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Vascular Endothelial Growth Factor in Plasma and Vitreous Fluid of Patients with Proliferative Diabetic Retinopathy Patients after Intravitreal Injection of Bevacizumab
Ma, Yan; Zhang, Yan; Zhao, Tong; Jiang, Yan-Rong
刊名AMERICAN JOURNAL OF OPHTHALMOLOGY
2012-02-01
DOI10.1016/j.ajo.2011.08.006
153期:2页:307-313
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
资助者BEIJING MUNICIPAL NATURAL SCIENCE Foundation, Beijing, China ; National Natural Science Foundation, Beijing, China ; Peking University People&prime ; s Hospital, Beijing, China ; Ministry of Education, Beijing, China ; BEIJING MUNICIPAL NATURAL SCIENCE Foundation, Beijing, China ; National Natural Science Foundation, Beijing, China ; Peking University People&prime ; s Hospital, Beijing, China ; Ministry of Education, Beijing, China
研究领域[WOS]Ophthalmology
关键词[WOS]RETINAL NEOVASCULARIZATION ; IRIS NEOVASCULARIZATION ; PERMEABILITY FACTOR ; AVASTIN ; ANGIOGENESIS ; MODEL
英文摘要

PURPOSE: To investigate plasma and vitreous vascular endothelial growth factor (VEGF) levels after intravitreal bevacizumab (IVB) injection into eyes with proliferative diabetic retinopathy (PDR).

DESIGN: Retrospective, interventional, nonrandomized, comparative study.

METHODS: Fifty-six eyes of 56 patients with PDR and 13 eyes of 13 patients with nondiabetic ocular diseases were enrolled. Analysis included evaluation of basic clinical conditions and measurement of vitreous and plasma VEGF concentrations using enzyme-linked immunosorbent assays.

RESULTS: PDR eyes without IVB had the highest vitreous VEGF levels; the levels were significant compared with those in the recent IVB group (previous injection within 1 week), the prolonged IVB group (injection more than 1 week previously), and the nondiabetic control group (P = .001, P = .035, P < .001, respectively). The vitreous VEGF level in the recent IVB group was higher than that in prolonged IVB group (P = .035). PDR eyes without IVB had the highest plasma VEGF level, and the level was significant compared with those in the recent IVB group, the prolonged IVB group, and the nondiabetic control group (P < .001, P = .003, P < .001, respectively). The plasma VEGF level in the recent IVB group was lower than that in the prolonged IVB group (P = .003). The vitreous VEGF level was associated significantly with the plasma VEGF level (P = .002).

CONCLUSIONS: Vitreous and plasma VEGF levels were increased markedly in patients with PDR. VEGF concentrations in vitreous and plasma were decreased significantly after IVB into PDR eyes, and the effect lasted from 4.4 +/- 2.2 days to 34.8 +/- 33.7 days after injection. (Am J Ophthalmol 2012;153:307-313. (C) 2012 by Elsevier Inc. All rights reserved.)

语种英语
所属项目编号7112142 ; 81041005 ; RDB2009-42 ; 20100001110073
资助者BEIJING MUNICIPAL NATURAL SCIENCE Foundation, Beijing, China ; National Natural Science Foundation, Beijing, China ; Peking University People&prime ; s Hospital, Beijing, China ; Ministry of Education, Beijing, China ; BEIJING MUNICIPAL NATURAL SCIENCE Foundation, Beijing, China ; National Natural Science Foundation, Beijing, China ; Peking University People&prime ; s Hospital, Beijing, China ; Ministry of Education, Beijing, China
WOS记录号WOS:000299717800017
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68161
专题北京大学第二临床医学院_眼科
作者单位Peking Univ, Dept Ophthalmol, Peoples Hosp, Key Lab Vis Loss & Restorat,Minist Educ, Beijing 100044, Peoples R China
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GB/T 7714
Ma, Yan,Zhang, Yan,Zhao, Tong,et al. Vascular Endothelial Growth Factor in Plasma and Vitreous Fluid of Patients with Proliferative Diabetic Retinopathy Patients after Intravitreal Injection of Bevacizumab[J]. AMERICAN JOURNAL OF OPHTHALMOLOGY,2012,153(2):307-313.
APA Ma, Yan,Zhang, Yan,Zhao, Tong,&Jiang, Yan-Rong.(2012).Vascular Endothelial Growth Factor in Plasma and Vitreous Fluid of Patients with Proliferative Diabetic Retinopathy Patients after Intravitreal Injection of Bevacizumab.AMERICAN JOURNAL OF OPHTHALMOLOGY,153(2),307-313.
MLA Ma, Yan,et al."Vascular Endothelial Growth Factor in Plasma and Vitreous Fluid of Patients with Proliferative Diabetic Retinopathy Patients after Intravitreal Injection of Bevacizumab".AMERICAN JOURNAL OF OPHTHALMOLOGY 153.2(2012):307-313.
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