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学科主题: 基础医学
题名:
ALK-positive anaplastic large cell lymphoma with an unusual alveolar growth pattern
作者: Yu, Guohua2; Gao, Zifen1; Huang, Xin1
关键词: ALK ; immunohistochemistry ; alveolar ; differential diagnosis
刊名: INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
发表日期: 2014
卷: 7, 期:12, 页:9086-9089
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Pathology
研究领域[WOS]: Oncology ; Pathology
关键词[WOS]: FUSION
英文摘要:

Anaplastic large cell lymphoma (ALCL) possesses a broad morphological spectrum. Currently, we present a case of ALK-positive ALCL presenting with an alveolar growth pattern in a 22-year-old Chinese female. This patient complained of a progressively enlarged mass in the right axillary region for 6 months. Excisional biopsy revealed a well-developed alveolar structure with nests of dyscohesive tumor cells separated by delicate fibrovascular septae. The large pleomorphic cells have irregular nuclei with prominent nucleoli and fine chromatin and abundant pale cytoplasm. The neoplasm stained positively for CD2, CD3 epsilon, CD30, ALK1, EMA and cytotoxic molecules (TIA1 and Granzyme B). Cytogenetic study via interphase Fluorescence in-Situ Hybridization disclosed the rearrangement involving ALK gene. The patient received 6 cycles of CHOP chemotherapy and achieved complete remission. She is alive in good condition up to the present. Our case is biologically similar to the conventional ALK-positive ALCLs and may just represent an unusual morphological appearance.

语种: 英语
WOS记录号: WOS:000348345900097
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/68252
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Sch Med Sci, Dept Pathol, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Qingdao Univ, Affiliated Yuhuangding Hosp, Dept Pathol, Coll Med, Yantai, Peoples R China

Recommended Citation:
Yu, Guohua,Gao, Zifen,Huang, Xin. ALK-positive anaplastic large cell lymphoma with an unusual alveolar growth pattern[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2014,7(12):9086-9089.
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