北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 期刊论文
学科主题: 基础医学
题名:
Cerebralcare Granule (R), a Chinese herb compound preparation, improves cerebral microcirculatory disorder and hippocampal CA1 neuron injury in gerbils after ischemia-reperfusion
作者: Sun, Kai2; Hu, Qin3; Zhou, Chang-Man2,3; Xu, Xiang-Shun2; Wang, Fang2; Hu, Bai-He2; Zhao, Xin-Yong2; Chang, Xin2; Chen, Chun-Hua3; Huang, Ping2; An, Li-Hua2; Liu, Yu-Ying2; Fan, Jing-Yu2; Wang, Chuan-She1,2; Yang, Lei2,3; Han, Jing-Yan1,2
关键词: Global ischemia ; Cerebral microcirculatory disturbance ; Hippocampal neuron injury ; Apoptosis ; Chinese medicine
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2010-07-20
DOI: 10.1016/j.jep.2010.05.030
卷: 130, 期:2, 页:398-406
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]: INDUCED MICROVASCULAR DYSFUNCTION ; INHIBITORY-ACTIVITY ; DRUG DISCOVERY ; RAT MESENTERY ; BRAIN-DAMAGE ; CASSIA-TORA ; IN-VITRO ; STROKE ; CONSTITUENTS ; DISTURBANCE
英文摘要:

Aim of the study: Cerebralcare Granule (R) (CG) is a Chinese herb compound preparation that has been used for treatment of cerebrovascular related diseases. However, the effect of post-treatment with CG on ischemia and reperfusion (I/R) induced cerebral injury is so far unclear.

Materials and methods: In present study, cerebral global I/R was induced in Mongolian gerbils by clamping bilateral carotid arteries for 30 min followed by reperfusion for 5 days, and CG (0.4 g/kg or 0.8 g/kg) was administrated 3 h after the initiation of reperfusion.

Results: Post-treatment with CG for 5 days attenuated the I/R-induced production of hydrogen peroxide in, leukocyte adhesion to, and albumin leakage from cerebral microvessels, and, meanwhile, protected neuron from death, reduced the number of caspase-3- and Bax-positive cells, and increased Bcl-2-positive cells in hippocampal CA1 region.

Conclusion: The results suggest that CG given after initiation of reperfusion is able to ameliorate cerebral microvascular dysfunction and hippocampal CA1 neuron damage caused by I/R. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2008ZX09401 ; 20050230
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China ; Tianjin Tasly Group, Tianjin, China
WOS记录号: WOS:000280622400029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68165
Appears in Collections:基础医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Anat, Beijing 100191, Peoples R China

Recommended Citation:
Sun, Kai,Hu, Qin,Zhou, Chang-Man,et al. Cerebralcare Granule (R), a Chinese herb compound preparation, improves cerebral microcirculatory disorder and hippocampal CA1 neuron injury in gerbils after ischemia-reperfusion[J]. JOURNAL OF ETHNOPHARMACOLOGY,2010,130(2):398-406.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Sun, Kai]'s Articles
[Hu, Qin]'s Articles
[Zhou, Chang-Man]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Sun, Kai]‘s Articles
[Hu, Qin]‘s Articles
[Zhou, Chang-Man]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace