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学科主题: 基础医学
题名:
A Facile Synthesis of Small-Sized, Highly Photoluminescent, and Monodisperse CdSeS QD/SiO2 for Live Cell Imaging
作者: Han, Rongcheng; Yu, Min; Zheng, Qiang; Wang, Lijun; Hong, Yuankai; Sha, Yinlin1
刊名: LANGMUIR
发表日期: 2009-10-20
DOI: 10.1021/la9016596
卷: 25, 期:20, 页:12250-12255
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
研究领域[WOS]: Chemistry ; Materials Science
关键词[WOS]: QUANTUM-DOT-MICELLES ; REVERSE MICROEMULSION METHOD ; WATER-SOLUBLE NANOPARTICLES ; RECEPTOR-TARGETED DELIVERY ; FOLATE-RECEPTOR ; SILICA SPHERES ; SEMICONDUCTOR NANOCRYSTALS ; DRUG-DELIVERY ; PROBES ; SHELL
英文摘要:

In recent years, silica coating has been extensively investigated to fabricate the biocompatible interface of quantum dots (QDs) for biomedical applications. We here describe a facile and efficient method of synthesizing high-quality silica-coated CdSeS QDs (CdSeS QD/SiO2), where an immediate photoluminescence-favorable microenvironment is first created by assembling amphiphilic molecules around the CdSeS core, and a thin silica shell is further introduced to protect this hydrophobic interlayer, The prepared CdSeS QD/SiO2 exhibits excellent properties such as good water solubility, low cytotoxicity, and high quantum yield (QY, up to 0.49) as well as the resistance of photobleaching in aqueous solution. Also, the CdSeS QD/SiO2 nanoparticles homogeneously comprise single CdSeS cores and hold a comparatively small size up to about 11 nm in diameter. Particularly, this method leads to a significant increase in QY as compared to the uncoated CdSeS QDs (similar to 109%, of the initial QY), though only thin silica shells formed in the CdSeS QD/SiO2 structure. By coupling with folic acids, the CdSeS QD/SiO2 conjugates were successfully used for tumor cell labeling. Our results demonstrated a robust hydrophobic QDs-based approach for preparing highly photoluminescent, biocompatible QD/SiO2 through creation of a stable hydrophobic interlayer surrounding the QD cores, which could be also suitable for silica coating of other kinds of hydrophobic nanoparticles.

语种: 英语
所属项目编号: 2007CB935801
项目资助者: 973 Program
WOS记录号: WOS:000270594500040
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68249
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Peking Univ, Biomed Ctr X, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Biophys, Single Mol & Nanobiol Lab, Beijing 100191, Peoples R China

Recommended Citation:
Han, Rongcheng,Yu, Min,Zheng, Qiang,et al. A Facile Synthesis of Small-Sized, Highly Photoluminescent, and Monodisperse CdSeS QD/SiO2 for Live Cell Imaging[J]. LANGMUIR,2009,25(20):12250-12255.
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