IR@PKUHSC  > 基础医学院  > 免疫学系
学科主题基础医学
An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer
Xu, Qing-Wen1; Zhao, Wei1; Wang, Yue9,10; Sartor, Maureen A.11; Han, Dong-Mei2; Deng, Jixin8; Ponnala, Rakesh9,10; Yang, Jiang-Ying3; Zhang, Qing-Yun3; Liao, Guo-Qing4; Qu, Yi-Mei4; Li, Lu5; Liu, Fang-Fang6; Zhao, Hong-Mei7; Yin, Yan-Hui1; Chen, Wei-Feng1; Zhang, Yu1; Wang, Xiao-Song9,10
刊名CANCER RESEARCH
2012-12-15
DOI10.1158/0008-5472.CAN-12-1656
72期:24页:6351-6361
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Natural Science Foundation of China ; National High-tech R& ; D Program of China (863 Program) ; National Basic Research Program of China (973 Program) ; Congressionally Directed Medical Research Programs ; NIH ; NCRR ; National Natural Science Foundation of China ; National High-tech R& ; D Program of China (863 Program) ; National Basic Research Program of China (973 Program) ; Congressionally Directed Medical Research Programs ; NIH ; NCRR
研究领域[WOS]Oncology
关键词[WOS]PROSTATE-CANCER ; HEPATOCELLULAR-CARCINOMA ; SERUM AUTOANTIBODIES ; METASTATIC MELANOMA ; COLORECTAL-CANCER ; SIPULEUCEL-T ; LUNG-CANCER ; VACCINE ; GENE ; IMMUNOTHERAPY
英文摘要

Tumor-specific antigens (TSA) are central elements in the immune control of cancers. To systematically explore the TSA genome, we developed a computational technology called heterogeneous expression profile analysis (HEPA), which can identify genes relatively uniquely expressed in cancer cells in contrast to normal somatic tissues. Rating human genes by their HEPA score enriched for clinically useful TSA genes, nominating candidate targets whose tumor-specific expression was verified by reverse transcription PCR (RT-PCR). Coupled with HEPA, we designed a novel assay termed protein A/G-based reverse serological evaluation (PARSE) for quick detection of serum autoantibodies against an array of putative TSA genes. Remarkably, highly tumor-specific autoantibody responses against seven candidate targets were detected in 4% to 11% of patients, resulting in distinctive autoantibody signatures in lung and stomach cancers. Interrogation of a larger cohort of 149 patients and 123 healthy individuals validated the predictive value of the autoantibody signature for lung cancer. Together, our results establish an integrated technology to uncover a cancer-specific antigen genome offering a reservoir of novel immunologic and clinical targets. Cancer Res; 72(24); 6351-61. (c) 2012 AACR.

语种英语
所属项目编号30525044 ; 30830091 ; 2007AA021103 ; 2011CB946100 ; W81XWH-12-1-0166 ; P30-125123-06 ; S10RR02950
资助者National Natural Science Foundation of China ; National High-tech R& ; D Program of China (863 Program) ; National Basic Research Program of China (973 Program) ; Congressionally Directed Medical Research Programs ; NIH ; NCRR ; National Natural Science Foundation of China ; National High-tech R& ; D Program of China (863 Program) ; National Basic Research Program of China (973 Program) ; Congressionally Directed Medical Research Programs ; NIH ; NCRR
WOS记录号WOS:000312591900006
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68214
专题基础医学院_免疫学系
作者单位1.Peoples Liberat Army AF Gen Hosp, Dept Hematol, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100191, Peoples R China
3.Peking Univ, Dept Clin Lab, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100191, Peoples R China
4.Peoples Liberat Army 309 Hosp, Dept Oncol, Beijing, Peoples R China
5.Peoples Liberat Army 306 Hosp, Dept Cardiothorac Surg, Beijing, Peoples R China
6.Peking Univ, Dept Pathol, Peoples Hosp, Beijing 100191, Peoples R China
7.Peking Univ, Dept Surg, Hosp 3, Beijing 100191, Peoples R China
8.Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA
9.Baylor Coll Med, Lester & Sue Smith Breast Ctr, Houston, TX 77030 USA
10.Baylor Coll Med, Dan L Duncan Canc Ctr, Houston, TX 77030 USA
11.Univ Michigan, Natl Ctr Integrat Biomed Informat, Ctr Computat Med & Bioinformat, Ann Arbor, MI 48109 USA
推荐引用方式
GB/T 7714
Xu, Qing-Wen,Zhao, Wei,Wang, Yue,et al. An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer[J]. CANCER RESEARCH,2012,72(24):6351-6361.
APA Xu, Qing-Wen.,Zhao, Wei.,Wang, Yue.,Sartor, Maureen A..,Han, Dong-Mei.,...&Wang, Xiao-Song.(2012).An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer.CANCER RESEARCH,72(24),6351-6361.
MLA Xu, Qing-Wen,et al."An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer".CANCER RESEARCH 72.24(2012):6351-6361.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
6351.full.pdf(2105KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Xu, Qing-Wen]的文章
[Zhao, Wei]的文章
[Wang, Yue]的文章
百度学术
百度学术中相似的文章
[Xu, Qing-Wen]的文章
[Zhao, Wei]的文章
[Wang, Yue]的文章
必应学术
必应学术中相似的文章
[Xu, Qing-Wen]的文章
[Zhao, Wei]的文章
[Wang, Yue]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 6351.full.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。