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学科主题: 药学
题名:
Simultaneous determination of six major stilbenes and flavonoids in Smilax china by high performance liquid chromatography
作者: Shao, Bo; Guo, Hong-zhu; Cui, Ya-jun; Liu, Ai-hua; Yu, Hal-lan; Guo, Hui; Xu, Man; Guo, De-an
关键词: Smilax china ; stilbenes ; flavonoids ; high performance liquid chromatography
刊名: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
发表日期: 2007-07-27
DOI: 10.1016/j.jpba.2007.03.008
卷: 44, 期:3, 页:737-742
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: CANCER CHEMOPREVENTIVE ACTIVITY ; ANTIOXIDANT ACTIVITY ; RESVERATROL ; CONSTITUENTS
英文摘要:

A simple, sensitive and specific HPLC method was developed for simultaneous determination of the six major active constituents in Smilax china, namely taxifolin-3-O-alycoside (1), piceid (2), oxyresveratrol (3), engeletin (4), resveratrol (5) and scirpusin A (6), respectively. The samples were separated on an Aglient Zorbax XDB-C-18 column with gradient elution of acetonitrile and 0.02% phosphoric acid (v/v) at a flow rate of 1.0 ml/min and detected at 300 nm. The six target compounds were completely separated within 35 min. All calibration Curves showed good linearity (r(2) > 0.999) within test ranges. The reproducibility was evaluated by intra- and inter-day assays and R.S.D. values were less than 3.7%. The recoveries were between 93.7 and 103.0%. The method was successfully applied to the analysis of six constituents in 15 commercial samples of S. china. The results indicated that the developed HPLC assay was readily utilized as a quality control method for S. china. (c) 2007 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000248738200015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68190
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Shao, Bo,Guo, Hong-zhu,Cui, Ya-jun,et al. Simultaneous determination of six major stilbenes and flavonoids in Smilax china by high performance liquid chromatography[J]. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,2007,44(3):737-742.
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