IR@PKUHSC  > 北京大学药学院  > 药剂学系
学科主题药学
PEG-PLA diblock copolymer micelle-like nanoparticles as all-trans-retinoic acid carrier: in vitro and in vivo characterizations
Li, Yuan1; Qi, Xian Rong1; Maitani, Yoshie2; Nagai, Tsuneji3
刊名NANOTECHNOLOGY
2009-02-04
DOI10.1088/0957-4484/20/5/055106
20期:5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]POLYMERIC MICELLES ; BLOCK-COPOLYMER ; POLY(ETHYLENE GLYCOL) ; TRIBLOCK COPOLYMERS ; DRUG-DELIVERY ; RELEASE ; BIODISTRIBUTION ; DOXORUBICIN ; WATER ; ATRA
英文摘要

The purpose of this study was to characterize the properties in vitro, i.e. release, degradation, hemolytic potential and anticancer activity, and in vivo disposition of all-trans-retinoic acid (ATRA) in rats after administration of ATRA-loaded micelle-like nanoparticles. The amphiphilic block copolymers consisted of a micellar shell-forming mPEG block and a core-forming PLA block. The mPEG-PLA nanoparticles prepared by an acetone volatilization dialysis procedure were identified as having core-shell structure by H-1 NMR spectroscopy. Critical association concentration, drug contents, loading efficiency, particle size and xi potential were evaluated. The release of ATRA from the nanoparticles and the degradation of PLA were found to be mostly associated with the compositions of the nanoparticles. ATRA release was faster at smaller molecular weight of copolymer and lower drug contents. In vitro, the incorporation of ATRA in mPEG-PLA nanoparticles reduced the hemolytic potential of ATRA. Furthermore, anticancer activity of ATRA against HepG2 cell was increased by encapsulation, which showed an enhancement of tumor treatment of ATRA. In vivo, after intravenous injection to rats, the levels of ATRA in the blood stream and the bioavailability were higher for ATRA-loaded mPEG-PLA nanoparticles than those for ATRA solution. In conclusion, the structure of the mPEG-PLA diblock copolymer could be modulated to fit the demand of in vitro and in vivo characterizations of nanoparticles. The mPEG-PLA nanoparticles′ loading ATRA have a promising future for injection administration.

语种英语
WOS记录号WOS:000262375700006
项目编号2007CB935801 ; 30772665
资助机构National Basic Research Program of China ; National Natural Science Foundation
引用统计
被引频次:41[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68176
专题北京大学药学院_药剂学系
作者单位1.Hoshi Univ, Inst Med Chem, Shinagawa Ku, Tokyo 1428501, Japan
2.Nagai Fdn Tokyo, Bunkyo Ku, Tokyo 1130021, Japan
3.Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Yuan,Qi, Xian Rong,Maitani, Yoshie,et al. PEG-PLA diblock copolymer micelle-like nanoparticles as all-trans-retinoic acid carrier: in vitro and in vivo characterizations[J]. NANOTECHNOLOGY,2009,20(5).
APA Li, Yuan,Qi, Xian Rong,Maitani, Yoshie,&Nagai, Tsuneji.(2009).PEG-PLA diblock copolymer micelle-like nanoparticles as all-trans-retinoic acid carrier: in vitro and in vivo characterizations.NANOTECHNOLOGY,20(5).
MLA Li, Yuan,et al."PEG-PLA diblock copolymer micelle-like nanoparticles as all-trans-retinoic acid carrier: in vitro and in vivo characterizations".NANOTECHNOLOGY 20.5(2009).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Yuan]的文章
[Qi, Xian Rong]的文章
[Maitani, Yoshie]的文章
百度学术
百度学术中相似的文章
[Li, Yuan]的文章
[Qi, Xian Rong]的文章
[Maitani, Yoshie]的文章
必应学术
必应学术中相似的文章
[Li, Yuan]的文章
[Qi, Xian Rong]的文章
[Maitani, Yoshie]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。