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Alleviation of Hyperglycemia Induced Vascular Endothelial Injury by Exenatide Might Be Related to the Reduction of Nitrooxidative Stress
Zhao, Qian1,2; Xu, Chun-ling3; Xiong, Hai-yan1; Huang, Wen4; Zhang, Mei4; Wang, Yun5; Wang, Si-yu4; Wang, Wen1
刊名BIOMED RESEARCH INTERNATIONAL
2013
DOI10.1155/2013/843657
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]GLUCAGON-LIKE PEPTIDE-1 ; TYPE-2 DIABETES-MELLITUS ; INSULIN-RESISTANCE ; ISCHEMIA/REPERFUSION INJURY ; DIPEPTIDYL PEPTIDASE-4 ; DYSFUNCTION ; RECEPTOR ; GLP-1 ; RATS ; GLUCOSE
英文摘要

We will investigate the effects of exenatide on vascular endothelial injury and nitrooxidative stress in hyperglycemia both in vivo and in vitro and explore the role of nitrooxidative stress in endothelium-protective action of exenatide. Healthy male Wistar rats were randomly divided into 4 groups: control, diabetes mellitus (DM) model, low dose of exenatide treatment, and high dose of exenatide treatment. In vitro study showed that, compared with control group, the DM rats exhibited a lowered endothelium-dependent relaxation and damaged structural integrity of thoracic aortas, and there was a significant increase in plasma nitrotyrosine concentration. These parameters were improved after treatment with either low dose or high dose of exenatide for 45 days. In vitro study showed that exendin-4 (the active ingredient of exenatide) attenuated HUVECs injury induced by high glucose, with improving cell viability and attenuating cell apoptosis. Exendin-4 also significantly alleviated the increased malondialdehyde (MDA), nitrotyrosine content, and inducible nitric oxide synthase (iNOS) expression induced by high glucose in HUVECs. In conclusion, this study demonstrates that exenatide treatment can alleviate the vascular endothelial injury, as well as attenuating the nitrooxidative stress in hyperglycemia, implying that the endothelium-protective effect of exenatide might be related to the reduction of nitrooxidative stress.

语种英语
WOS记录号WOS:000327964600001
项目编号CITTCD201304190 ; 11JL41 ; 12JL49 ; 2010-04
资助机构Importation and Development of High-Caliber Talents Project of Beijing Municipal Institutions ; Basic Clinical Cooperation Foundation of Capital Medical University ; Scientific Research Foundation of Beijing Friendship Hospital
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68183
专题北京大学首钢医院
作者单位1.Capital Med Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100069, Peoples R China
2.Peking Univ, Shougang Hosp, Dept Nursing, Beijing 100144, Peoples R China
3.Capital Med Univ, Beijing Friendship Hosp, Dept Neurol, Beijing 100050, Peoples R China
4.Capital Med Univ, Beijing Tongren Hosp, Dept Nephrol, Beijing 100730, Peoples R China
5.Capital Med Univ, Beijing Tongren Hosp, Dept Geriatr, Beijing 100730, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Qian,Xu, Chun-ling,Xiong, Hai-yan,et al. Alleviation of Hyperglycemia Induced Vascular Endothelial Injury by Exenatide Might Be Related to the Reduction of Nitrooxidative Stress[J]. BIOMED RESEARCH INTERNATIONAL,2013.
APA Zhao, Qian.,Xu, Chun-ling.,Xiong, Hai-yan.,Huang, Wen.,Zhang, Mei.,...&Wang, Wen.(2013).Alleviation of Hyperglycemia Induced Vascular Endothelial Injury by Exenatide Might Be Related to the Reduction of Nitrooxidative Stress.BIOMED RESEARCH INTERNATIONAL.
MLA Zhao, Qian,et al."Alleviation of Hyperglycemia Induced Vascular Endothelial Injury by Exenatide Might Be Related to the Reduction of Nitrooxidative Stress".BIOMED RESEARCH INTERNATIONAL (2013).
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