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学科主题基础医学
A Facile Synthesis of Small-Sized, Highly Photoluminescent, and Monodisperse CdSeS QD/SiO2 for Live Cell Imaging
Han, Rongcheng; Yu, Min; Zheng, Qiang; Wang, Lijun; Hong, Yuankai; Sha, Yinlin1
刊名LANGMUIR
2009-10-20
DOI10.1021/la9016596
25期:20页:12250-12255
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
研究领域[WOS]Chemistry ; Materials Science
关键词[WOS]QUANTUM-DOT-MICELLES ; REVERSE MICROEMULSION METHOD ; WATER-SOLUBLE NANOPARTICLES ; RECEPTOR-TARGETED DELIVERY ; FOLATE-RECEPTOR ; SILICA SPHERES ; SEMICONDUCTOR NANOCRYSTALS ; DRUG-DELIVERY ; PROBES ; SHELL
英文摘要

In recent years, silica coating has been extensively investigated to fabricate the biocompatible interface of quantum dots (QDs) for biomedical applications. We here describe a facile and efficient method of synthesizing high-quality silica-coated CdSeS QDs (CdSeS QD/SiO2), where an immediate photoluminescence-favorable microenvironment is first created by assembling amphiphilic molecules around the CdSeS core, and a thin silica shell is further introduced to protect this hydrophobic interlayer, The prepared CdSeS QD/SiO2 exhibits excellent properties such as good water solubility, low cytotoxicity, and high quantum yield (QY, up to 0.49) as well as the resistance of photobleaching in aqueous solution. Also, the CdSeS QD/SiO2 nanoparticles homogeneously comprise single CdSeS cores and hold a comparatively small size up to about 11 nm in diameter. Particularly, this method leads to a significant increase in QY as compared to the uncoated CdSeS QDs (similar to 109%, of the initial QY), though only thin silica shells formed in the CdSeS QD/SiO2 structure. By coupling with folic acids, the CdSeS QD/SiO2 conjugates were successfully used for tumor cell labeling. Our results demonstrated a robust hydrophobic QDs-based approach for preparing highly photoluminescent, biocompatible QD/SiO2 through creation of a stable hydrophobic interlayer surrounding the QD cores, which could be also suitable for silica coating of other kinds of hydrophobic nanoparticles.

语种英语
WOS记录号WOS:000270594500040
项目编号2007CB935801
资助机构973 Program
引用统计
被引频次:50[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68249
专题北京大学基础医学院_生物物理学系
北京大学基础医学院
作者单位1.Peking Univ, Biomed Ctr X, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Biophys, Single Mol & Nanobiol Lab, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Han, Rongcheng,Yu, Min,Zheng, Qiang,et al. A Facile Synthesis of Small-Sized, Highly Photoluminescent, and Monodisperse CdSeS QD/SiO2 for Live Cell Imaging[J]. LANGMUIR,2009,25(20):12250-12255.
APA Han, Rongcheng,Yu, Min,Zheng, Qiang,Wang, Lijun,Hong, Yuankai,&Sha, Yinlin.(2009).A Facile Synthesis of Small-Sized, Highly Photoluminescent, and Monodisperse CdSeS QD/SiO2 for Live Cell Imaging.LANGMUIR,25(20),12250-12255.
MLA Han, Rongcheng,et al."A Facile Synthesis of Small-Sized, Highly Photoluminescent, and Monodisperse CdSeS QD/SiO2 for Live Cell Imaging".LANGMUIR 25.20(2009):12250-12255.
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