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学科主题: 临床医学
题名:
Cellular traction force recovery: An optimal filtering approach in two-dimensional Fourier space
作者: Huang, Jianyong1,2; Qin, Lei2,3; Peng, Xiaoling1,2; Zhu, Tao1,2; Xiong, Chunyang1,2; Zhang, Youyi2,3; Fang, Jing1,2
关键词: Cell-substrate interaction ; Digital image correlation ; Signal-noise ratio ; Traction force microscopy
刊名: JOURNAL OF THEORETICAL BIOLOGY
发表日期: 2009-08-21
DOI: 10.1016/j.jtbi.2009.05.005
卷: 259, 期:4, 页:811-819
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biology ; Mathematical & Computational Biology
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics ; Mathematical & Computational Biology
关键词[WOS]: FLEXIBLE SUBSTRATA ; CELLS ; LOCOMOTION ; FIELDS ; ENERGY
英文摘要:

Quantitative estimation of cellular traction has significant physiological and clinical implications. As an inverse problem, traction force recovery is essentially susceptible to noise in the measured displacement data. For traditional procedure of Fourier transform traction cytometry (FTTC), noise amplification is accompanied in the force reconstruction and small tractions cannot be recovered from the displacement field with low signal-noise ratio (SNR). To improve the FTTC process, we develop an optimal filtering scheme to suppress the noise in the force reconstruction procedure. In the framework of the Wiener filtering theory, four filtering parameters are introduced in two-dimensional Fourier space and their analytical expressions are derived in terms of the minimum-mean-squared-error (MMSE) optimization criterion. The optimal filtering approach is validated with simulations and experimental data associated with the adhesion of single cardiac myocyte to elastic substrate. The results indicate that the proposed method can highly enhance SNR of the recovered forces to reveal tiny tractions in cell-substrate interaction. (C) 2009 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000274798100015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68154
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Dept Biomed Engn, Beijing 100871, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100083, Peoples R China

Recommended Citation:
Huang, Jianyong,Qin, Lei,Peng, Xiaoling,et al. Cellular traction force recovery: An optimal filtering approach in two-dimensional Fourier space[J]. JOURNAL OF THEORETICAL BIOLOGY,2009,259(4):811-819.
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