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学科主题: 基础医学
题名:
PHF23 (plant homeodomain finger protein 23) negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1
作者: Wang, Zhenda1,2; Hu, Jia1,2; Li, Ge1,2; Qu, Liujing1,2; He, Qihua3; Lou, Yaxin3; Song, Quansheng1,2; Ma, Dalong1,2; Chen, Yingyu1,2
关键词: autophagy ; PHD domain ; PHF23 ; LRSAM1 ; ubiquitination
刊名: AUTOPHAGY
发表日期: 2014-12-01
DOI: 10.4161/auto.36439
卷: 10, 期:12, 页:2158-2170
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: MARIE-TOOTH DISEASE ; UNANSWERED QUESTIONS ; ADAPTER PROTEINS ; SELF-DIGESTION ; PHD FINGERS ; P62/SQSTM1 ; CANCER ; NDP52 ; LC3 ; DYSREGULATION
英文摘要:

Autophagy is a multistep process that involves the degradation and digestion of intracellular components by the lysosome. It has been proved that many core autophagy-related molecules participate in this event. However, new component proteins that regulate autophagy are still being discovered. At present, we report PHF23 (PHD finger protein 23) with a PHD-like zinc finger domain that can negatively regulate autophagy. Data from experiments indicated that the overexpression of PHF23 impaired autophagy, as characterized by decreased levels of LC3B-II and weakened degradation of endogenous and exogenous autophagic substrates. Conversely, knockdown of PHF23 resulted in opposite effects. Molecular mechanism studies suggested that PHF23 interacts with LRSAM1, which is an E3 ligase key for ubiquitin-dependent autophagy against invading bacteria. PHF23 promotes the ubiquitination and proteasome degradation of LRSAM1. We also show that the PHD finger of PHF23 is a functional domain needed for the interaction with LRSAM1. Altogether, our results indicate that PHF23 is a negative regulator associated in autophagy via the LRSAM1 signaling pathway. The physical and functional connection between the PHF23 and LRSAM1 needs further investigation.

语种: 英语
所属项目编号: 2011CB910103 ; 20130001110015
项目资助者: National Key Basic Research Program of China (973) ; Doctoral Program of the Ministry of Education
WOS记录号: WOS:000348598200006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68212
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Minist Hlth, Key Lab Med Immunol, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100871, Peoples R China
3.Peking Univ, Med & Hlth Analyt Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Wang, Zhenda,Hu, Jia,Li, Ge,et al. PHF23 (plant homeodomain finger protein 23) negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1[J]. AUTOPHAGY,2014,10(12):2158-2170.
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