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学科主题药学
PEG-PLA diblock copolymer micelle-like nanoparticles as all-trans-retinoic acid carrier: in vitro and in vivo characterizations
Li, Yuan1; Qi, Xian Rong1; Maitani, Yoshie2; Nagai, Tsuneji3
刊名NANOTECHNOLOGY
2009-02-04
DOI10.1088/0957-4484/20/5/055106
20期:5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
资助者National Basic Research Program of China ; National Natural Science Foundation ; National Basic Research Program of China ; National Natural Science Foundation
研究领域[WOS]Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]POLYMERIC MICELLES ; BLOCK-COPOLYMER ; POLY(ETHYLENE GLYCOL) ; TRIBLOCK COPOLYMERS ; DRUG-DELIVERY ; RELEASE ; BIODISTRIBUTION ; DOXORUBICIN ; WATER ; ATRA
英文摘要

The purpose of this study was to characterize the properties in vitro, i.e. release, degradation, hemolytic potential and anticancer activity, and in vivo disposition of all-trans-retinoic acid (ATRA) in rats after administration of ATRA-loaded micelle-like nanoparticles. The amphiphilic block copolymers consisted of a micellar shell-forming mPEG block and a core-forming PLA block. The mPEG-PLA nanoparticles prepared by an acetone volatilization dialysis procedure were identified as having core-shell structure by H-1 NMR spectroscopy. Critical association concentration, drug contents, loading efficiency, particle size and xi potential were evaluated. The release of ATRA from the nanoparticles and the degradation of PLA were found to be mostly associated with the compositions of the nanoparticles. ATRA release was faster at smaller molecular weight of copolymer and lower drug contents. In vitro, the incorporation of ATRA in mPEG-PLA nanoparticles reduced the hemolytic potential of ATRA. Furthermore, anticancer activity of ATRA against HepG2 cell was increased by encapsulation, which showed an enhancement of tumor treatment of ATRA. In vivo, after intravenous injection to rats, the levels of ATRA in the blood stream and the bioavailability were higher for ATRA-loaded mPEG-PLA nanoparticles than those for ATRA solution. In conclusion, the structure of the mPEG-PLA diblock copolymer could be modulated to fit the demand of in vitro and in vivo characterizations of nanoparticles. The mPEG-PLA nanoparticles′ loading ATRA have a promising future for injection administration.

语种英语
所属项目编号2007CB935801 ; 30772665
资助者National Basic Research Program of China ; National Natural Science Foundation ; National Basic Research Program of China ; National Natural Science Foundation
WOS记录号WOS:000262375700006
Citation statistics
Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68176
Collection北京大学药学院_药剂学系
作者单位1.Hoshi Univ, Inst Med Chem, Shinagawa Ku, Tokyo 1428501, Japan
2.Nagai Fdn Tokyo, Bunkyo Ku, Tokyo 1130021, Japan
3.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Li, Yuan,Qi, Xian Rong,Maitani, Yoshie,et al. PEG-PLA diblock copolymer micelle-like nanoparticles as all-trans-retinoic acid carrier: in vitro and in vivo characterizations[J]. NANOTECHNOLOGY,2009,20(5).
APA Li, Yuan,Qi, Xian Rong,Maitani, Yoshie,&Nagai, Tsuneji.(2009).PEG-PLA diblock copolymer micelle-like nanoparticles as all-trans-retinoic acid carrier: in vitro and in vivo characterizations.NANOTECHNOLOGY,20(5).
MLA Li, Yuan,et al."PEG-PLA diblock copolymer micelle-like nanoparticles as all-trans-retinoic acid carrier: in vitro and in vivo characterizations".NANOTECHNOLOGY 20.5(2009).
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