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Acute toxicity of nano- and micro-scale zinc powder in healthy adult mice
Wang, B; Feng, WY; Wang, TC; Guang, J; Wang, M; Shi, JW; Zhang, F; Zhao, YL; Chai, ZF
关键词acute toxicity nanoscale zinc powder microscale zinc powder mice
刊名TOXICOLOGY LETTERS
2006-02-20
DOI10.1016/j.toxlet.2005.08.007
161期:2页:115-123
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Toxicology
研究领域[WOS]Toxicology
关键词[WOS]INDUCED HEMOLYTIC-ANEMIA ; ULTRAFINE PARTICLES ; LUNG INJURY ; RATS ; RESPONSES ; EXPOSURE ; TISSUES
英文摘要

The purpose of this study is to evaluate the acute toxicity of oral exposure to nanoscale zinc powder in mice. The healthy adult male and female mice were gastrointestinally administered at a dose of 5 g/kg body weight with two size particles, nanoscale zinc (N-Zn) and microscale zinc (M-Zn) powder, while one group mice treated with sodium carboxy methyl cellulose was used as the control. The symptoms and mortality after zinc powder treatment were recorded. The effects of particles on the blood-element, the serum biochemical level and the blood coagulation were studied after 2 weeks of administration. The organs were collected for histopathological examination. The N-Zn treated mice showed more severe symptoms of lethargy, vomiting and diarrhea in the beginning days than the M-Zn mice. Deaths of two mice occurred in the N-Zn group after the first week of treatment. The mortalities were confirmed by intestinal obstruction of the nanoscale zinc aggregation. The biochemical liver function tests of serum showed significantly elevated ALT, AST, ALP, and LDH in the M-Zn mice and ALT, ALP, and LDH in the N-Zn mice compared with the controls (P < 0.05), which indicated that the liver damage was probably induced by both micro- and nano-scale zinc powders. The clinical changes were observed in the two treated group mice as well. The levels of the above enzymes were generally higher in the M-Zn mice than in the N-Zn mice, which implied that M-Zn powder could induce more severe liver damage than N-Zn. The biochemical renal function tests of serum BUN and CR in the M-Zn mice markedly increased either compared with the N-Zn mice or with the controls (P < 0.05), but no significant difference was found between the N-Zn and the control mice. However, severe renal lesions were found by the renal histopathological examination in the N-Zn exposed mice. Therefore, we concluded that severe renal damage could occur in the N-Zn treated mice, though no significant change of blood biochemical levels occurred. Blood-element test showed that in the N-Zn mice, PLT and RDW-CV significantly increased, and HGB and HCT significantly decreased compared to the controls, which indicated that N-Zn powder could cause severe anemia. Besides the pathological lesions in the liver, renal, and heart tissue, only slight stomach and intestinal inflammation was found in all the zinc treated mice, without significant pathological changes in other organs. (c) 2005 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000234839400005
引用统计
被引频次:176[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68173
专题北京大学第三临床医学院
作者单位1.Chinese Acad Sci, Lab Bioenvironm Hlth Sci Nanoscale Mat, Beijing 100049, Peoples R China
2.Chinese Acad Sci, Inst High Energy Phys, Key Lab Nucl Analyt Tech, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
4.Peking Univ, Hosp 3, Dept Clin Lab Med, Beijing 100083, Peoples R China
5.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, B,Feng, WY,Wang, TC,et al. Acute toxicity of nano- and micro-scale zinc powder in healthy adult mice[J]. TOXICOLOGY LETTERS,2006,161(2):115-123.
APA Wang, B.,Feng, WY.,Wang, TC.,Guang, J.,Wang, M.,...&Chai, ZF.(2006).Acute toxicity of nano- and micro-scale zinc powder in healthy adult mice.TOXICOLOGY LETTERS,161(2),115-123.
MLA Wang, B,et al."Acute toxicity of nano- and micro-scale zinc powder in healthy adult mice".TOXICOLOGY LETTERS 161.2(2006):115-123.
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