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学科主题: 临床医学
题名:
Glucose and lipid metabolism in small-for-gestational-age infants at 72 hours of age
作者: Wang, Xinli; Cui, Yunpu; Tong, Xiaomei; Ye, Hongmao; Li, Song
刊名: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
发表日期: 2007-02-01
DOI: 10.1210/jc.2006-1281
卷: 92, 期:2, 页:681-684
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: INSULIN-RESISTANCE SYNDROME ; LOW-BIRTH-WEIGHT ; CARDIOVASCULAR-DISEASE ; LIPOPROTEIN-LIPASE ; ADULT LIFE ; GROWTH ; FETAL ; SENSITIVITY ; ASSOCIATION ; HYPOTHESIS
英文摘要:

Context: Reduced birth weight is associated with increased risk for the insulin resistance syndrome. Part of this risk is hypothesized to originate from intrauterine growth retardation.

Objective: The aim of this study is to determine whether or not the components of the insulin resistance syndrome are associated with reduced fetal growth.

Design: This was a case-control study.

Setting: The study was conducted in Beijing, China.

Participants: Included in this study were 296 singleton neonates ( 177 males and 119 females), including 76 ( 37 preterm and 39 fullterm newborns) classified as small for gestational age ( SGA) and 220 who were appropriate for gestational age ( AGA) ( 84 preterm and 136 full-term newborns).

Main Outcome Measures: The main outcome measures were post-absorptive glucose, insulin, and lipids levels on the third day after birth.

Results: Both full-term and preterm SGA neonates had higher insulin concentrations ( mean +/- SEM, 17.11 +/- 1.15 vs. 6.80 +/- 0.62 mu IU/ml in full-term, P < 0.01; 11.99 +/- 1.18 vs. 8.37 +/- 0.78 mu IU/ml in preterm, P = 0.03), insulin to glucose ratios ( 4.48 +/- 0.37 vs. 1.78 +/- 0.20 in full-term, P < 0.01; 3.28 +/- 0.38 vs. 2.30 +/- 0.26 in preterm, P = 0.03), triglycerides ( 2.29 +/- 0.23 vs. 1.57 +/- 0.13 mmol/liter in full-term, P < 0.01; 2.27 +/- 0.16 vs. 1.34 +/- 0.11 mmol/liter in preterm, P < 0.01), total cholesterol ( 2.35 +/- 0.12 vs. 1.82 +/- 0.22 mmol/liter in full-term, P = 0.04; 2.57 +/- 0.22 vs. 1.95 +/- 0.15 mmol/liter in preterm, P = 0.02), and low-density lipoprotein cholesterol ( 2.11 +/- 0.58 vs. 1.24 +/- 0.61 mmol/liter in full-term, P = 0.01; 1.87 +/- 0.60 vs. 1.38 +/- 0.59 mmol/liter in preterm, P < 0.01) concentrations than did AGA neonates; however, they had similar glucose levels. Among AGA infants, insulin concentration, insulin to glucose ratios, and lipids levels did not significantly differ between full-term and preterm babies.

Conclusions: In this study, SGA neonates displayed profiles suggestive of lower insulin sensitivity and less favorable lipid metabolism in the early postnatal period.

语种: 英语
WOS记录号: WOS:000244064900054
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68228
Appears in Collections:北京大学第三临床医学院_儿科_期刊论文

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作者单位: Peking Univ, Dept Pediat, Hosp 3, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Xinli,Cui, Yunpu,Tong, Xiaomei,et al. Glucose and lipid metabolism in small-for-gestational-age infants at 72 hours of age[J]. JOURNAL OF CLINICAL ENDOCRINOLOGY &amp; METABOLISM,2007,92(2):681-684.
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