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IR@PKUHSC  > 北京大学临床肿瘤学院  > 病理科  > 期刊论文
学科主题: 临床医学
题名:
The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein
作者: Zhong, XY; Liu, LM; Zhao, AL; Pfeifer, GP; Xu, XZ
关键词: primary microcephaly ; Drosophila asp ; ASPM ; centrosome ; spindle ; BRCA1 ; small interfering RNA
刊名: CELL CYCLE
发表日期: 2005-09-01
卷: 4, 期:9, 页:1227-1229
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: MITOTIC SPINDLE ; DNA-DAMAGE ; BRAIN SIZE ; DROSOPHILA ; BRCA1 ; CHECKPOINT ; CYTOKINESIS ; MUTATIONS ; MITOSIS ; CHK1
英文摘要:

Homozygous mutations in the abnormal spindle-like, microcephaly-associated ASPM gene are the leading cause of autosomal recessive primary microcephaly. ASPM is the putative human ortholog of the Drosophila melanogaster abnormal spindles gene ( asp), which is essential for mitotic spindle function. Here, we report that downregulation of endogenous ASPM by siRNA decreases protein levels of endogenous BRCA1. ASPM localizes to the centrosome in interphase and to the spindle poles from prophase through telophase. These findings indicate that ASPM may be involved in mitotic spindle function, possibly, through regulation of BRCA1.

语种: 英语
WOS记录号: WOS:000231512900021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68241
Appears in Collections:北京大学临床肿瘤学院_病理科_期刊论文

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作者单位: 1.City Hope Natl Med Ctr, Beckman Res Inst, Div Biol, Duarte, CA 91010 USA
2.Peking Univ, Sch Oncol, Dept Pathol, Beijing 100871, Peoples R China

Recommended Citation:
Zhong, XY,Liu, LM,Zhao, AL,et al. The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein[J]. CELL CYCLE,2005,4(9):1227-1229.
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