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学科主题: 基础医学
题名:
Cerebralcare Granule (R), a Chinese herb compound preparation, improves cerebral microcirculatory disorder and hippocampal CA1 neuron injury in gerbils after ischemia-reperfusion
作者: Sun, Kai2; Hu, Qin3; Zhou, Chang-Man2,3; Xu, Xiang-Shun2; Wang, Fang2; Hu, Bai-He2; Zhao, Xin-Yong2; Chang, Xin2; Chen, Chun-Hua3; Huang, Ping2; An, Li-Hua2; Liu, Yu-Ying2; Fan, Jing-Yu2; Wang, Chuan-She1,2; Yang, Lei2,3; Han, Jing-Yan1,2
关键词: Global ischemia ; Cerebral microcirculatory disturbance ; Hippocampal neuron injury ; Apoptosis ; Chinese medicine
刊名: JOURNAL OF ETHNOPHARMACOLOGY
发表日期: 2010-07-20
DOI: 10.1016/j.jep.2010.05.030
卷: 130, 期:2, 页:398-406
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]: INDUCED MICROVASCULAR DYSFUNCTION ; INHIBITORY-ACTIVITY ; DRUG DISCOVERY ; RAT MESENTERY ; BRAIN-DAMAGE ; CASSIA-TORA ; IN-VITRO ; STROKE ; CONSTITUENTS ; DISTURBANCE
英文摘要:

Aim of the study: Cerebralcare Granule (R) (CG) is a Chinese herb compound preparation that has been used for treatment of cerebrovascular related diseases. However, the effect of post-treatment with CG on ischemia and reperfusion (I/R) induced cerebral injury is so far unclear.

Materials and methods: In present study, cerebral global I/R was induced in Mongolian gerbils by clamping bilateral carotid arteries for 30 min followed by reperfusion for 5 days, and CG (0.4 g/kg or 0.8 g/kg) was administrated 3 h after the initiation of reperfusion.

Results: Post-treatment with CG for 5 days attenuated the I/R-induced production of hydrogen peroxide in, leukocyte adhesion to, and albumin leakage from cerebral microvessels, and, meanwhile, protected neuron from death, reduced the number of caspase-3- and Bax-positive cells, and increased Bcl-2-positive cells in hippocampal CA1 region.

Conclusion: The results suggest that CG given after initiation of reperfusion is able to ameliorate cerebral microvascular dysfunction and hippocampal CA1 neuron damage caused by I/R. (C) 2010 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2008ZX09401 ; 20050230
项目资助者: Ministry of Science and Technology of the People&prime ; s Republic of China ; Tianjin Tasly Group, Tianjin, China
WOS记录号: WOS:000280622400029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68165
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Anat, Beijing 100191, Peoples R China

Recommended Citation:
Sun, Kai,Hu, Qin,Zhou, Chang-Man,et al. Cerebralcare Granule (R), a Chinese herb compound preparation, improves cerebral microcirculatory disorder and hippocampal CA1 neuron injury in gerbils after ischemia-reperfusion[J]. JOURNAL OF ETHNOPHARMACOLOGY,2010,130(2):398-406.
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