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学科主题: 基础医学
题名:
LAPTM4B gene polymorphism and endometrial carcinoma risk and prognosis
作者: Meng, Fanling1; Li, Huiyan2; Zhou, Rouli3; Luo, Chang4; Hu, Yuanlong5; Lou, Ge1
关键词: Endometrial carcinoma ; gene polymorphism ; LAPTM4B ; prognosis ; susceptibility
刊名: BIOMARKERS
发表日期: 2013-03-01
DOI: 10.3109/1354750X.2012.752526
卷: 18, 期:2, 页:136-143
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Toxicology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Toxicology
关键词[WOS]: HEPATOCELLULAR-CARCINOMA ; CERVICAL-CARCINOMA ; BREAST-CANCER ; OVEREXPRESSION ; SUSCEPTIBILITY ; AMPLIFICATION ; PROGRESSION ; METASTASIS ; RESISTANCE ; AUTOPHAGY
英文摘要:

A novel gene called LAPTM4B (lysosome-associated protein transmembrane 4 beta) plays several crucial roles in carcinogenesis. In this case-control study, we investigated the relationship between LAPTM4B gene polymorphism and susceptibility to endometrial carcinoma (EC). In an adjusted multivariate logistic regression analyses, subjects with the LAPTM4B*1/2 and *2/2 genotypes respectively exhibited 1.572-fold (95% confidence interval (CI) = 1.041-2.375) and 2.335-fold (95% CI = 1.365-3.995) increases in the risk of developing EC relative to those carrying LAPTM4B*1/1. Patients with LAPTM4B *2 had both significantly shorter overall survival (OS) and shorter disease-free survival (DFS) (both p < 0.001). Multivariate analysis showed that LAPTM4B genotype is an independent prognostic factor for OS and DFS (both p < 0.001). These results suggest that LAPTM4B polymorphisms might play an important role in the aetiology of EC.

语种: 英语
WOS记录号: WOS:000314976000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68240
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Red Cross Cent Hosp, Dept Birth Control, Harbin, Peoples R China
2.Fifth Hosp, Dept Orthopaed, Harbin 150040, Peoples R China
3.Harbin Med Univ, Affiliated Tumour Hosp, Dept Gynaecol, Harbin 150081, Peoples R China
4.Harbin Med Univ, Affiliated Tumour Hosp, Dept Radiotherapy, Harbin 150081, Peoples R China
5.Peking Univ, Sch Basic Med Sci, Dept Cell Biol & Genet, Beijing 100871, Peoples R China

Recommended Citation:
Meng, Fanling,Li, Huiyan,Zhou, Rouli,et al. LAPTM4B gene polymorphism and endometrial carcinoma risk and prognosis[J]. BIOMARKERS,2013,18(2):136-143.
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