IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Biomimetic remineralization of demineralized enamel with nano-complexes of phosphorylated chitosan and amorphous calcium phosphate
Zhang, Xu1; Li, Yanqiu1; Sun, Xiaoxi1; Kishen, Anil2; Deng, Xuliang3; Yang, Xiaoping4; Wang, Huajun5; Cong, Changhong1; Wang, Yinghui1; Wu, Mingyao1
刊名JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
2014-12-01
DOI10.1007/s10856-014-5285-2
25期:12页:2619-2628
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]CHITIN ; DENTIN ; MATRIX ; BIOMINERALIZATION ; HYDROXYAPATITE ; NANOPARTICLES ; BIOMATERIALS ; NUCLEATION ; APATITE ; LESIONS
英文摘要

Remineralization of enamel plays a crucial role in the progression of carious process and the management of early caries lesion. Based on the influence of phosphorylated proteins in biomineralization, the objective of this study was to synthesize nano-complexes of phosphorylated chitosan and amorphous calcium phosphate (Pchi-ACP), and evaluate their ability to remineralize enamel subsurface lesions in vitro. Pchi was synthesized using a previously established chemical method. The biomimetic remineralizing solution containing nano-complexes of Pchi-ACP was prepared by adding CaCl2 and K2HPO4 into Pchi-ACP solution (0.5 % w/v) in sequence. The final concentrations of calcium and phosphate ions were 10 and 6 mM, respectively. The nano-complexes of Pchi-ACP were characterized by Fourier-transform infrared (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), and selected area electron diffraction (SAED). During testing the enamel lesions were treated with Pchi-ACP and fluoridated remineralizing solutions, respectively. The remineralizing of enamel lesions was examined with field emission electron microscope (FE-SEM) and Micro-CT. ACP was stabilized by Pchi to form nano-complexes that were soluble in water. The size of Pchi-ACP nano-complexes particles was determined to be less than 50 nm. XRD and SAED results confirmed their amorphous phases. FE-SEM and Micro-CT results showed that the remineralizing effect of Pchi-ACP on enamel lesions was similar to that of fluoride. However, the remineralizing rate of Pchi-ACP treatment was significantly higher than that of fluoride treatment (P < 0.05). This study highlighted the potential of nanoparticles functionalized with a natural analogue involved in biomineralization, to remineralize early enamel caries.

语种英语
WOS记录号WOS:000345644300002
项目编号12JCQNJC09200 ; 81200817 ; 2012CB933900 ; 2012BAI07B00
资助机构Tianjin Research Program of Application Foundation and Advanced Technology (Youth Research Program) ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Science and Technology Support Project Foundation
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68189
专题北京大学口腔医学院
北京大学口腔医学院_特诊科
作者单位1.Tianjin Med Univ, Sch Dent, Hosp Stomatol, Tianjin 300070, Peoples R China
2.Univ Toronto, Fac Dent, Discipline Endodont, Toronto, ON, Canada
3.Peking Univ, Dept Geriatr Dent, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
4.Beijing Univ Chem Technol, Key Lab Beijing City Preparat & Proc Novel Polyme, Beijing 100029, Peoples R China
5.Hebei Univ Technol, Sch Energy & Environm Engn, Tianjin 300401, Peoples R China
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GB/T 7714
Zhang, Xu,Li, Yanqiu,Sun, Xiaoxi,et al. Biomimetic remineralization of demineralized enamel with nano-complexes of phosphorylated chitosan and amorphous calcium phosphate[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2014,25(12):2619-2628.
APA Zhang, Xu.,Li, Yanqiu.,Sun, Xiaoxi.,Kishen, Anil.,Deng, Xuliang.,...&Wu, Mingyao.(2014).Biomimetic remineralization of demineralized enamel with nano-complexes of phosphorylated chitosan and amorphous calcium phosphate.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,25(12),2619-2628.
MLA Zhang, Xu,et al."Biomimetic remineralization of demineralized enamel with nano-complexes of phosphorylated chitosan and amorphous calcium phosphate".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 25.12(2014):2619-2628.
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