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学科主题: 基础医学
题名:
Bone marrow mononuclear cell transplantation into heart elevates the expression of angiogenic factors
作者: Liu, YG; Guo, JX; Zhang, P; Zhang, SH; Chen, P; Ma, K; Zhou, CY
关键词: angiogenesis ; hepatocyte growth factor ; c-met ; fibroblast growth factor ; insulin growth factor ; transforming growth factor ; platelet-derived growth factor ; myocardial infarction ; stem cells transplantation
刊名: MICROVASCULAR RESEARCH
发表日期: 2004-11-01
DOI: 10.1016/j.mvr.2004.06.008
卷: 68, 期:3, 页:156-160
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: ENHANCES COLLATERAL PERFUSION ; HEPATOCYTE GROWTH-FACTOR ; STEM-CELLS ; INFARCTED MYOCARDIUM ; REGIONAL FUNCTION ; REGENERATION ; RATS ; FAILURE ; MUSCLE
英文摘要:

The expression of angiogenic factors was measured to elucidate the mechanism of angiogenesis after bone marrow stem cells transplantation. The left anterior descending coronary (LAD) artery was ligated in male Lewis rats to induce an acute myocardial infarction (AMI); of which, some rats received bone marrow mononuclear cells transplantation (BMT). The expression of cytokines and their receptors was assessed by RT-PCR. The expression of c-met was upregulated in the ANH animals and was further increased when the animals received BMT (P < 0.01). The other cytokines and their receptors remained unchanged after BMT compared with AMI samples. Normal bone marrow mononuclear cells have higher expression level of hepatocyte growth factor (HGF) than those in normal hearts. In conclusion, BMT could increase the expression of c-met. Not all angiogenic cytokines and their receptors were upregulated after BMT. The higher expression of hepatocyte growth factor in bone marrow may contribute to the upregulation of c-met. (C) 2004 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000224910000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68213
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China
2.Peking Univ, Dept Cardiol, Hosp 3, Beijing 100083, Peoples R China

Recommended Citation:
Liu, YG,Guo, JX,Zhang, P,et al. Bone marrow mononuclear cell transplantation into heart elevates the expression of angiogenic factors[J]. MICROVASCULAR RESEARCH,2004,68(3):156-160.
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