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学科主题: 临床医学
题名:
Evaluation of primary malignancies of the liver using contrast-enhanced sonography: Correlation with pathology
作者: Fan, ZH; Chen, MH; Dai, Y; Wang, YB; Yan, K; Wu, W; Yang, W; Yin, SS
关键词: contrast agents ; primary malignancies of the liver ; sonography
刊名: AMERICAN JOURNAL OF ROENTGENOLOGY
发表日期: 2006-06-01
DOI: 10.2214/AJR.05.0943
卷: 186, 期:6, 页:1512-1519
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: SMALL HEPATOCELLULAR-CARCINOMA ; PERIPHERAL CHOLANGIOCARCINOMA ; CIRRHOTIC LIVERS ; KUPFFER CELLS ; LESIONS ; CT ; DIFFERENTIATION ; AGENT
英文摘要:

OBJECTIVE. Our purpose was to investigate the correlation of contrast-enhanced sonographic patterns with the histopathology of primary malignancies of the liver.

MATERIAL AND METHODS. Of the 318 contrast-enhanced sonographic examinations performed between April and September 2004, 95 patients with 117 lesions confirmed by surgery or biopsy pathology were reviewed in this study. We analyzed the enhancement time and patterns according to the types and degrees of pathologic differentiation.

RESULTS. All 65 moderately to poorly differentiated hepatocellular carcinomas (HCCs) enhanced in the arterial phase, and 96.9% (63 lesions) of them quickly washed out in the portal venous phase. All 32 well-differentiated HCCs enhanced in the arterial phase, and 50.0% (16 lesions) washed out slowly during the late phase. The washout time of the two differentiated types was significantly different (p < 0.05). Seventy-five percent of the clear cell carcinomas (12/16) enhanced in the arterial phase, 25% (4/16) did not enhance until the portal venous phase, and 31.3% (5/16) of the clear cell carcinomas washed out slowly during the late phase. The enhancement and washout times of clear cell carcinomas were significantly different than those of moderately to poorly differentiated HCCs (p < 0.05). All four intrahepatic cholangiocarcinomas presented the same patterns as moderately to poorly differentiated HCCs: enhanced in the arterial phase and quickly washed out in the portal venous phase. Among the 72 lesions enhanced homogeneously, 46 lesions (63.9%) were smaller than 3 cm. Thirty-seven lesions (82.2%) of the 45 lesions that enhanced heterogeneously were larger than 3 cm (including the four cholangiocarcinomas). Larger lesions were mainly less differentiated. There were significant differences in tumor sizes in regard to cellular differentiations and types.

CONCLUSION. Our study showed that the enhancement manifestations of primary malignancies of the liver are related to pathologic types and grades. Contrast-enhanced sonograms may provide the histopathologic information for malignant tumors of the liver.

语种: 英语
WOS记录号: WOS:000237759300007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68188
Appears in Collections:北京大学临床肿瘤学院_超声科_期刊论文

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作者单位: Peking Univ, Sch Oncol, Dept Ultrasound, Beijing 100036, Peoples R China

Recommended Citation:
Fan, ZH,Chen, MH,Dai, Y,et al. Evaluation of primary malignancies of the liver using contrast-enhanced sonography: Correlation with pathology[J]. AMERICAN JOURNAL OF ROENTGENOLOGY,2006,186(6):1512-1519.
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