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学科主题基础医学
ALK-positive anaplastic large cell lymphoma with an unusual alveolar growth pattern
Yu, Guohua2; Gao, Zifen1; Huang, Xin1
关键词ALK immunohistochemistry alveolar differential diagnosis
刊名INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
2014
7期:12页:9086-9089
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Pathology
研究领域[WOS]Oncology ; Pathology
关键词[WOS]FUSION
英文摘要

Anaplastic large cell lymphoma (ALCL) possesses a broad morphological spectrum. Currently, we present a case of ALK-positive ALCL presenting with an alveolar growth pattern in a 22-year-old Chinese female. This patient complained of a progressively enlarged mass in the right axillary region for 6 months. Excisional biopsy revealed a well-developed alveolar structure with nests of dyscohesive tumor cells separated by delicate fibrovascular septae. The large pleomorphic cells have irregular nuclei with prominent nucleoli and fine chromatin and abundant pale cytoplasm. The neoplasm stained positively for CD2, CD3 epsilon, CD30, ALK1, EMA and cytotoxic molecules (TIA1 and Granzyme B). Cytogenetic study via interphase Fluorescence in-Situ Hybridization disclosed the rearrangement involving ALK gene. The patient received 6 cycles of CHOP chemotherapy and achieved complete remission. She is alive in good condition up to the present. Our case is biologically similar to the conventional ALK-positive ALCLs and may just represent an unusual morphological appearance.

语种英语
WOS记录号WOS:000348345900097
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/68252
专题北京大学基础医学院_病理学系
北京大学基础医学院
北京大学药学院_化学生物学系
作者单位1.Peking Univ, Sch Med Sci, Dept Pathol, Hlth Sci Ctr, Beijing 100191, Peoples R China
2.Qingdao Univ, Affiliated Yuhuangding Hosp, Dept Pathol, Coll Med, Yantai, Peoples R China
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Yu, Guohua,Gao, Zifen,Huang, Xin. ALK-positive anaplastic large cell lymphoma with an unusual alveolar growth pattern[J]. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,2014,7(12):9086-9089.
APA Yu, Guohua,Gao, Zifen,&Huang, Xin.(2014).ALK-positive anaplastic large cell lymphoma with an unusual alveolar growth pattern.INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY,7(12),9086-9089.
MLA Yu, Guohua,et al."ALK-positive anaplastic large cell lymphoma with an unusual alveolar growth pattern".INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY 7.12(2014):9086-9089.
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