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学科主题: 口腔医学
题名:
Sustained Inflammation Induces Degeneration of the Temporomandibular Joint
作者: Wang, X. D.2; Kou, X. X.2; Mao, J. J.1; Gan, Y. H.3; Zhou, Y. H.2
关键词: inflammation ; TMJ ; disc ; synovium ; collagen ; degenerative disease
刊名: JOURNAL OF DENTAL RESEARCH
发表日期: 2012-05-01
DOI: 10.1177/0022034512441946
卷: 91, 期:5, 页:499-505
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: ANTIGEN-INDUCED ARTHRITIS ; OVARIECTOMIZED RATS ; STEM-CELLS ; DISC ; EXPRESSION ; INTERLEUKIN-1-BETA ; MODEL ; COLLAGEN ; PAIN ; TMJ
英文摘要:

The temporomandibular joint (TMJ) undergoes degenerative changes among patients who suffer from arthritis, and yet the pathogenesis of TMJ osteoarthritis and rheumatoid arthritis is poorly understood. We hypothesized that sustained inflammation in the TMJ induces structural abnormalities, and accordingly characterized the disc and synovium in a novel model with double injections of complete Freund′s adjuvant (CFA), using behavioral, morphological, cellular, and molecular assessments. Thirty-five days following double CFA injections in seven-week-old female Sprague-Dawley rats, the disc in the CFA-induced inflammation group demonstrated multiple degenerative changes, including marked thickening, opacity, and deformation. The discs in the CFA group further showed significantly greater wet and net weights, and elevated collagen, aggrecan, and total glycosaminoglycan contents. The synovium in the CFA-induced inflammation group showed marked infiltration of mononucleated cells and accumulated sub-synovial adipose tissue. Both the disc and synovium had significantly higher iNOS and IL-1 beta mRNA expression than controls (saline injections). These findings are consistent with our hypothesis that sustained TMJ inflammation, even within the presently observed 35 days, may be a predisposing factor for structural abnormalities. Insight into TMJ inflammation and degeneration is anticipated to improve our understanding of the pathogenesis of TMJ arthritis and help design clinically relevant strategies for tissue engineering.

语种: 英语
所属项目编号: 2009DFB30370 ; R01DE015785 ; R01DE18248
项目资助者: China International Science and Technology Cooperation ; NIH/NIDCR
WOS记录号: WOS:000302916300011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68242
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Columbia Univ, Med Ctr, Coll Dent Med, Ctr Craniofacial Regenerat, New York, NY 10032 USA
2.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Oralfacial Pain, Beijing 100081, Peoples R China

Recommended Citation:
Wang, X. D.,Kou, X. X.,Mao, J. J.,et al. Sustained Inflammation Induces Degeneration of the Temporomandibular Joint[J]. JOURNAL OF DENTAL RESEARCH,2012,91(5):499-505.
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