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学科主题: 药学
题名:
Aristololactams and aporphines from the stems of Fissistigma oldhamii (Annonaceae)
作者: Ge, Yue-Wei1,2; Zhu, Shu2; Shang, Ming-Ying1; Zang, Xin-Yu1; Wang, Xuan1; Bai, Yan-Jing2; Li, Li3,4; Komatsu, Katsuko2; Cai, Shao-Qing1
关键词: Fissistigma oldhamii ; Annonaceae ; Aporphine ; Aristololactam GI ; Fissistigamide A ; Anti-inflammatory activity
刊名: PHYTOCHEMISTRY
发表日期: 2013-02-01
DOI: 10.1016/j.phytochem.2012.09.011
卷: 86, 页:201-207
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Plant Sciences
关键词[WOS]: RHEUMATOID-ARTHRITIS ; ALKALOIDS ; CONSTITUENTS ; ARISTOLACTAMS ; LIGNANS ; MERR
英文摘要:

Two aristololactams, aristololactam GI (1) and aristololactam GII (2), and three aporphines, fissistigamide A (3), fissistigamide B (4) and fissistigmine (5), together with nineteen known alkaloids, one flavone and one anthraquinone were isolated from the ethanol extracts of the stems of Fissistigma oldhamii (Annonaceae). Their structures were elucidated primarily by analysis of NMR, IR, UV, MS and CD data. Alkaloid 1 is a chiral aristololactam formed from a phenylpropanoid derivative attached to a 3,4-dihydroxy aristololactam scaffold. The absolute configuration of 1 was determined by comparing experimental and calculated ECD spectra. The anti-inflammatory activity of the crude extracts and the five alkaloids were tested by measuring the amount of TNF-alpha and IL-6 released from LPS stimulated RAW264 cell via ELISA. The results demonstrated that the CHCl3-soluble part and alkaloid 2 exhibited significant anti-inflammatory activity in vitro in both assays. (C) 2012 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2001BA701A11-07 ; 30873466 ; 2006BAI14B01
项目资助者: State Administration of Traditional Chinese Medicine of the People&prime ; s Republic of China ; National Natural Science Foundation of China ; National Eleventh Five-Year Key Technologies R&amp ; D Programme of China ; China Scholarship Council
WOS记录号: WOS:000315017100023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68151
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Toyama Univ, Inst Nat Med, Dept Med Resources, Div Pharmacognosy, Toyama 9300194, Japan
3.Chinese Acad Med Sci, Inst Mat Med, Dept Med Chem, Beijing 100050, Peoples R China
4.Peking Union Med Coll, Beijing 100050, Peoples R China

Recommended Citation:
Ge, Yue-Wei,Zhu, Shu,Shang, Ming-Ying,et al. Aristololactams and aporphines from the stems of Fissistigma oldhamii (Annonaceae)[J]. PHYTOCHEMISTRY,2013,86:201-207.
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