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学科主题: 临床医学
题名:
A 10 year surveillance for antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae in community- and hospital-associated intra-abdominal infections in China
作者: Yang, Qiwen1; Zhang, Hui1; Wang, Yao1; Xu, Yingchun1; Chen, Minjun1; Badal, Robert E.2; Wang, Hui3; Ni, Yuxing4; Yu, Yunsong5; Hu, Bijie6; Sun, Ziyong7; Huang, Wenxiang8; Wang, Yong9; Wu, Anhua10; Feng, Xianju11; Liao, Kang12; Shen, Dingxia13; Hu, Zhidong14; Chu, Yunzhuo15; Lu, Juan16; Cao, Bin17; Su, Jianrong18; Gui, Bingdong19; Duan, Qiong; Zhang, Shufang20; Shao, Haifeng21; Kong, Haishen22; Hu, Yunjian23; Ye, Huifen24
刊名: JOURNAL OF MEDICAL MICROBIOLOGY
发表日期: 2013-09-01
DOI: 10.1099/jmm.0.059816-0
卷: 62, 页:1343-1349
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology
研究领域[WOS]: Microbiology
关键词[WOS]: SPECTRUM-BETA-LACTAMASE ; GRAM-NEGATIVE BACILLI ; IN-VITRO SUSCEPTIBILITIES ; RESISTANCE TRENDS SMART ; ENTEROBACTERIACEAE ; EMERGENCE ; WORLDWIDE ; ESBLS
英文摘要:

The objective of this study was to investigate the susceptibility of hospital-associated (HA) and community-associated (CA) Escherichia coli and Klebsiella pneumoniae isolated from patients with intra-abdominal infections (IAIs) in China. From 2002 to 2011, the minimum inhibitory concentrations (MICs) of 12 antibiotics against 3074 E. coli and 1025 K. pneumoniae from 23 centres located in 16 cities were determined by the broth microdilution method. During the 10 year study period, ertapenem, imipenem, amikacin and piperacillin-tazobactam retained high and stable activity against E. coli and K pneumoniae isolates regardless of whether their source was HA or CA and regardless of their extended-spectrum beta-lactamase (ESBL) production. However, the susceptibility of E coli to cephalosporins and ampicillin-sulbactam decreased dramatically during the 10 years, especially for the CA isolates. Fluoroquinolones showed low activity against E. coli. During the whole study period, the ESBL rates for E. coli isolates from IAIs increased from 36.1% in 2002-2003 to 68.1% in 2010-2011 (P<0.001). Correspondingly, the ESBL rates in HA isolates increased from 52.2% in 2002-2003 to 70.0% in 2010-2011 (P=0.001), and in CA isolates from 19.1% in 2002-2003 to 61.6% in 2010-2011 (P<0.001). The ESBL-positive rate in K. pneumoniae remained between 30.1 and 39.3% of the total isolates with no significant change during the 10 years. In conclusion, carbapenems retained the highest susceptibility rates against HA and CA E. coli and K. pneumoniae. High prevalence of ESBL in HA E. coli and fast-growing resistance in CA E. coli severely limit the empirical use of the third- and fourth-generation cephalosporins in the therapy of IAIs.

语种: 英语
所属项目编号: 81101287 ; 201002021
项目资助者: Merck Co., Inc. ; National Natural Science Foundation of China ; Research Special Fund for Public Welfare Industry of Health of China
WOS记录号: WOS:000326304700012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68204
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Fu Dan Univ, Zhong Shan Hosp, Shanghai 200032, Peoples R China
2.Int Hlth Management Associates Inc, Schaumburg, IL 60173 USA
3.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
4.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Clin Lab, Beijing 100730, Peoples R China
5.Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Shanghai 200025, Peoples R China
6.Zhejiang Univ, Sir RunRun Shaw Hosp, Sch Med, Hangzhou 310016, Zhejiang, Peoples R China
7.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan 430030, Peoples R China
8.Chongqing Med Univ, Affiliated Hosp 1, Chongqing 400016, Peoples R China
9.Shandong Prov Hosp, Jinan 250021, Peoples R China
10.Cent Southern Univ, Xiangya Hosp, Changsha 410008, Hunan, Peoples R China
11.Zhengzhou Univ, Affiliated Hosp 1, Zhenzhou 450052, Peoples R China
12.Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China
13.Gen Hosp PLA, Beijing 100853, Peoples R China
14.Tianjin Med Univ, Gen Hosp, Tianjin 300052, Peoples R China
15.Chinese Med Univ, Affiliated Hosp 1, Shenyang 110001, Peoples R China
16.Harbin Med Univ, Affiliated Hosp 1, Harbin 150001, Peoples R China
17.Capital Med Coll, Chaoyang Hosp, Beijing 100020, Peoples R China
18.Capital Med Coll, Friendship Hosp, Beijing 100020, Peoples R China
19.Nanchang Univ, Affiliated Hosp 2, Nanchang 330006, Peoples R China
20.Peoples Hosp Haikou City, Haikou 570208, Peoples R China
21.Nanjing Mil Command, Gen Hosp, Nanjing 210002, Jiangsu, Peoples R China
22.Zhejiang Univ, Affiliated Hosp 1, Hangzhou 310003, Zhejiang, Peoples R China
23.Beijing Hosp, Beijing 100730, Peoples R China
24.Guangzhou First Municipal Peoples Hosp, Guangzhou 510180, Guangdong, Peoples R China

Recommended Citation:
Yang, Qiwen,Zhang, Hui,Wang, Yao,et al. A 10 year surveillance for antimicrobial susceptibility of Escherichia coli and Klebsiella pneumoniae in community- and hospital-associated intra-abdominal infections in China[J]. JOURNAL OF MEDICAL MICROBIOLOGY,2013,62:1343-1349.
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