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学科主题基础医学
Glucose intolerance and decreased early insulin response in mice with severe hypertriglyceridemia
Ding, Yi-Lei1; Wang, Yu-Hui2; Huang, Wei2; Liu, George2; Ross, Colin3; Hayden, Michael R.3; Yang, Jin-Kui1
关键词lipoprotein lipase glucose homeostasis insulin secretion
刊名EXPERIMENTAL BIOLOGY AND MEDICINE
2010
DOI10.1258/ebm.2009.009100
235期:1页:40-46
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
资助者National Natural Science Foundation of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; National Basic Research Program of China
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]LIPASE-DEFICIENT MICE ; CORONARY HEART-DISEASE ; II DIABETES-MELLITUS ; RESISTANCE ; ATHEROSCLEROSIS ; GENE ; METABOLISM ; EXPRESSION ; SECRETION ; LEVEL
英文摘要

Hypertriglyceridemia (HTG) is one of the key features of dyslipidemia in type 2 diabetes, caused by the overproduction and/or decreased clearance of triglyceride (TG)-rich lipoproteins, and significantly promotes the development of cardiovascular diseases in diabetes. However, the effect of severe HTG on glucose metabolism has not previously been determined. Lipoprotein lipase (LPL) deficiency results in severe HTG in humans. By using LPL-deficient mice with severe HTG, we assessed the impact of severe HTG on insulin secretion and glucose tolerance in the present study. While young LPL-deficient mice (4 months of age) showed higher fasting blood glucose (7.42 +/- 0.84 versus 4.8 +/- 0.80 mmol/L, P < 0.01) and lower insulin concentrations (0.16 +/- 0.03 versus 0.48 +/- 0.14 ng/mL, P < 0.05), old mice (112 months of age) had higher insulin (1.70 +/- 0.35 versus 0.77 +/- 0.04 ng/mL, P < 0.05) but normal fasting blood glucose concentrations. Both young and old mice had elevated free fatty acid (FFA) concentrations and exhibited decreased early insulin response; however, only old mice showed impaired glucose tolerance, as compared with wild-type mice of a similar age. Morphological assessment showed enlarged islets in old LPL-deficient mice. These findings suggest that different tests for glucose homeostasis may be needed for patients with LPL deficiency and severe HTG, even though their glucose concentrations are normal at initial screening.

语种英语
所属项目编号30671001 ; 30871187 ; 2006CB503909
资助者National Natural Science Foundation of China ; National Basic Research Program of China ; National Natural Science Foundation of China ; National Basic Research Program of China
WOS记录号WOS:000274538200007
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68172
专题北京大学基础医学院_心血管所
作者单位1.Capital Med Univ, Beijing Tongren Hosp, Dept Endocrinol, Beijing 100730, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100083, Peoples R China
3.Univ British Columbia, Ctr Mol Med & Therapeut, Dept Med Genet, Vancouver, BC V5Z 4H4, Canada
推荐引用方式
GB/T 7714
Ding, Yi-Lei,Wang, Yu-Hui,Huang, Wei,et al. Glucose intolerance and decreased early insulin response in mice with severe hypertriglyceridemia[J]. EXPERIMENTAL BIOLOGY AND MEDICINE,2010,235(1):40-46.
APA Ding, Yi-Lei.,Wang, Yu-Hui.,Huang, Wei.,Liu, George.,Ross, Colin.,...&Yang, Jin-Kui.(2010).Glucose intolerance and decreased early insulin response in mice with severe hypertriglyceridemia.EXPERIMENTAL BIOLOGY AND MEDICINE,235(1),40-46.
MLA Ding, Yi-Lei,et al."Glucose intolerance and decreased early insulin response in mice with severe hypertriglyceridemia".EXPERIMENTAL BIOLOGY AND MEDICINE 235.1(2010):40-46.
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