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学科主题: 临床医学
题名:
Effects of Hedysari Polysaccharides on Regeneration and Function Recovery Following Peripheral Nerve Injury in Rats
作者: Wei, Shao-Yin; Zhang, Pei-Xun; Han, Na; Dang, Yu; Zhang, Hong-Bo; Zhang, Dian-Ying; Fu, Zhong-Guo; Jiang, Bao-Guo
关键词: Hedysari Polysaccharides ; Nerve Regeneration ; Motor Function Recovery ; Peripheral Nerve Injury
刊名: AMERICAN JOURNAL OF CHINESE MEDICINE
发表日期: 2009
卷: 37, 期:1, 页:57-67
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine ; Medicine, General & Internal
研究领域[WOS]: Integrative & Complementary Medicine ; General & Internal Medicine
英文摘要:

It has been demonstrated that aqueous extract of Radix Hedysari Prescription and modified Radix Hedysari Prescription could improve the regeneration of injured peripheral nerve. Radix Hedysari is a main component in these two formulas. We hypothesized that Hedysari polysaccharides (HPS), a main active ingredient, could also enhance peripheral nerve regeneration after nerve injury in adult animals. In the present study, we examined the effects of HPS on sciatic nerve regeneration for 6 weeks following clamping in rats (administrated orally of 2 ml HPS liquid daily, 0.25 g/ml). The results showed that HPS was able to enhance sciatic function index (SFI) value, tibial function index (TFI) value, peroneal nerve function index (PFI) value, conduction velocity, and the number of regenerated myelinated nerve fibers, suggesting the potential clinical application of HPS for the treatment of peripheral nerve injury in humans.

语种: 英语
所属项目编号: 2003CB515306 ; 30625036
项目资助者: Chinese National 973 Project ; Chinese National Natural Science Fund for the Outstanding Youth
WOS记录号: WOS:000263679300006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68203
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Orthopaed & Trauma, Beijing 100044, Peoples R China

Recommended Citation:
Wei, Shao-Yin,Zhang, Pei-Xun,Han, Na,et al. Effects of Hedysari Polysaccharides on Regeneration and Function Recovery Following Peripheral Nerve Injury in Rats[J]. AMERICAN JOURNAL OF CHINESE MEDICINE,2009,37(1):57-67.
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