidence, progression and invasiveness of bladder UC. UT-B may be a novel diagnostic or prognostic biomarker, as well as a potential therapeutic target in UC of the bladder. (C) 2014 Elsevier GmbH. All rights reserved.

语种英语
WOS记录号WOS:000346454200004
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被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68132
专题北京大学基础医学院_药理学系
北京大学基础医学院
作者单位1.CNPC Jilin, Gen Hosp, Dept Pathol, Jilin, Peoples R China
2.State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China
3.Beihua Univ, Sch Basic Med Sci, Dept Immunol, Jilin 132013, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100871, Peoples R China
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GB/T 7714
Li, Chun,Xue, Haogang,Lei, Yanming,et al. Clinical significance of the reduction of UT-B expression in urothelial carcinoma of the bladder[J]. PATHOLOGY RESEARCH AND PRACTICE,2014,210(12):799-803.
APA Li, Chun,Xue, Haogang,Lei, Yanming,Zhu, Jianqiang,Yang, Baoxue,&Gai, Xiaodong.(2014).Clinical significance of the reduction of UT-B expression in urothelial carcinoma of the bladder.PATHOLOGY RESEARCH AND PRACTICE,210(12),799-803.
MLA Li, Chun,et al."Clinical significance of the reduction of UT-B expression in urothelial carcinoma of the bladder".PATHOLOGY RESEARCH AND PRACTICE 210.12(2014):799-803.
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