IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Estrogen Receptor-beta, Estrogen Receptor-alpha, and Progesterone Resistance in Endometriosis
Bulun, Serdar E.1; Cheng, You-Hong1; Pavone, Mary Ellen1; Xue, Qing2; Attar, Erkut3; Trukhacheva, Elena1; Tokunaga, Hideki4; Utsunomiya, Hiroki4; Yin, Ping1; Luo, Xia1; Lin, Zhihong1; Imir, Gonca5; Thung, Stephen6; Su, Emily J.1; Kim, J. Julie1
关键词ER-beta ER-alpha PR progesterone resistance DNA methylation epigenetic promoter gene regulation transcription
刊名SEMINARS IN REPRODUCTIVE MEDICINE
2010
DOI10.1055/s-0029-1242991
28期:1页:36-43
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
资助者NICHD ; Friends of Prentice ; NICHD ; Friends of Prentice
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]MESSENGER-RIBONUCLEIC-ACID ; BREAST-CANCER CELLS ; ELEMENT HALF-SITE ; ACTIVATOR PROTEIN-1 ; BINDING-SITES ; STROMAL CELLS ; SP1 SITES ; GENE ; EXPRESSION ; PROMOTER
英文摘要

Loss of progesterone signaling in the endometrium may be a causal factor in the development of endometriosis, and progesterone resistance is commonly observed in women with this disease. In endometriotic stromal cells, the levels of progesterone receptor (PR), particularly the PR-B isoform, are significantly decreased, leading to a loss of paracrine signaling. PR deficiency likely underlies the development of progesterone resistance in women with endometriosis who no longer respond to progestin therapy. Here we review the complex epigenetic and transcriptional mechanisms leading to PR deficiency. The initial event may involve deficient methylation of the estrogen receptor (ER)beta promoter resulting in pathologic overexpression of ER beta in endometriotic stromal cells. We speculate that alterations in the relative levels of ER beta and ER alpha in endometrial tissue dictate E2-regulated PR expression, such that a decreased ER alpha-ER beta ratio may result in suppression of PR. In this review, we propose a molecular model that may be responsible for changes in ER beta and ER alpha leading to PR loss and progesterone resistance in endometriosis.

语种英语
所属项目编号HD040093
资助者NICHD ; Friends of Prentice ; NICHD ; Friends of Prentice
WOS记录号WOS:000273921100006
Citation statistics
Cited Times:109[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68250
Collection北京大学第一临床医学院
作者单位1.Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, Sivas, Turkey
2.Northwestern Univ, Feinberg Sch Med, Dept Obstet & Gynecol, Div Reprod Biol Res, Chicago, IL 60611 USA
3.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
4.Istanbul Univ, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Capa Sch Med, Istanbul, Turkey
5.Tohoku Univ, Sch Med, Dept Obstet & Gynecol, Sendai, Miyagi 980, Japan
6.Yale Univ, Sch Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, New Haven, CT 06510 USA
Recommended Citation
GB/T 7714
Bulun, Serdar E.,Cheng, You-Hong,Pavone, Mary Ellen,et al. Estrogen Receptor-beta, Estrogen Receptor-alpha, and Progesterone Resistance in Endometriosis[J]. SEMINARS IN REPRODUCTIVE MEDICINE,2010,28(1):36-43.
APA Bulun, Serdar E..,Cheng, You-Hong.,Pavone, Mary Ellen.,Xue, Qing.,Attar, Erkut.,...&Kim, J. Julie.(2010).Estrogen Receptor-beta, Estrogen Receptor-alpha, and Progesterone Resistance in Endometriosis.SEMINARS IN REPRODUCTIVE MEDICINE,28(1),36-43.
MLA Bulun, Serdar E.,et al."Estrogen Receptor-beta, Estrogen Receptor-alpha, and Progesterone Resistance in Endometriosis".SEMINARS IN REPRODUCTIVE MEDICINE 28.1(2010):36-43.
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