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学科主题临床医学
Regulation of lung fibroblast activation by annexin A1
Jia, Yuan1,2; Morand, Eric F.1; Song, Wuqi1,3; Cheng, Qiang1; Stewart, Alastair4; Yang, Yuan H.1
刊名JOURNAL OF CELLULAR PHYSIOLOGY
2013-02-01
DOI10.1002/jcp.24156
228期:2页:476-484
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Physiology
研究领域[WOS]Cell Biology ; Physiology
关键词[WOS]INDUCED LEUCINE-ZIPPER ; FORMYL PEPTIDE RECEPTORS ; LIPOXIN A(4) RECEPTOR ; RHEUMATOID-ARTHRITIS ; UP-REGULATION ; GLUCOCORTICOID ACTIONS ; PULMONARY-FIBROSIS ; PROTEIN-KINASES ; GENE-EXPRESSION ; CELL-LINE
英文摘要

Annexin-A1 (AnxA1) is a glucocorticoid-induced protein with multiple actions in the regulation of inflammatory cell activation. The contribution of AnxA1 to human cell biology is not well understood. We investigated the contribution of AnxA1 and its receptor, formyl-peptide receptor 2 (FPR2), to the regulation of inflammatory responses in human normal lung fibroblasts (NLF). Silencing constitutive AnxA1 expression in NLF using small interfering RNA (siRNA) was associated with moderate but significant increases in tumor necrosis factor (TNF)-induced proliferation and interleukin (IL)-6 production, accompanied by reduction of ERK and NF-kappa B activity. AnxA1 regulation of ERK and NF-kappa B activation was associated with effects on proliferation. Blocking FPR2 using the specific antagonist WRW4 mimicked the effects of AnxA1 silencing on TNF-induced proliferation, IL-6, ERK, and NF-kappa B activation. AnxA1 silencing also impaired inhibitory effects of glucocorticoid on IL-6 production and on the expression of glucocorticoid-induced leucine zipper (GILZ), but blocking FPR2 failed to mimic these effects of AnxA1 silencing. These data suggest that AnxA1 regulates TNF-induced proliferation and inflammatory responses in lung fibroblasts, via effects on the ERK and NF-kappa B pathways, which depend on FPR2. AnxA1 also mediates effects of glucocorticoids and GILZ expression, but these effects appear independent of FPR2. These findings suggest that mimicking AnxA1 actions might have therapeutic potential in chronic inflammatory lung diseases. J. Cell. Physiol. 228: 476484, 2013. (C) 2012 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000310486200026
项目编号ID436692
资助机构Australian National Health and Medical Research Council
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68227
专题北京大学第二临床医学院
北京大学第二临床医学院_风湿免疫科
作者单位1.Monash Univ, Ctr Inflammatory Dis, So Clin Sch, Fac Med Nursing & Hlth Sci,Monash Med Ctr, Clayton, Vic 3168, Australia
2.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China
3.Harbin Med Univ, Heilongjiang Key Lab Immun & Infect, Dept Microbiol, Harbin, Peoples R China
4.Univ Melbourne, Dept Pharmacol, Parkville, Vic 3052, Australia
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GB/T 7714
Jia, Yuan,Morand, Eric F.,Song, Wuqi,et al. Regulation of lung fibroblast activation by annexin A1[J]. JOURNAL OF CELLULAR PHYSIOLOGY,2013,228(2):476-484.
APA Jia, Yuan,Morand, Eric F.,Song, Wuqi,Cheng, Qiang,Stewart, Alastair,&Yang, Yuan H..(2013).Regulation of lung fibroblast activation by annexin A1.JOURNAL OF CELLULAR PHYSIOLOGY,228(2),476-484.
MLA Jia, Yuan,et al."Regulation of lung fibroblast activation by annexin A1".JOURNAL OF CELLULAR PHYSIOLOGY 228.2(2013):476-484.
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