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学科主题口腔医学
Sustained Inflammation Induces Degeneration of the Temporomandibular Joint
Wang, X. D.2; Kou, X. X.2; Mao, J. J.1; Gan, Y. H.3; Zhou, Y. H.2
关键词inflammation TMJ disc synovium collagen degenerative disease
刊名JOURNAL OF DENTAL RESEARCH
2012-05-01
DOI10.1177/0022034512441946
91期:5页:499-505
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]ANTIGEN-INDUCED ARTHRITIS ; OVARIECTOMIZED RATS ; STEM-CELLS ; DISC ; EXPRESSION ; INTERLEUKIN-1-BETA ; MODEL ; COLLAGEN ; PAIN ; TMJ
英文摘要

The temporomandibular joint (TMJ) undergoes degenerative changes among patients who suffer from arthritis, and yet the pathogenesis of TMJ osteoarthritis and rheumatoid arthritis is poorly understood. We hypothesized that sustained inflammation in the TMJ induces structural abnormalities, and accordingly characterized the disc and synovium in a novel model with double injections of complete Freund′s adjuvant (CFA), using behavioral, morphological, cellular, and molecular assessments. Thirty-five days following double CFA injections in seven-week-old female Sprague-Dawley rats, the disc in the CFA-induced inflammation group demonstrated multiple degenerative changes, including marked thickening, opacity, and deformation. The discs in the CFA group further showed significantly greater wet and net weights, and elevated collagen, aggrecan, and total glycosaminoglycan contents. The synovium in the CFA-induced inflammation group showed marked infiltration of mononucleated cells and accumulated sub-synovial adipose tissue. Both the disc and synovium had significantly higher iNOS and IL-1 beta mRNA expression than controls (saline injections). These findings are consistent with our hypothesis that sustained TMJ inflammation, even within the presently observed 35 days, may be a predisposing factor for structural abnormalities. Insight into TMJ inflammation and degeneration is anticipated to improve our understanding of the pathogenesis of TMJ arthritis and help design clinically relevant strategies for tissue engineering.

语种英语
WOS记录号WOS:000302916300011
项目编号2009DFB30370 ; R01DE015785 ; R01DE18248
资助机构China International Science and Technology Cooperation ; NIH/NIDCR
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68242
专题北京大学口腔医学院_牙周科
作者单位1.Columbia Univ, Med Ctr, Coll Dent Med, Ctr Craniofacial Regenerat, New York, NY 10032 USA
2.Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Oralfacial Pain, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Wang, X. D.,Kou, X. X.,Mao, J. J.,et al. Sustained Inflammation Induces Degeneration of the Temporomandibular Joint[J]. JOURNAL OF DENTAL RESEARCH,2012,91(5):499-505.
APA Wang, X. D.,Kou, X. X.,Mao, J. J.,Gan, Y. H.,&Zhou, Y. H..(2012).Sustained Inflammation Induces Degeneration of the Temporomandibular Joint.JOURNAL OF DENTAL RESEARCH,91(5),499-505.
MLA Wang, X. D.,et al."Sustained Inflammation Induces Degeneration of the Temporomandibular Joint".JOURNAL OF DENTAL RESEARCH 91.5(2012):499-505.
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