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学科主题: 临床医学
题名:
Estrogen Receptor-beta, Estrogen Receptor-alpha, and Progesterone Resistance in Endometriosis
作者: Bulun, Serdar E.1; Cheng, You-Hong1; Pavone, Mary Ellen1; Xue, Qing2; Attar, Erkut3; Trukhacheva, Elena1; Tokunaga, Hideki4; Utsunomiya, Hiroki4; Yin, Ping1; Luo, Xia1; Lin, Zhihong1; Imir, Gonca5; Thung, Stephen6; Su, Emily J.1; Kim, J. Julie1
关键词: ER-beta ; ER-alpha ; PR ; progesterone resistance ; DNA methylation ; epigenetic ; promoter ; gene regulation ; transcription
刊名: SEMINARS IN REPRODUCTIVE MEDICINE
发表日期: 2010
DOI: 10.1055/s-0029-1242991
卷: 28, 期:1, 页:36-43
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: MESSENGER-RIBONUCLEIC-ACID ; BREAST-CANCER CELLS ; ELEMENT HALF-SITE ; ACTIVATOR PROTEIN-1 ; BINDING-SITES ; STROMAL CELLS ; SP1 SITES ; GENE ; EXPRESSION ; PROMOTER
英文摘要:

Loss of progesterone signaling in the endometrium may be a causal factor in the development of endometriosis, and progesterone resistance is commonly observed in women with this disease. In endometriotic stromal cells, the levels of progesterone receptor (PR), particularly the PR-B isoform, are significantly decreased, leading to a loss of paracrine signaling. PR deficiency likely underlies the development of progesterone resistance in women with endometriosis who no longer respond to progestin therapy. Here we review the complex epigenetic and transcriptional mechanisms leading to PR deficiency. The initial event may involve deficient methylation of the estrogen receptor (ER)beta promoter resulting in pathologic overexpression of ER beta in endometriotic stromal cells. We speculate that alterations in the relative levels of ER beta and ER alpha in endometrial tissue dictate E2-regulated PR expression, such that a decreased ER alpha-ER beta ratio may result in suppression of PR. In this review, we propose a molecular model that may be responsible for changes in ER beta and ER alpha leading to PR loss and progesterone resistance in endometriosis.

语种: 英语
所属项目编号: HD040093
项目资助者: NICHD ; Friends of Prentice
WOS记录号: WOS:000273921100006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68250
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Cumhuriyet Univ, Sch Med, Dept Obstet & Gynecol, Sivas, Turkey
2.Northwestern Univ, Feinberg Sch Med, Dept Obstet & Gynecol, Div Reprod Biol Res, Chicago, IL 60611 USA
3.Peking Univ, Hosp 1, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
4.Istanbul Univ, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Capa Sch Med, Istanbul, Turkey
5.Tohoku Univ, Sch Med, Dept Obstet & Gynecol, Sendai, Miyagi 980, Japan
6.Yale Univ, Sch Med, Dept Obstet & Gynecol, Div Maternal Fetal Med, New Haven, CT 06510 USA

Recommended Citation:
Bulun, Serdar E.,Cheng, You-Hong,Pavone, Mary Ellen,et al. Estrogen Receptor-beta, Estrogen Receptor-alpha, and Progesterone Resistance in Endometriosis[J]. SEMINARS IN REPRODUCTIVE MEDICINE,2010,28(1):36-43.
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