IR@PKUHSC  > 北京大学临床肿瘤学院  > 病理科
学科主题临床医学
The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein
Zhong, XY; Liu, LM; Zhao, AL; Pfeifer, GP; Xu, XZ
关键词primary microcephaly Drosophila asp ASPM centrosome spindle BRCA1 small interfering RNA
刊名CELL CYCLE
2005-09-01
4期:9页:1227-1229
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]MITOTIC SPINDLE ; DNA-DAMAGE ; BRAIN SIZE ; DROSOPHILA ; BRCA1 ; CHECKPOINT ; CYTOKINESIS ; MUTATIONS ; MITOSIS ; CHK1
英文摘要

Homozygous mutations in the abnormal spindle-like, microcephaly-associated ASPM gene are the leading cause of autosomal recessive primary microcephaly. ASPM is the putative human ortholog of the Drosophila melanogaster abnormal spindles gene ( asp), which is essential for mitotic spindle function. Here, we report that downregulation of endogenous ASPM by siRNA decreases protein levels of endogenous BRCA1. ASPM localizes to the centrosome in interphase and to the spindle poles from prophase through telophase. These findings indicate that ASPM may be involved in mitotic spindle function, possibly, through regulation of BRCA1.

语种英语
WOS记录号WOS:000231512900021
引用统计
被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68241
专题北京大学临床肿瘤学院_病理科
作者单位1.City Hope Natl Med Ctr, Beckman Res Inst, Div Biol, Duarte, CA 91010 USA
2.Peking Univ, Sch Oncol, Dept Pathol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhong, XY,Liu, LM,Zhao, AL,et al. The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein[J]. CELL CYCLE,2005,4(9):1227-1229.
APA Zhong, XY,Liu, LM,Zhao, AL,Pfeifer, GP,&Xu, XZ.(2005).The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein.CELL CYCLE,4(9),1227-1229.
MLA Zhong, XY,et al."The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein".CELL CYCLE 4.9(2005):1227-1229.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zhong, XY]的文章
[Liu, LM]的文章
[Zhao, AL]的文章
百度学术
百度学术中相似的文章
[Zhong, XY]的文章
[Liu, LM]的文章
[Zhao, AL]的文章
必应学术
必应学术中相似的文章
[Zhong, XY]的文章
[Liu, LM]的文章
[Zhao, AL]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。