IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Identification and Characterization of the First Escherichia coli Strain Carrying NDM-1 Gene in China
Liu, Zhiyuan1,2; Li, Wei3; Wang, Jie1; Pan, Jian1; Sun, Shipeng1; Yu, Yanhua4; Zhao, Bing1; Ma, Yuzhi1; Zhang, Tingju1; Qi, Jie1; Liu, Guijian1; Lu, Fengmin2
刊名PLOS ONE
2013-06-10
DOI10.1371/journal.pone.0066666
8期:6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]METALLO-BETA-LACTAMASE ; ACINETOBACTER-BAUMANNII ; ENTEROBACTERIACEAE ; EMERGENCE ; RESISTANCE ; CARBAPENEMASES ; DISSEMINATION ; WORLDWIDE ; INFECTION ; PLASMID
英文摘要

New Delhi metallo-beta-lactamase-1 (NDM-1), an acquired class B carbapenemase, is a significant clinical threat due to its extended hydrolysis of beta-lactams including carbapenems. In this study, we identified the first confirmed clinical isolate of Escherichia coli BJ01 harboring bla(NDM-1) in China. The isolate is highly resistant to all tested antimicrobials except polymyxin. bla(NDM-1), bla(CTX-M-57), and bla(TEM-1) were identified in the isolate. bla(NDM-1) was transferable to E. coli EC600 and DH5 alpha in both plasmid conjugation experiments and plasmid transformation tests. BJ01 was identified as a new sequence type, ST224, by multilocus sequence typing. Analysis of genetic environment shows complex transposon-like structures surrounding the blaNDM-1 gene. Genetic analysis revealed that the region flanking blaNDM-1 was very similar to previously identified NDM-positive Acinetobacter spp. isolated in China. The findings of this study raise attention to the emergence and spread of NDM-1-carrying Enterobacteriaceae in China.

语种英语
WOS记录号WOS:000320440500069
项目编号2011S242 ; JYAN-2011-064
资助机构Guang&prime ; anmen Hospital ; Beijing You&prime ; an Project for Liver diseases and AIDS
引用统计
被引频次:128[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68182
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Ctr Infect Dis, Beijing 100871, Peoples R China
3.Capital Med Univ, Beijing Youan Hosp, Ctr Infect Dis, Beijing, Peoples R China
4.Capital Med Univ, Beijing Youan Hosp, Dept Clin Lab, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Liu, Zhiyuan,Li, Wei,Wang, Jie,et al. Identification and Characterization of the First Escherichia coli Strain Carrying NDM-1 Gene in China[J]. PLOS ONE,2013,8(6).
APA Liu, Zhiyuan.,Li, Wei.,Wang, Jie.,Pan, Jian.,Sun, Shipeng.,...&Lu, Fengmin.(2013).Identification and Characterization of the First Escherichia coli Strain Carrying NDM-1 Gene in China.PLOS ONE,8(6).
MLA Liu, Zhiyuan,et al."Identification and Characterization of the First Escherichia coli Strain Carrying NDM-1 Gene in China".PLOS ONE 8.6(2013).
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