北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 免疫学系  > 期刊论文
学科主题: 基础医学
题名:
An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer
作者: Xu, Qing-Wen1; Zhao, Wei1; Wang, Yue9,10; Sartor, Maureen A.11; Han, Dong-Mei2; Deng, Jixin8; Ponnala, Rakesh9,10; Yang, Jiang-Ying3; Zhang, Qing-Yun3; Liao, Guo-Qing4; Qu, Yi-Mei4; Li, Lu5; Liu, Fang-Fang6; Zhao, Hong-Mei7; Yin, Yan-Hui1; Chen, Wei-Feng1; Zhang, Yu1; Wang, Xiao-Song9,10
刊名: CANCER RESEARCH
发表日期: 2012-12-15
DOI: 10.1158/0008-5472.CAN-12-1656
卷: 72, 期:24, 页:6351-6361
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: PROSTATE-CANCER ; HEPATOCELLULAR-CARCINOMA ; SERUM AUTOANTIBODIES ; METASTATIC MELANOMA ; COLORECTAL-CANCER ; SIPULEUCEL-T ; LUNG-CANCER ; VACCINE ; GENE ; IMMUNOTHERAPY
英文摘要:

Tumor-specific antigens (TSA) are central elements in the immune control of cancers. To systematically explore the TSA genome, we developed a computational technology called heterogeneous expression profile analysis (HEPA), which can identify genes relatively uniquely expressed in cancer cells in contrast to normal somatic tissues. Rating human genes by their HEPA score enriched for clinically useful TSA genes, nominating candidate targets whose tumor-specific expression was verified by reverse transcription PCR (RT-PCR). Coupled with HEPA, we designed a novel assay termed protein A/G-based reverse serological evaluation (PARSE) for quick detection of serum autoantibodies against an array of putative TSA genes. Remarkably, highly tumor-specific autoantibody responses against seven candidate targets were detected in 4% to 11% of patients, resulting in distinctive autoantibody signatures in lung and stomach cancers. Interrogation of a larger cohort of 149 patients and 123 healthy individuals validated the predictive value of the autoantibody signature for lung cancer. Together, our results establish an integrated technology to uncover a cancer-specific antigen genome offering a reservoir of novel immunologic and clinical targets. Cancer Res; 72(24); 6351-61. (c) 2012 AACR.

语种: 英语
所属项目编号: 30525044 ; 30830091 ; 2007AA021103 ; 2011CB946100 ; W81XWH-12-1-0166 ; P30-125123-06 ; S10RR02950
项目资助者: National Natural Science Foundation of China ; National High-tech R& ; D Program of China (863 Program) ; National Basic Research Program of China (973 Program) ; Congressionally Directed Medical Research Programs ; NIH ; NCRR
WOS记录号: WOS:000312591900006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68214
Appears in Collections:基础医学院_免疫学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
6351.full.pdf(2105KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Peoples Liberat Army AF Gen Hosp, Dept Hematol, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100191, Peoples R China
3.Peking Univ, Dept Clin Lab, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100191, Peoples R China
4.Peoples Liberat Army 309 Hosp, Dept Oncol, Beijing, Peoples R China
5.Peoples Liberat Army 306 Hosp, Dept Cardiothorac Surg, Beijing, Peoples R China
6.Peking Univ, Dept Pathol, Peoples Hosp, Beijing 100191, Peoples R China
7.Peking Univ, Dept Surg, Hosp 3, Beijing 100191, Peoples R China
8.Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA
9.Baylor Coll Med, Lester & Sue Smith Breast Ctr, Houston, TX 77030 USA
10.Baylor Coll Med, Dan L Duncan Canc Ctr, Houston, TX 77030 USA
11.Univ Michigan, Natl Ctr Integrat Biomed Informat, Ctr Computat Med & Bioinformat, Ann Arbor, MI 48109 USA

Recommended Citation:
Xu, Qing-Wen,Zhao, Wei,Wang, Yue,et al. An Integrated Genome-Wide Approach to Discover Tumor-Specific Antigens as Potential Immunologic and Clinical Targets in Cancer[J]. CANCER RESEARCH,2012,72(24):6351-6361.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xu, Qing-Wen]'s Articles
[Zhao, Wei]'s Articles
[Wang, Yue]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xu, Qing-Wen]‘s Articles
[Zhao, Wei]‘s Articles
[Wang, Yue]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace