北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 胃肠肿瘤中心  > 期刊论文
学科主题: 临床医学
题名:
Hyperthermic Intraperitoneal Chemotherapy Plus Simultaneous Versus Staged Cytoreductive Surgery for Gastric Cancer With Occult Peritoneal Metastasis
作者: Wu, Xiaojiang; Li, Ziyu; Li, Ziran; Jia, Yongning; Shan, Fei; Ji, Xin; Bu, Zhaode; Zhang, Lianhai; Wu, Aiwen; Ji, Jiafu
关键词: gastric cancer ; occult peritoneal metastasis ; diagnostic laparoscopy ; hyperthermic intraperitoneal chemotherapy ; cytoreductive surgery
刊名: JOURNAL OF SURGICAL ONCOLOGY
发表日期: 2015-06-01
DOI: 10.1002/jso.23889
卷: 111, 期:7, 页:840-847
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Surgery
研究领域[WOS]: Oncology ; Surgery
关键词[WOS]: ADVANCED ESOPHAGOGASTRIC CANCER ; 1ST-LINE THERAPY ; PHASE-III ; CARCINOMATOSIS ; OXALIPLATIN ; TUMORS ; TRIAL ; S-1 ; ADENOCARCINOMA ; FLUOROURACIL
英文摘要:

BackgroundOur aim is to evaluate the safety and efficacy of two treatment strategies, hyperthermic intraperitoneal chemotherapy (HIPEC) plus simultaneous versus staged cytoreductive surgery (CRS) in patients with occult peritoneal metastasis of gastric cancer (GC).

MethodsWe retrospectively reviewed 26 GC patients who were potential curatively resectable by pre-operative evaluation and found occult peritoneal metastasis by diagnostic laparoscopy. Patients were treated by HIPEC plus either simultaneous CRS (CRS+HIPEC group, n=11) or staged CRS after systematic chemotherapy (HIPEC+Chemo+CRS group, n=15).

ResultsThere is no mortality observed in both groups. The treatment complications in two group is comparable (P=0.683), with 26.7% (4/15) in HIPEC+Chemo+CRS group, and 36.4% (4/11) in CRS+HIPEC group, respectively. The compliance of patients undergoing subsequent chemotherapy is higher in HIPEC+Chemo+CRS group (93.3%, 14/15) than that of CRS+HIPEC group (45.5%, 5/11) (P=0.021). The mean interval time between CRS and first post-CRS systematic chemotherapy were 42.012.0 days in HIPEC+Chemo+CRS group versus 69.8 +/- 36.3 in CRS+HIPEC group (P=0.163), respectively. The median OS in the HIPEC+Chemo+CRS group was 25.0 months, while 28.2 months in the CRS+HIPEC group (P=0.738).

ConclusionFor resectable GC patients with laparoscopic findings of occult peritoneal metastasis, HIPEC plus staged CRS is with better tolerance and compliance than simultaneous CRS. J. Surg. Oncol. 2015 111:840-847. (c) 2014 Wiley Periodicals, Inc.

语种: 英语
项目资助者: Open Fund of Key Laboratory of Carcinogenesis ; Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute
WOS记录号: WOS:000353996400009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68186
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Surg, Canc Hosp & Inst,Minist Educ, Beijing 100871, Peoples R China

Recommended Citation:
Wu, Xiaojiang,Li, Ziyu,Li, Ziran,et al. Hyperthermic Intraperitoneal Chemotherapy Plus Simultaneous Versus Staged Cytoreductive Surgery for Gastric Cancer With Occult Peritoneal Metastasis[J]. JOURNAL OF SURGICAL ONCOLOGY,2015,111(7):840-847.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Wu, Xiaojiang]'s Articles
[Li, Ziyu]'s Articles
[Li, Ziran]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Wu, Xiaojiang]‘s Articles
[Li, Ziyu]‘s Articles
[Li, Ziran]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace