IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Identification and Characterization of the First Escherichia coli Strain Carrying NDM-1 Gene in China
Liu, Zhiyuan1,2; Li, Wei3; Wang, Jie1; Pan, Jian1; Sun, Shipeng1; Yu, Yanhua4; Zhao, Bing1; Ma, Yuzhi1; Zhang, Tingju1; Qi, Jie1; Liu, Guijian1; Lu, Fengmin2
刊名PLOS ONE
2013-06-10
DOI10.1371/journal.pone.0066666
8期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者Guang&prime ; anmen Hospital ; Beijing You&prime ; an Project for Liver diseases and AIDS ; Guang&prime ; anmen Hospital ; Beijing You&prime ; an Project for Liver diseases and AIDS
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]METALLO-BETA-LACTAMASE ; ACINETOBACTER-BAUMANNII ; ENTEROBACTERIACEAE ; EMERGENCE ; RESISTANCE ; CARBAPENEMASES ; DISSEMINATION ; WORLDWIDE ; INFECTION ; PLASMID
英文摘要

New Delhi metallo-beta-lactamase-1 (NDM-1), an acquired class B carbapenemase, is a significant clinical threat due to its extended hydrolysis of beta-lactams including carbapenems. In this study, we identified the first confirmed clinical isolate of Escherichia coli BJ01 harboring bla(NDM-1) in China. The isolate is highly resistant to all tested antimicrobials except polymyxin. bla(NDM-1), bla(CTX-M-57), and bla(TEM-1) were identified in the isolate. bla(NDM-1) was transferable to E. coli EC600 and DH5 alpha in both plasmid conjugation experiments and plasmid transformation tests. BJ01 was identified as a new sequence type, ST224, by multilocus sequence typing. Analysis of genetic environment shows complex transposon-like structures surrounding the blaNDM-1 gene. Genetic analysis revealed that the region flanking blaNDM-1 was very similar to previously identified NDM-positive Acinetobacter spp. isolated in China. The findings of this study raise attention to the emergence and spread of NDM-1-carrying Enterobacteriaceae in China.

语种英语
所属项目编号2011S242 ; JYAN-2011-064
资助者Guang&prime ; anmen Hospital ; Beijing You&prime ; an Project for Liver diseases and AIDS ; Guang&prime ; anmen Hospital ; Beijing You&prime ; an Project for Liver diseases and AIDS
WOS记录号WOS:000320440500069
Citation statistics
Cited Times:67[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68182
Collection北京大学基础医学院_病原生物学系
作者单位1.China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Ctr Infect Dis, Beijing 100871, Peoples R China
3.Capital Med Univ, Beijing Youan Hosp, Ctr Infect Dis, Beijing, Peoples R China
4.Capital Med Univ, Beijing Youan Hosp, Dept Clin Lab, Beijing, Peoples R China
Recommended Citation
GB/T 7714
Liu, Zhiyuan,Li, Wei,Wang, Jie,et al. Identification and Characterization of the First Escherichia coli Strain Carrying NDM-1 Gene in China[J]. PLOS ONE,2013,8(6).
APA Liu, Zhiyuan.,Li, Wei.,Wang, Jie.,Pan, Jian.,Sun, Shipeng.,...&Lu, Fengmin.(2013).Identification and Characterization of the First Escherichia coli Strain Carrying NDM-1 Gene in China.PLOS ONE,8(6).
MLA Liu, Zhiyuan,et al."Identification and Characterization of the First Escherichia coli Strain Carrying NDM-1 Gene in China".PLOS ONE 8.6(2013).
Files in This Item: Download All
File Name/Size DocType Version Access License
Identification and C(1052KB)期刊论文出版稿开放获取CC BY-NC-SAView Download
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Liu, Zhiyuan]'s Articles
[Li, Wei]'s Articles
[Wang, Jie]'s Articles
百度学术
百度学术Similar articles in
[Liu, Zhiyuan]'s Articles
[Li, Wei]'s Articles
[Wang, Jie]'s Articles
必应学术
必应学术Similar articles in
[Liu, Zhiyuan]'s Articles
[Li, Wei]'s Articles
[Wang, Jie]'s Articles
Terms of Use
No data!
Social Bookmark/Share
File name: Identification and Characterization of the First Escherichia coli Strain Carrying NDM-1 Gene in China.pdf
Format: Adobe PDF
This file does not support browsing at this time
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.