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学科主题基础医学
Manipulation of and Sustained Effects on the Human Brain Induced by Different Modalities of Acupuncture: An fMRI Study
Jiang, Yin1,2,3,4; Wang, Hong5; Liu, Zhenyu6; Dong, Yuru5; Dong, Yue2; Xiang, Xiaohui1,2,3,4; Bai, Lijun6; Tian, Jie6; Wu, Liuzhen1,2,3,4; Han, Jisheng1,2,3,4; Cui, Cailian1,2,3,4
刊名PLOS ONE
2013-06-28
DOI10.1371/journal.pone.0066815
8期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]ELECTRICAL ACUPOINT STIMULATION ; DEFAULT-MODE ; MANUAL ACUPUNCTURE ; NETWORK ; ELECTROACUPUNCTURE ; CONNECTIVITY ; PAIN ; PERCEPTION ; ACTIVATION ; CHINESE
英文摘要

The javascript: void(0) manipulation and sustained effects of acupuncture have been investigated in multiple studies, but several findings are inconsistent with one another. One possible explanation for these discrepancies is that different modalities of acupuncture were utilized in these studies. In the present study, we investigated both the manipulation and sustained effects of acupuncture in different modalities, including manual acupuncture (MA), electroacupuncture (EA) and transcutaneous electrical acupoint stimulation (TEAS). MA, EA, TEAS and sensory control stimulation were applied to 18 healthy subjects, and combined block-designed and resting-state fMRI scans were performed. In analyzing these data, the block-designed datasets were used to assess the manipulation effect by employing a modified general linear model. The data from the resting states, before and after stimulation, were used to explore the brain networks involved in the sustained effect. The results showed that the two 1-min stimulation periods produced similar activation patterns in the sensory control with positive activation in the sensorimotor areas and negative activation in the default mode areas. Although similar patterns could be detected in the first stimulation period in MA, EA and TEAS, no positive activation result was observed in the second stimulation period, and EA showed a more extensive deactivation compared to MA and TEAS. Additionally, all three of the modalities of acupuncture stimulation could increase the instinct brain network in rest. A more secure and spatially extended connectivity of the default mode network was observed following MA and EA, and TEAS specifically increased the functional connectivity in the sensorimotor network. The present study suggested that different brain mechanisms might be recruited in different acupuncture modalities. In addition, the findings from our work could provide methodological information for further research into the mechanism of acupuncture.

语种英语
WOS记录号WOS:000321148400019
项目编号2007CB512501 ; 2013CB531905 ; 2009CB522003
资助机构National Basic Research Program of China
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68145
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100871, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing 100871, Peoples R China
3.Minist Educ Res, Key Lab Neurosci, Beijing, Peoples R China
4.Minist Publ Hlth, Beijing, Peoples R China
5.Gen Hosp Armed Police Forces, Dept Magnet Resonance, Beijing, Peoples R China
6.Chinese Acad Sci, Inst Automat, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Jiang, Yin,Wang, Hong,Liu, Zhenyu,et al. Manipulation of and Sustained Effects on the Human Brain Induced by Different Modalities of Acupuncture: An fMRI Study[J]. PLOS ONE,2013,8(6).
APA Jiang, Yin.,Wang, Hong.,Liu, Zhenyu.,Dong, Yuru.,Dong, Yue.,...&Cui, Cailian.(2013).Manipulation of and Sustained Effects on the Human Brain Induced by Different Modalities of Acupuncture: An fMRI Study.PLOS ONE,8(6).
MLA Jiang, Yin,et al."Manipulation of and Sustained Effects on the Human Brain Induced by Different Modalities of Acupuncture: An fMRI Study".PLOS ONE 8.6(2013).
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