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学科主题: 临床医学
题名:
High doses of mother′s lymphocyte infusion to treat EBV-positive T-cell lymphoproliferative disorders in childhood
作者: Wang, Qian1; Liu, Hongxing2; Zhang, Xian2; Liu, Qian1; Xing, Yanping3; Zhou, Xiaoge4; Tong, Chunrong2; Zhu, Ping1
刊名: BLOOD
发表日期: 2010-12-23
DOI: 10.1182/blood-2010-01-262311
卷: 116, 期:26, 页:5941-5947
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; VERSUS-HOST-DISEASE ; FETOMATERNAL MICROCHIMERISM ; ADOPTIVE IMMUNOTHERAPY ; FETAL MICROCHIMERISM ; MALIGNANCIES ; RESPONSES ; LEUKEMIA ; INSERTION ; ANTIGENS
英文摘要:

Donor lymphocyte infusion is an alternative treatment for Epstein-Barr virus (EBV)-associated lymphoproliferative disorders (LPDs) but with risk of graft-versus-host diseases (GVHDs). According to the fetal-maternal microchimerism tolerance, we assumed that maternal lymphocyte infusion may be effective without causing GVHD. In 54 cases when a child required cytotherapy or hematopoietic stem cell transplantation, we studied the mother for child-mother microchimerism with use of insertion-deletion polymorphisms as allogeneic markers and a combination of nested polymerase chain reaction (PCR) and real-time quantitative PCR. Thirteen mothers were child-microchimerism-positive at the ratio of 10(-5)-10(-3). Among them, 5 children had non-transplant-associated, EBV+ T-cell LPD. In these 5 cases, high doses of human leukocyte antigen-haploidentical maternal peripheral blood mononuclear cells (> 10(8)/kg/infusion) were infused 1-4 times. Symptoms of all 5 patients improved between 3 and 10 days after the infusion; thereafter, 3 cases showed complete remission for 6-18 months without further therapy and 2 had partial remission. During the period of observation, none developed obvious GVHD. By quantitative PCR, in some patients maternal cells were found to be eliminated or decreased after infusions, indicating existence of host-versus-graft reaction. We suggest that high doses of mother′s lymphocyte infusion may be an effective and safe treatment for non-transplant-associated EBV+ T-cell LPD. (Blood. 2010;116(26):5941-5947)

语种: 英语
所属项目编号: 2006 DFB 31430
项目资助者: National Ministry of Science and Technology of China
WOS记录号: WOS:000285583400024
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68166
Appears in Collections:北京大学第一临床医学院_血液内科_期刊论文

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作者单位: 1.Peking Univ First Hosp, Dept Hematol, Beijing 100034, Peoples R China
2.Beijing Daopei Hosp, Hematol Labs, Beijing, Peoples R China
3.Beijing Childrens Hosp, Hematol Ctr, Beijing, Peoples R China
4.Beijing Friendship Hosp, Dept Pathol, Beijing, Peoples R China

Recommended Citation:
Wang, Qian,Liu, Hongxing,Zhang, Xian,et al. High doses of mother′s lymphocyte infusion to treat EBV-positive T-cell lymphoproliferative disorders in childhood[J]. BLOOD,2010,116(26):5941-5947.
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