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High serum level of lutein may be protective against early atherosclerosis: The Beijing atherosclerosis study
Zou, Zhiyong; Xu, Xianrong; Huang, Yangmu; Xiao, Xin; Ma, Le; Sun, Tingting; Dong, Pengcheng; Wang, Xun; Lin, Xiaoming
关键词Lutein Early atherosclerosis Intima-media thickness Arterial stiffness Serum carotenoid
刊名ATHEROSCLEROSIS
2011-12-01
DOI10.1016/j.atherosclerosis.2011.08.006
219期:2页:789-793
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]INTIMA-MEDIA THICKNESS ; LOS-ANGELES-ATHEROSCLEROSIS ; CORONARY-HEART-DISEASE ; ANTIOXIDANT VITAMINS ; BETA-CAROTENE ; ARTERIAL STIFFNESS ; RISK ; SUPPLEMENTATION ; PROGRESSION ; MORTALITY
英文摘要

Objective: We investigated whether early atherosclerosis before calcified plaque appeared as assessed by carotid intima-media thickness (IMT) was associated with levels of the major carotenoids, and assessed the associations among these serum carotenoids, carotid IMT, and arterial stiffness.

Methods: The case-control study comprised 125 subjects with early atherosclerosis and 107 controls aged 45-68 years. We simultaneously measured common carotid IMT and arterial stiffness by carotid ultrasonography, and serum carotenoids were determined by high-pressure liquid chromatograph (HPLC).

Results: In cases of early atherosclerosis, serum level of lutein was significantly lower than that in controls. Serum lutein was inversely associated with carotid IMT. Zeaxanthin and p-carotene were both negatively correlated with right common carotid artery stiffness)8, elastic modulus (Er), and pulse wave velocity (PWV). After adjusting for age and gender, the associations remain significantly (P < 0.05). However, there is no significant difference for zeaxanthin and p-carotene between the cases and controls.

Conclusion: These findings suggest that lutein may play a protective role in the prevention of early atherosclerosis, and the associations between serum carotenoids and arterial stiffness remained to be investigated. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

语种英语
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000298813900069
Citation statistics
Cited Times:25[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68237
Collection北京大学公共卫生学院
作者单位Peking Univ, Dept Food Hyg & Nutr, Sch Publ Hlth, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Zou, Zhiyong,Xu, Xianrong,Huang, Yangmu,et al. High serum level of lutein may be protective against early atherosclerosis: The Beijing atherosclerosis study[J]. ATHEROSCLEROSIS,2011,219(2):789-793.
APA Zou, Zhiyong.,Xu, Xianrong.,Huang, Yangmu.,Xiao, Xin.,Ma, Le.,...&Lin, Xiaoming.(2011).High serum level of lutein may be protective against early atherosclerosis: The Beijing atherosclerosis study.ATHEROSCLEROSIS,219(2),789-793.
MLA Zou, Zhiyong,et al."High serum level of lutein may be protective against early atherosclerosis: The Beijing atherosclerosis study".ATHEROSCLEROSIS 219.2(2011):789-793.
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