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学科主题: 药学
题名:
Cluster analysis of yeast genome-wide expression patterns obtained by treating with different antifungal agents
作者: Zhang, L; Zhang, Y; Zhou, YM; An, S; Guo, DA; Zhou, YX; Zeng, LW; Cheng, J
关键词: DNA microarray ; cluster analysis ; antifungal agents
刊名: PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2002-08-01
卷: 29, 期:4, 页:538-542
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: ALLICIN
英文摘要:

To examine the application of DNA microarray in drug discovery and development, cluster analysis for genome-wide expression data was tested after Saccharomyces cerevisiae was treated with nine antifungal agents with known and unknown pharmacological mechanisms. The results indicated that antifungal agents with similar action mode were clustered together. Amphotericin B and nystatin, ketoconazole and clotrimazole have been known to have similar antifungal mechanism respectively. Consistent with their known mechanisms, amphotericin B and nystatin were clustered together; also ketoconazole and clotrimazole were clustered together based on their expression patterns. Solasodine, which was known to inhibit the synthesis of ergosterol, had a close clustering position with ketoconazole and clotrimazole group. Analyzing the relationship among the known and unknown drugs using cluster approach, It can be infered that the pharmacological mechanisms of unknown drugs from their clustering positions relating to the known drugs.

语种: 中文
WOS记录号: WOS:000177560000010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68171
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Tsing Hua Univ, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China
2.Tsing Hua Univ, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China
3.Tsing Hua Univ, Natl Engn Res Ctr Beijing Biochip Technol, Beijing 100084, Peoples R China
4.Tsing Hua Univ, Sch Med, Dept Pharmacol, Beijing 100084, Peoples R China
5.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, L,Zhang, Y,Zhou, YM,et al. Cluster analysis of yeast genome-wide expression patterns obtained by treating with different antifungal agents[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2002,29(4):538-542.
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