IR@PKUHSC  > 北京大学第二临床医学院  > 血液科
学科主题临床医学
Interferon alpha: the salvage therapy for patients with unsatisfactory response to minimal residual disease-directed modified donor lymphocyte infusion
Mo Xiaodong; Zhao Xiangyu; Xu Lanping; Liu Daihong; Zhang Xiaohui; Chen Huan; Wang Yu; Huang Xiaojun
关键词interferon alpha hematopoietic stem cell transplantation donor lymphocyte infusion
刊名CHINESE MEDICAL JOURNAL
2014-07-20
DOI10.3760/cma.j.issn.0366-6999.20132908
127期:14页:2583-2587
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]STEM-CELL TRANSPLANTATION ; ACUTE MYELOID-LEUKEMIA ; BONE-MARROW-TRANSPLANTATION ; COMPLETE REMISSION ; HIGH-RISK ; IN-VITRO ; RELAPSE ; IMMUNOTHERAPY
英文摘要

Background Minimal residual disease (MRD)-directedmodified donor lymphocyte infusion (mDLI) is used to treat relapse after hematopoietic stem cell transplantation (HSCT). For patients who experience an unsatisfactory response tomDLI, relapse is usually inevitable. Therefore, we sought to evaluate the efficacy ofinterferon a therapy in these patients.

Methods Regular MRD monitoring was carried out after the HSCT. The patients who were MRD-positive underwent mDLI. Patients with an unsatisfactory response to mDLI received interferon alpha therapy (3 million units, twice weekly) with regular monitoring of MRD. To ensure the immunomodulatory effects of interferon alpha, immunosuppressant treatment would be stopped before interferon alpha treatment.

Results Five patients with an unsatisfactory response to mDLI treatment received interferon alpha (3 had t(8;21) chromosomal translocation acute myeloid leukemia, and 2 had common acute leukemia). They had significantly reduced or resolved MRD. Four patients developed chronic graft-versus-host disease. Two of the 5 patients reported transient fevers, and no significant bone marrow suppression was observed. All of them were in continuous complete remission after interferon alpha treatment. The median survival time was 469 days (range 368-948 days).

Conclusions In patients with an unsatisfactory response to MRD-directed mDLI, interferon alpha may directly or indirectly induce the graft-versus-leukemia effect to improve mDLI efficacy and clear MRD.

语种英语
WOS记录号WOS:000339860900005
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68163
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Mo Xiaodong,Zhao Xiangyu,Xu Lanping,et al. Interferon alpha: the salvage therapy for patients with unsatisfactory response to minimal residual disease-directed modified donor lymphocyte infusion[J]. CHINESE MEDICAL JOURNAL,2014,127(14):2583-2587.
APA Mo Xiaodong.,Zhao Xiangyu.,Xu Lanping.,Liu Daihong.,Zhang Xiaohui.,...&Huang Xiaojun.(2014).Interferon alpha: the salvage therapy for patients with unsatisfactory response to minimal residual disease-directed modified donor lymphocyte infusion.CHINESE MEDICAL JOURNAL,127(14),2583-2587.
MLA Mo Xiaodong,et al."Interferon alpha: the salvage therapy for patients with unsatisfactory response to minimal residual disease-directed modified donor lymphocyte infusion".CHINESE MEDICAL JOURNAL 127.14(2014):2583-2587.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Mo Xiaodong]的文章
[Zhao Xiangyu]的文章
[Xu Lanping]的文章
百度学术
百度学术中相似的文章
[Mo Xiaodong]的文章
[Zhao Xiangyu]的文章
[Xu Lanping]的文章
必应学术
必应学术中相似的文章
[Mo Xiaodong]的文章
[Zhao Xiangyu]的文章
[Xu Lanping]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。