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Effects of Hedysari Polysaccharides on Regeneration and Function Recovery Following Peripheral Nerve Injury in Rats
Wei, Shao-Yin; Zhang, Pei-Xun; Han, Na; Dang, Yu; Zhang, Hong-Bo; Zhang, Dian-Ying; Fu, Zhong-Guo; Jiang, Bao-Guo
关键词Hedysari Polysaccharides Nerve Regeneration Motor Function Recovery Peripheral Nerve Injury
刊名AMERICAN JOURNAL OF CHINESE MEDICINE
2009
37期:1页:57-67
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine ; Medicine, General & Internal
研究领域[WOS]Integrative & Complementary Medicine ; General & Internal Medicine
英文摘要

It has been demonstrated that aqueous extract of Radix Hedysari Prescription and modified Radix Hedysari Prescription could improve the regeneration of injured peripheral nerve. Radix Hedysari is a main component in these two formulas. We hypothesized that Hedysari polysaccharides (HPS), a main active ingredient, could also enhance peripheral nerve regeneration after nerve injury in adult animals. In the present study, we examined the effects of HPS on sciatic nerve regeneration for 6 weeks following clamping in rats (administrated orally of 2 ml HPS liquid daily, 0.25 g/ml). The results showed that HPS was able to enhance sciatic function index (SFI) value, tibial function index (TFI) value, peroneal nerve function index (PFI) value, conduction velocity, and the number of regenerated myelinated nerve fibers, suggesting the potential clinical application of HPS for the treatment of peripheral nerve injury in humans.

语种英语
WOS记录号WOS:000263679300006
项目编号2003CB515306 ; 30625036
资助机构Chinese National 973 Project ; Chinese National Natural Science Fund for the Outstanding Youth
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68203
专题北京大学第二临床医学院
北京大学第二临床医学院_创伤骨科
北京大学第二临床医学院_党委院长办公室
作者单位Peking Univ, Peoples Hosp, Dept Orthopaed & Trauma, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Wei, Shao-Yin,Zhang, Pei-Xun,Han, Na,et al. Effects of Hedysari Polysaccharides on Regeneration and Function Recovery Following Peripheral Nerve Injury in Rats[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2009,37(1):57-67.
APA Wei, Shao-Yin.,Zhang, Pei-Xun.,Han, Na.,Dang, Yu.,Zhang, Hong-Bo.,...&Jiang, Bao-Guo.(2009).Effects of Hedysari Polysaccharides on Regeneration and Function Recovery Following Peripheral Nerve Injury in Rats.AMERICAN JOURNAL OF CHINESE MEDICINE,37(1),57-67.
MLA Wei, Shao-Yin,et al."Effects of Hedysari Polysaccharides on Regeneration and Function Recovery Following Peripheral Nerve Injury in Rats".AMERICAN JOURNAL OF CHINESE MEDICINE 37.1(2009):57-67.
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