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学科主题: 口腔医学
题名:
Biomimetic remineralization of demineralized enamel with nano-complexes of phosphorylated chitosan and amorphous calcium phosphate
作者: Zhang, Xu1; Li, Yanqiu1; Sun, Xiaoxi1; Kishen, Anil2; Deng, Xuliang3; Yang, Xiaoping4; Wang, Huajun5; Cong, Changhong1; Wang, Yinghui1; Wu, Mingyao1
刊名: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
发表日期: 2014-12-01
DOI: 10.1007/s10856-014-5285-2
卷: 25, 期:12, 页:2619-2628
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: CHITIN ; DENTIN ; MATRIX ; BIOMINERALIZATION ; HYDROXYAPATITE ; NANOPARTICLES ; BIOMATERIALS ; NUCLEATION ; APATITE ; LESIONS
英文摘要:

Remineralization of enamel plays a crucial role in the progression of carious process and the management of early caries lesion. Based on the influence of phosphorylated proteins in biomineralization, the objective of this study was to synthesize nano-complexes of phosphorylated chitosan and amorphous calcium phosphate (Pchi-ACP), and evaluate their ability to remineralize enamel subsurface lesions in vitro. Pchi was synthesized using a previously established chemical method. The biomimetic remineralizing solution containing nano-complexes of Pchi-ACP was prepared by adding CaCl2 and K2HPO4 into Pchi-ACP solution (0.5 % w/v) in sequence. The final concentrations of calcium and phosphate ions were 10 and 6 mM, respectively. The nano-complexes of Pchi-ACP were characterized by Fourier-transform infrared (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), and selected area electron diffraction (SAED). During testing the enamel lesions were treated with Pchi-ACP and fluoridated remineralizing solutions, respectively. The remineralizing of enamel lesions was examined with field emission electron microscope (FE-SEM) and Micro-CT. ACP was stabilized by Pchi to form nano-complexes that were soluble in water. The size of Pchi-ACP nano-complexes particles was determined to be less than 50 nm. XRD and SAED results confirmed their amorphous phases. FE-SEM and Micro-CT results showed that the remineralizing effect of Pchi-ACP on enamel lesions was similar to that of fluoride. However, the remineralizing rate of Pchi-ACP treatment was significantly higher than that of fluoride treatment (P < 0.05). This study highlighted the potential of nanoparticles functionalized with a natural analogue involved in biomineralization, to remineralize early enamel caries.

语种: 英语
所属项目编号: 12JCQNJC09200 ; 81200817 ; 2012CB933900 ; 2012BAI07B00
项目资助者: Tianjin Research Program of Application Foundation and Advanced Technology (Youth Research Program) ; National Natural Science Foundation of China ; National Basic Research Program of China ; National Science and Technology Support Project Foundation
WOS记录号: WOS:000345644300002
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68189
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Tianjin Med Univ, Sch Dent, Hosp Stomatol, Tianjin 300070, Peoples R China
2.Univ Toronto, Fac Dent, Discipline Endodont, Toronto, ON, Canada
3.Peking Univ, Dept Geriatr Dent, Sch & Hosp Stomatol, Beijing 100081, Peoples R China
4.Beijing Univ Chem Technol, Key Lab Beijing City Preparat & Proc Novel Polyme, Beijing 100029, Peoples R China
5.Hebei Univ Technol, Sch Energy & Environm Engn, Tianjin 300401, Peoples R China

Recommended Citation:
Zhang, Xu,Li, Yanqiu,Sun, Xiaoxi,et al. Biomimetic remineralization of demineralized enamel with nano-complexes of phosphorylated chitosan and amorphous calcium phosphate[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2014,25(12):2619-2628.
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