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学科主题: 临床医学
题名:
Inhibition of STAT5a by Naa10p contributes to decreased breast cancer metastasis
作者: Zeng, Yan1,2; Min, Li1; Han, Yong1; Meng, Lin3; Liu, Caiyun1; Xie, Yuntao4; Dong, Bin5; Wang, Lixin3; Jiang, Beihai6; Xu, Huiyu1; Zhuang, Qing1; Zhao, Chuanke3; Qu, Like3; Shou, Chengchao1
刊名: CARCINOGENESIS
发表日期: 2014-10-01
DOI: 10.1093/carcin/bgu132
卷: 35, 期:10, 页:2244-2253
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ACETYLTRANSFERASE 10 PROTEIN ; SIGNAL TRANSDUCER ; TRANSACTIVATION DOMAIN ; TRANSCRIPTION 5A/B ; CELL-PROLIFERATION ; NEGATIVE REGULATOR ; GENE-EXPRESSION ; POOR-PROGNOSIS ; TUMORIGENESIS ; ACTIVATOR
英文摘要:

N-alpha-Acetyltransferase 10 protein (Naa10p, also called arrest-defective 1), the catalytic subunit of N-acetyltransferase A, is a critical regulator of cell death and proliferation. Naa10p is also shown to regulate cancer metastasis by inhibiting cell motility; however, its role in cancer metastasis is not fully understood. In this study, we found that high expression of Naa10p is positively correlated with the survival of patients with breast cancer, whereas negatively correlated with lymph node metastasis. Naa10p inhibits breast cancer cell migration and invasion in vitro and decreases the xenograft growth and metastasis in nude mice. Microarray screening revealed that Naa10p downregulates inhibitors of differentiation 1 (ID1) expression. Naa10p binds to signal transducer and activator of transcription 5a (STAT5a) and decreases STAT5a-stimulated ID1 expression in an acetyltransferase-independent manner. Moreover, Naa10p antagonizes Janus kinase 2-STAT5a signaling by lowering p65-activated interleukin-1 beta expression. Our results demonstrate a novel mechanism through which Naa10p inhibits the metastasis of breast cancer cells by targeting STAT5a.

语种: 英语
所属项目编号: 2009CB521805 ; 2013CB910504 ; 81071658
项目资助者: National 973 Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000345830400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68142
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.Peking Univ Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
2.Shihezi Univ, Sch Med, Key Lab Xinjiang Endem & Ethn Dis, Shihezi 832000, Xinjiang, Peoples R China
3.Peking Univ Canc Hosp & Inst, Dept Biochem & Mol Biol, Beijing 100142, Peoples R China
4.Peking Univ Canc Hosp & Inst, Breast Canc Ctr, Beijing 100142, Peoples R China
5.Peking Univ Canc Hosp & Inst, Dept Pathol, Beijing 100142, Peoples R China
6.Peking Univ Canc Hosp & Inst, Dept Minimally Invas Gastrointestinal Surg, Beijing 100142, Peoples R China

Recommended Citation:
Zeng, Yan,Min, Li,Han, Yong,et al. Inhibition of STAT5a by Naa10p contributes to decreased breast cancer metastasis[J]. CARCINOGENESIS,2014,35(10):2244-2253.
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