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学科主题基础医学
PHF23 (plant homeodomain finger protein 23) negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1
Wang, Zhenda1,2; Hu, Jia1,2; Li, Ge1,2; Qu, Liujing1,2; He, Qihua3; Lou, Yaxin3; Song, Quansheng1,2; Ma, Dalong1,2; Chen, Yingyu1,2
关键词autophagy PHD domain PHF23 LRSAM1 ubiquitination
刊名AUTOPHAGY
2014-12-01
DOI10.4161/auto.36439
10期:12页:2158-2170
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]MARIE-TOOTH DISEASE ; UNANSWERED QUESTIONS ; ADAPTER PROTEINS ; SELF-DIGESTION ; PHD FINGERS ; P62/SQSTM1 ; CANCER ; NDP52 ; LC3 ; DYSREGULATION
英文摘要

Autophagy is a multistep process that involves the degradation and digestion of intracellular components by the lysosome. It has been proved that many core autophagy-related molecules participate in this event. However, new component proteins that regulate autophagy are still being discovered. At present, we report PHF23 (PHD finger protein 23) with a PHD-like zinc finger domain that can negatively regulate autophagy. Data from experiments indicated that the overexpression of PHF23 impaired autophagy, as characterized by decreased levels of LC3B-II and weakened degradation of endogenous and exogenous autophagic substrates. Conversely, knockdown of PHF23 resulted in opposite effects. Molecular mechanism studies suggested that PHF23 interacts with LRSAM1, which is an E3 ligase key for ubiquitin-dependent autophagy against invading bacteria. PHF23 promotes the ubiquitination and proteasome degradation of LRSAM1. We also show that the PHD finger of PHF23 is a functional domain needed for the interaction with LRSAM1. Altogether, our results indicate that PHF23 is a negative regulator associated in autophagy via the LRSAM1 signaling pathway. The physical and functional connection between the PHF23 and LRSAM1 needs further investigation.

语种英语
WOS记录号WOS:000348598200006
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被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68212
专题北京大学基础医学院_免疫学系
北京大学医学部管理机构_医学部
北京大学基础医学院
北京大学口腔医学院_儿童口腔科
作者单位1.Peking Univ, Hlth Sci Ctr, Minist Hlth, Key Lab Med Immunol, Beijing 100871, Peoples R China
2.Peking Univ, Ctr Human Dis Genom, Beijing 100871, Peoples R China
3.Peking Univ, Med & Hlth Analyt Ctr, Beijing 100871, Peoples R China
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GB/T 7714
Wang, Zhenda,Hu, Jia,Li, Ge,et al. PHF23 (plant homeodomain finger protein 23) negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1[J]. AUTOPHAGY,2014,10(12):2158-2170.
APA Wang, Zhenda.,Hu, Jia.,Li, Ge.,Qu, Liujing.,He, Qihua.,...&Chen, Yingyu.(2014).PHF23 (plant homeodomain finger protein 23) negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1.AUTOPHAGY,10(12),2158-2170.
MLA Wang, Zhenda,et al."PHF23 (plant homeodomain finger protein 23) negatively regulates cell autophagy by promoting ubiquitination and degradation of E3 ligase LRSAM1".AUTOPHAGY 10.12(2014):2158-2170.
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