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学科主题: 基础医学
题名:
Identification and Characterization of the First Escherichia coli Strain Carrying NDM-1 Gene in China
作者: Liu, Zhiyuan1,2; Li, Wei3; Wang, Jie1; Pan, Jian1; Sun, Shipeng1; Yu, Yanhua4; Zhao, Bing1; Ma, Yuzhi1; Zhang, Tingju1; Qi, Jie1; Liu, Guijian1; Lu, Fengmin2
刊名: PLOS ONE
发表日期: 2013-06-10
DOI: 10.1371/journal.pone.0066666
卷: 8, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: METALLO-BETA-LACTAMASE ; ACINETOBACTER-BAUMANNII ; ENTEROBACTERIACEAE ; EMERGENCE ; RESISTANCE ; CARBAPENEMASES ; DISSEMINATION ; WORLDWIDE ; INFECTION ; PLASMID
英文摘要:

New Delhi metallo-beta-lactamase-1 (NDM-1), an acquired class B carbapenemase, is a significant clinical threat due to its extended hydrolysis of beta-lactams including carbapenems. In this study, we identified the first confirmed clinical isolate of Escherichia coli BJ01 harboring bla(NDM-1) in China. The isolate is highly resistant to all tested antimicrobials except polymyxin. bla(NDM-1), bla(CTX-M-57), and bla(TEM-1) were identified in the isolate. bla(NDM-1) was transferable to E. coli EC600 and DH5 alpha in both plasmid conjugation experiments and plasmid transformation tests. BJ01 was identified as a new sequence type, ST224, by multilocus sequence typing. Analysis of genetic environment shows complex transposon-like structures surrounding the blaNDM-1 gene. Genetic analysis revealed that the region flanking blaNDM-1 was very similar to previously identified NDM-positive Acinetobacter spp. isolated in China. The findings of this study raise attention to the emergence and spread of NDM-1-carrying Enterobacteriaceae in China.

语种: 英语
所属项目编号: 2011S242 ; JYAN-2011-064
项目资助者: Guang&prime ; anmen Hospital ; Beijing You&prime ; an Project for Liver diseases and AIDS
WOS记录号: WOS:000320440500069
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68182
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Ctr Infect Dis, Beijing 100871, Peoples R China
3.Capital Med Univ, Beijing Youan Hosp, Ctr Infect Dis, Beijing, Peoples R China
4.Capital Med Univ, Beijing Youan Hosp, Dept Clin Lab, Beijing, Peoples R China

Recommended Citation:
Liu, Zhiyuan,Li, Wei,Wang, Jie,et al. Identification and Characterization of the First Escherichia coli Strain Carrying NDM-1 Gene in China[J]. PLOS ONE,2013,8(6).
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